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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 4
1947 5
1948 4
1949 1
1950 9
1951 11
1952 19
1953 72
1954 73
1955 43
1956 48
1957 58
1958 41
1959 27
1960 21
1961 23
1962 49
1963 89
1964 93
1965 56
1966 54
1967 64
1968 47
1969 77
1970 71
1971 70
1972 96
1973 112
1974 149
1975 126
1976 128
1977 172
1978 174
1979 203
1980 260
1981 289
1982 254
1983 287
1984 290
1985 311
1986 283
1987 284
1988 308
1989 386
1990 318
1991 352
1992 339
1993 354
1994 309
1995 326
1996 255
1997 278
1998 238
1999 211
2000 221
2001 219
2002 249
2003 315
2004 319
2005 402
2006 434
2007 458
2008 526
2009 518
2010 551
2011 602
2012 604
2013 651
2014 668
2015 585
2016 630
2017 595
2018 633
2019 710
2020 725
2021 733
2022 558
2023 399
2024 177

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Page 1
Showing results for pyridazin
Your search for ridazin retrieved no results
Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors.
Martínez-González S, Rodríguez-Arístegui S, Gómez de la Oliva CA, Hernández AI, González Cantalapiedra E, Varela C, García AB, Rabal O, Oyarzabal J, Bischoff JR, Klett J, Albarrán MI, Cebriá A, Ajenjo N, García-Serelde B, Gómez-Casero E, Cuadrado-Urbano M, Cebrián D, Blanco-Aparicio C, Pastor J. Martínez-González S, et al. Eur J Med Chem. 2019 Apr 15;168:87-109. doi: 10.1016/j.ejmech.2019.02.022. Epub 2019 Feb 19. Eur J Med Chem. 2019. PMID: 30802730
As part of our ongoing exploration for potential drug candidates that exhibit affinity towards this protein family, we have generated a novel chemical series of triazolo[4,3-b]pyridazine based tricycles by applying a scaffold hopping strategy over our previously reported p …
As part of our ongoing exploration for potential drug candidates that exhibit affinity towards this protein family, we have generated a nove …
Structure-based development of PDEδ inhibitors.
Martín-Gago P, Fansa EK, Wittinghofer A, Waldmann H. Martín-Gago P, et al. Biol Chem. 2017 May 1;398(5-6):535-545. doi: 10.1515/hsz-2016-0272. Biol Chem. 2017. PMID: 27935847 Free article. Review.
Structure and cytotoxic properties of 1-hydroxy-5-methyl-7-phenylpyrido[3,4-d]pyridazin-4(3H)-one and its mono- and disubstituted ethyl acetates.
Wójcicka A, Becan L, Rembiałkowska N, Pyra A, Bryndal I. Wójcicka A, et al. Acta Crystallogr C Struct Chem. 2022 Oct 1;78(Pt 10):559-569. doi: 10.1107/S2053229622009202. Epub 2022 Sep 23. Acta Crystallogr C Struct Chem. 2022. PMID: 36196789
Derivatives of pyrido[3,4-d]pyridazine, namely, 1-hydroxy-5-methyl-7-phenylpyrido[3,4-d]pyridazin-4(3H)-one dimethylformamide monosolvate, C(14)H(11)N(3)O(2).C(3)H(7)NO (2), ethyl [1-(2-ethoxy-2-oxoethoxy)-5-methyl-4-oxo-7-phenyl-3,4-dihydropyrido[3,4-d]pyridazin …
Derivatives of pyrido[3,4-d]pyridazine, namely, 1-hydroxy-5-methyl-7-phenylpyrido[3,4-d]pyridazin-4(3H)-one dimethylformamide …
Syntheses and Applications of 1,2,3-Triazole-Fused Pyrazines and Pyridazines.
Hoffman GR, Schoffstall AM. Hoffman GR, et al. Molecules. 2022 Jul 22;27(15):4681. doi: 10.3390/molecules27154681. Molecules. 2022. PMID: 35897857 Free PMC article. Review.
Pyrazines and pyridazines fused to 1,2,3-triazoles comprise a set of heterocycles obtained through a variety of synthetic routes. ...
Pyrazines and pyridazines fused to 1,2,3-triazoles comprise a set of heterocycles obtained through a variety of synthetic routes. ...
Pyridazine-derived gamma-secretase modulators.
Wan Z, Hall A, Jin Y, Xiang JN, Yang E, Eatherton A, Smith B, Yang G, Yu H, Wang J, Ye L, Lau LF, Yang T, Mitchell W, Cai W, Zhang X, Sang Y, Wang Y, Tong Z, Cheng Z, Hussain I, Elliott JD, Matsuoka Y. Wan Z, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4016-9. doi: 10.1016/j.bmcl.2011.04.143. Epub 2011 May 13. Bioorg Med Chem Lett. 2011. PMID: 21636276
SAR of a novel series of pyridazine-derived gamma-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Abeta42 and Abeta40, and maintain the levels of total Abeta. ...
SAR of a novel series of pyridazine-derived gamma-secretase modulators is described. Compound 25 was found to be a potent modulator i …
Cytotoxicity of new pyridazin-3(2H)-one derivatives orchestrating oxidative stress in human triple-negative breast cancer (MDA-MB-468).
Bouchmaa N, Ben Mrid R, Boukharsa Y, Nhiri M, Ait Mouse H, Taoufik J, Ansar M, Zyad A. Bouchmaa N, et al. Arch Pharm (Weinheim). 2018 Dec;351(12):e1800128. doi: 10.1002/ardp.201800128. Epub 2018 Oct 29. Arch Pharm (Weinheim). 2018. PMID: 30370633
The current study investigated the antitumor effect of new pyridazin-3(2H)-one derivatives on the human TNBC cell line, MD-MB-468. ...
The current study investigated the antitumor effect of new pyridazin-3(2H)-one derivatives on the human TNBC cell line, MD-MB-468. .. …
Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors.
Kang ST, Kim EY, Achary R, Jung H, Park CH, Yun CS, Hwang JY, Choi SU, Chae C, Lee CO, Kim HR, Ha JD, Ryu D, Cho SY. Kang ST, et al. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5093-7. doi: 10.1016/j.bmcl.2014.08.067. Epub 2014 Sep 16. Bioorg Med Chem Lett. 2014. PMID: 25282552
We report a series of phenyl substituted pyridazin-3-ones substituted with morpholino-pyrimidines. The SAR of the phenyl was explored and their c-Met kinase and cell-based inhibitory activity toward c-Met driven cell lines were evaluated. ...
We report a series of phenyl substituted pyridazin-3-ones substituted with morpholino-pyrimidines. The SAR of the phenyl was explored …
Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis.
Mammoliti O, Palisse A, Joannesse C, El Bkassiny S, Allart B, Jaunet A, Menet C, Coornaert B, Sonck K, Duys I, Clément-Lacroix P, Oste L, Borgonovi M, Wakselman E, Christophe T, Houvenaghel N, Jans M, Heckmann B, Sanière L, Brys R. Mammoliti O, et al. J Med Chem. 2021 May 13;64(9):6037-6058. doi: 10.1021/acs.jmedchem.1c00138. Epub 2021 May 3. J Med Chem. 2021. PMID: 33939425
A chemical enablement strategy led to the discovery of a pyridine series with good antagonist activity. A pyridazine series with improved lipophilic efficiency and with no CYP inhibition liability was identified by scaffold hopping. ...
A chemical enablement strategy led to the discovery of a pyridine series with good antagonist activity. A pyridazine series with impr …
19,228 results
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