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Showing results for gomisin
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Gomisin N attenuated cerebral ischemia-reperfusion injury through inhibition of autophagy by activating the PI3K/AKT/mTOR pathway.
Li R, Zheng Y, Zhang J, Zhou Y, Fan X. Li R, et al. Phytomedicine. 2023 Feb;110:154644. doi: 10.1016/j.phymed.2023.154644. Epub 2023 Jan 4. Phytomedicine. 2023. PMID: 36634381
Studies have shown that autophagy is essential to maintain cell homeostasis and inevitably lead to neuronal damage after cerebral ischemia. Gomisin N (GN), lignin isolated from Schisandra chinensis, possesses multiple pharmacological activities. ...
Studies have shown that autophagy is essential to maintain cell homeostasis and inevitably lead to neuronal damage after cerebral ischemia. …
Gomisin G improves muscle strength by enhancing mitochondrial biogenesis and function in disuse muscle atrophic mice.
Yeon M, Choi H, Chun KH, Lee JH, Jun HS. Yeon M, et al. Biomed Pharmacother. 2022 Sep;153:113406. doi: 10.1016/j.biopha.2022.113406. Epub 2022 Jul 14. Biomed Pharmacother. 2022. PMID: 36076532 Free article.
Here, we induced disuse muscle atrophy through wire immobilization of the hind legs in mice followed by the oral administration of gomisin G. The cross-sectional area and muscle strength in disuse muscle atrophic mice were increased by gomisin G; however, the total …
Here, we induced disuse muscle atrophy through wire immobilization of the hind legs in mice followed by the oral administration of gomisi …
Gomisin D alleviates liver fibrosis through targeting PDGFRbeta in hepatic stellate cells.
Wang R, Liu F, Chen P, Li S, Gu Y, Wang L, Chen C, Yuan Y. Wang R, et al. Int J Biol Macromol. 2023 Apr 30;235:123639. doi: 10.1016/j.ijbiomac.2023.123639. Epub 2023 Feb 22. Int J Biol Macromol. 2023. PMID: 36822287 Free article.
Previously, by modeling PDGFRbeta affinity chromatography, we found that gomisin D can target PDGFRbeta. However, whether gomisin D has anti-fibrosis effects through targeting PDGFRbeta remained unclear. ...In addition, gomisin D had a good binding ability wi …
Previously, by modeling PDGFRbeta affinity chromatography, we found that gomisin D can target PDGFRbeta. However, whether gomisin …
Multifunctional Gomisin B enhances cognitive function in APP/PS1 transgenic mice by regulating Abeta clearance and neuronal apoptosis.
Liu J, Zuo X, Huang M, Fang J, Li W, Shi Q, Wang Q, Liang Y. Liu J, et al. Biomed Pharmacother. 2023 Oct;166:115423. doi: 10.1016/j.biopha.2023.115423. Epub 2023 Sep 8. Biomed Pharmacother. 2023. PMID: 37673021 Free article.
Moreover, the simultaneous administration of OST and Gomisin B demonstrated enhanced therapeutic effects. These effects were attributed to the inhibition of beta-site APP-Cleaving Enzyme 1 (BACE1) and oxidative stress by Gomisin B, along with its anti-apoptotic prop …
Moreover, the simultaneous administration of OST and Gomisin B demonstrated enhanced therapeutic effects. These effects were attribut …
Action of the natural compound gomisin a on Ca(2+) movement in human prostate cancer cells.
Hao LJ, Lin RA, Chen LC, Wang JL, Chen IS, Kuo CC, Chou CT, Chien JM, Jan CR. Hao LJ, et al. Chin J Physiol. 2022 May-Jun;65(3):151-157. doi: 10.4103/cjp.cjp_6_22. Chin J Physiol. 2022. PMID: 35775534 Free article.
However, the benefit of gomisin A is still not well understood. The action of gomisin A is diverse. ...U73122 fell short to change gomisin A-caused [Ca(2+)](i) responses. Gomisin A (20-100 muM) elicited cytotoxicity in a dose-associated fashion. ...
