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Salidroside induces apoptosis and triggers endoplasmic reticulum stress in human hepatocellular carcinoma.
Ding SY, Wang MT, Dai DF, Peng JL, Wu WL. Ding SY, et al. Biochem Biophys Res Commun. 2020 Jul 5;527(4):1057-1063. doi: 10.1016/j.bbrc.2020.05.066. Epub 2020 May 18. Biochem Biophys Res Commun. 2020. PMID: 32439176
Salidroside possesses excellent anti-tumor activity in many types of malignant tumor. In present study, we focused on the effects of salidroside on hepatocellular carcinoma (HCC). The viability of human HCC cells was assayed using MTT. ...
Salidroside possesses excellent anti-tumor activity in many types of malignant tumor. In present study, we focused on the effects of …
Crosstalk between autophagy inhibitor and salidroside-induced apoptosis: A novel strategy for autophagy-based treatment of hepatocellular cancer.
Jiang B, Cui Y, Ma X, Zhang Y, Feng X, Yang T, Feng L, Guo W, Li Y, Wang T, Guo H, Li H, Duan Y, Su H. Jiang B, et al. Int Immunopharmacol. 2023 Nov;124(Pt B):111040. doi: 10.1016/j.intimp.2023.111040. Epub 2023 Oct 13. Int Immunopharmacol. 2023. PMID: 37839277 Free article.
The present study demonstrated that seven autophagy related genes were screened from the biological network of salidroside (Sal) acting on liver cancer. The GO analysis showed that these genes were mainly involved in apoptosis and autophagy. ...
The present study demonstrated that seven autophagy related genes were screened from the biological network of salidroside (Sal) acti …
Salidroside stimulates the accumulation of HIF-1alpha protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cells.
Zheng KY, Zhang ZX, Guo AJ, Bi CW, Zhu KY, Xu SL, Zhan JY, Lau DT, Dong TT, Choi RC, Tsim KW. Zheng KY, et al. Eur J Pharmacol. 2012 Mar 15;679(1-3):34-9. doi: 10.1016/j.ejphar.2012.01.027. Epub 2012 Jan 31. Eur J Pharmacol. 2012. PMID: 22309741
Cultured human embryonic kidney fibroblast (HEK293T) and human hepatocellular carcinoma (HepG2) were used to reveal the mechanism of this hematopoietic function mediated by salidroside. ...The application of salidroside stimulated the accumulation of h …
Cultured human embryonic kidney fibroblast (HEK293T) and human hepatocellular carcinoma (HepG2) were used to reveal the mechan …
Salidroside improves the hypoxic tumor microenvironment and reverses the drug resistance of platinum drugs via HIF-1alpha signaling pathway.
Qin Y, Liu HJ, Li M, Zhai DH, Tang YH, Yang L, Qiao KL, Yang JH, Zhong WL, Zhang Q, Liu YR, Yang G, Sun T, Yang C. Qin Y, et al. EBioMedicine. 2018 Dec;38:25-36. doi: 10.1016/j.ebiom.2018.10.069. Epub 2018 Nov 2. EBioMedicine. 2018. PMID: 30396856 Free PMC article.
The hypoxia in the center of solid tumors considerably decreases the chemosensitivity of tumor cells and induces epithelial-mesenchymal transition (EMT) as well as drug resistance of antitumor drugs. METHODS: Here, the effects of salidroside (Sal) combined with platinum dr …
The hypoxia in the center of solid tumors considerably decreases the chemosensitivity of tumor cells and induces epithelial-mesenchymal tran …
Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy.
Jiang B, Feng L, Yang T, Guo W, Li Y, Wang T, Liu C, Su H. Jiang B, et al. Mol Med Rep. 2023 Feb;27(2):37. doi: 10.3892/mmr.2022.12924. Epub 2022 Dec 29. Mol Med Rep. 2023. PMID: 36579660 Free PMC article.
Hepatocellular carcinoma (HCC) is the leading cause of cancer-associated death in the world. ...Despite advances in chemotherapy and modalities, recurrence and resistance limit therapeutic success. Salidroside (Sal), a bioactive component extracted from the r …
Hepatocellular carcinoma (HCC) is the leading cause of cancer-associated death in the world. ...Despite advances in chemothera …
Salidroside suppresses the metastasis of hepatocellular carcinoma cells by inhibiting the activation of the Notch1 signaling pathway.
