A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells.
Scott B, Shen J, Nizzero S, Boom K, Persano S, Mi Y, Liu X, Zhao Y, Blanco E, Shen H, Ferrari M, Wolfram J.
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Pharmacol Res. 2016 Sep;111:413-421. doi: 10.1016/j.phrs.2016.07.005. Epub 2016 Jul 6.
Pharmacol Res. 2016.
PMID: 27394167
Free PMC article.
Cancer cells have high rates of glycolysis and lactic acid fermentation in order to fuel accelerated rates of cell division (Warburg effect). ...To overcome the challenges of protein delivery, a nanoparticle-based system consisting of cationic lipids and porous silicon …
Cancer cells have high rates of glycolysis and lactic acid fermentation in order to fuel accelerated rates of cell division (Warburg …