However, the benefit of gomisin A is still not well understood. The action of gomisin A is diverse. ...U73122 fell short to ch …
Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells.
Kim JS, Jeong SH, Han SH, Yi HK. Kim JS, et al. Clin Exp Pharmacol Physiol. 2018 Jun;45(6):547-555. doi: 10.1111/1440-1681.12914. Epub 2018 Feb 13. Clin Exp Pharmacol Physiol. 2018. PMID: 29319901
However, the potential benefit of gomisin A is still not well understood, especially in aging progression. ...Gomisin A inhibited reactive oxygen species production even in the SIPS-HDF cells. ...
However, the potential benefit of gomisin A is still not well understood, especially in aging progression. ...Gomisin A inhibi …
Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells.
Hosokawa Y, Hosokawa I, Shindo S, Ozaki K, Matsuo T. Hosokawa Y, et al. Inflammation. 2017 Apr;40(2):360-365. doi: 10.1007/s10753-016-0482-4. Inflammation. 2017. PMID: 27896541
Gomisin N, which is a lignan isolated from Schisandra chinensis, has some pharmacological effects. However, the anti-inflammatory effects of gomisin N on periodontal disease are uncertain. The aim of this study was to examine the effect of gomisin N on inflam …
Gomisin N, which is a lignan isolated from Schisandra chinensis, has some pharmacological effects. However, the anti-inflammatory eff …
Gomisin M2 from Baizuan suppresses breast cancer stem cell proliferation in a zebrafish xenograft model.
Yang Y, Hao E, Pan X, Tan D, Du Z, Xie J, Hou X, Deng J, Wei K. Yang Y, et al. Aging (Albany NY). 2019 Oct 14;11(19):8347-8361. doi: 10.18632/aging.102323. Epub 2019 Oct 14. Aging (Albany NY). 2019. PMID: 31612865 Free PMC article.
The ability of Gomisin M2 to kill breast cancer stem cells was evaluated in vitro and in vivo. ...Gomisin M2 suppressed the proliferation of MDA-MB-231 and HCC1806 xenografts in zebrafish. ...
The ability of Gomisin M2 to kill breast cancer stem cells was evaluated in vitro and in vivo. ...Gomisin M2 suppressed the pr …
Gomisin L1, a Lignan Isolated from Schisandra Berries, Induces Apoptosis by Regulating NADPH Oxidase in Human Ovarian Cancer Cells.
Ko YH, Jeong M, Jang DS, Choi JH. Ko YH, et al. Life (Basel). 2021 Aug 21;11(8):858. doi: 10.3390/life11080858. Life (Basel). 2021. PMID: 34440602 Free PMC article.
Gomisin L1 exhibited potent cytotoxic activity against A2780 and SKOV3 ovarian cancer cells. Flow cytometry analysis revealed that the growth inhibitory effects of gomisin L1 were mediated by the induction of apoptosis. Furthermore, gomisin L1 induced an incr …
Gomisin L1 exhibited potent cytotoxic activity against A2780 and SKOV3 ovarian cancer cells. Flow cytometry analysis revealed that th …
Gomisin M2 alleviates psoriasis-like skin inflammation by inhibiting inflammatory signaling pathways.
Kim N, Lee S, Kang J, Kwon TK, Khang D, Kim SH. Kim N, et al. Mol Med Rep. 2021 Dec;24(6):859. doi: 10.3892/mmr.2021.12499. Epub 2021 Oct 19. Mol Med Rep. 2021. PMID: 34664681 Free PMC article.
Hence, supplements and therapeutic agents have been intensely investigated. Gomisin M2 (GM2), a lignan extracted from Schisandra chinensis (Turcz). ...
Hence, supplements and therapeutic agents have been intensely investigated. Gomisin M2 (GM2), a lignan extracted from Schisandra chin …
264 results