Lu L, Liu S, Dong Q, Xin Y. Lu L, et al. Mol Med Rep. 2019 Jun;19(6):4964-4972. doi: 10.3892/mmr.2019.10115. Epub 2019 Apr 2. Mol Med Rep. 2019. PMID: 30942419
Salidroside (SDS) is a phenylpropanoid glycoside isolated from Rhodiola rosea L. ...The present study investigated the inhibitory effects of SDS on tumor invasion and migration, and the expression of metastasis-related genes in highly metastatic hepatocellular ca …
Salidroside (SDS) is a phenylpropanoid glycoside isolated from Rhodiola rosea L. ...The present study investigated the inhibitory eff …
Salix alba (white willow) medicinal plant presents genotoxic effects in human cultured leukocytes.
Maistro EL, Terrazzas PM, Perazzo FF, Gaivão IOM, Sawaya ACHF, Rosa PCP. Maistro EL, et al. J Toxicol Environ Health A. 2019;82(23-24):1223-1234. doi: 10.1080/15287394.2019.1711476. Epub 2020 Jan 6. J Toxicol Environ Health A. 2019. PMID: 31906808
Considering the lack of studies evaluating the genetic toxicity and cytotoxic action of SA bark extract on human cells, as well as the chemical characterization of its major phenolic compounds, the present study was designed to (1) investigate the cytotoxic and genotoxic potentia …
Considering the lack of studies evaluating the genetic toxicity and cytotoxic action of SA bark extract on human cells, as well as the chemi …
Regulatory effect of PINK1/Parkin axis on mitophagy in isoniazide-induced hepatocellular injury.
Xu Y, Li Y. Xu Y, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Sep 28;47(9):1200-1207. doi: 10.11817/j.issn.1672-7347.2022.210407. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022. PMID: 36411703 Free PMC article. Chinese, English.
This study aims to explore the mechanism of PINK1/Parkin signal axis in regulating hepatocellular injury induced by anti-tuberculosis drugs through mitochondrial autophagy, and to provide new therapeutic targets for the patients with liver damage caused by anti-tuberculosi …
This study aims to explore the mechanism of PINK1/Parkin signal axis in regulating hepatocellular injury induced by anti-tuberculosis …
Rhodiola crenulata extract suppresses hepatic gluconeogenesis via activation of the AMPK pathway.
Lee SY, Lai FY, Shi LS, Chou YC, Yen IC, Chang TC. Lee SY, et al. Phytomedicine. 2015 Apr 15;22(4):477-86. doi: 10.1016/j.phymed.2015.01.016. Epub 2015 Mar 11. Phytomedicine. 2015. PMID: 25925970
PURPOSE: The current study was designed to examine the effects of Rhodiola crenulata root extract (RCE) on hepatic glucose production. METHODS: Human hepatoma HepG2 cells were treated with RCE for 6 h. Glucose production, the expression level of p-AMPK, and the expression …
PURPOSE: The current study was designed to examine the effects of Rhodiola crenulata root extract (RCE) on hepatic glucose production. METHO …
Comparative study of relationship between structure of phenylethanoid glycopyranosides and their activities using cell-free assays and human cells cultured in vitro.
Horvathova E, Mastihubova M, Karnisova Potocka E, Kis P, Galova E, Sevcovicova A, Klapakova M, Hunakova L, Mastihuba V. Horvathova E, et al. Toxicol In Vitro. 2019 Dec;61:104646. doi: 10.1016/j.tiv.2019.104646. Epub 2019 Sep 10. Toxicol In Vitro. 2019. PMID: 31518671
The aims of our study were (i) to synthesize phenylethanoid glycopyranosides: salidroside (SALI - tyrosol beta-d-glucopyranoside), tyrosol beta-d-galactopyranoside (TYBGAL), tyrosol alpha-d-galactopyranoside (TYAGAL), tyrosol alpha-d-mannopyranoside (TYAMAN), hydroxytyroso …
The aims of our study were (i) to synthesize phenylethanoid glycopyranosides: salidroside (SALI - tyrosol beta-d-glucopyranoside), ty …
11 results