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Showing results for saposin
Your search for sanosin retrieved no results
The role of saposin C in Gaucher disease.
Tamargo RJ, Velayati A, Goldin E, Sidransky E. Tamargo RJ, et al. Mol Genet Metab. 2012 Jul;106(3):257-63. doi: 10.1016/j.ymgme.2012.04.024. Epub 2012 May 5. Mol Genet Metab. 2012. PMID: 22652185 Free PMC article. Review.
Saposin C is one of four homologous proteins derived from sequential cleavage of the saposin precursor protein, prosaposin. ...Saposin C deficiency has also been shown to modify phenotype in one mouse model of Gaucher disease. ...
Saposin C is one of four homologous proteins derived from sequential cleavage of the saposin precursor protein, prosaposin. .. …
Preface.
Ziegler C. Ziegler C. Methods Enzymol. 2017;594:xi-xii. doi: 10.1016/S0076-6879(17)30277-X. Methods Enzymol. 2017. PMID: 28779845 No abstract available.
Saposin proteins: structure, function, and role in human lysosomal storage disorders.
O'Brien JS, Kishimoto Y. O'Brien JS, et al. FASEB J. 1991 Mar 1;5(3):301-8. doi: 10.1096/fasebj.5.3.2001789. FASEB J. 1991. PMID: 2001789 Review.
Saposins are sphingolipid activator proteins, four of which are derived from a single precursor, prosaposin, by proteolytic processing. ...
Saposins are sphingolipid activator proteins, four of which are derived from a single precursor, prosaposin, by proteolytic processin …
Prosaposin mediates inflammation in atherosclerosis.
van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Pérez-Medina C, Kluza E, Ye YX, Wojtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R. van Leent MMT, et al. Sci Transl Med. 2021 Mar 10;13(584):eabe1433. doi: 10.1126/scitranslmed.abe1433. Sci Transl Med. 2021. PMID: 33692130 Free PMC article.
Hyperglycosylation of prosaposin in tumor dendritic cells drives immune escape.
Sharma P, Zhang X, Ly K, Kim JH, Wan Q, Kim J, Lou M, Kain L, Teyton L, Winau F. Sharma P, et al. Science. 2024 Jan 12;383(6679):190-200. doi: 10.1126/science.adg1955. Epub 2024 Jan 11. Science. 2024. PMID: 38207022
In this work, we show that prosaposin (pSAP) drives CD8 T cell-mediated tumor immunity and that its hyperglycosylation in tumor dendritic cells (DCs) leads to cancer immune escape. We found that lysosomal pSAP and its single-saposin cognates mediated disintegration of tumo …
In this work, we show that prosaposin (pSAP) drives CD8 T cell-mediated tumor immunity and that its hyperglycosylation in tumor dendritic ce …
Saposin-like proteins in Opisthorchis felineus and related opisthorchids.
Pirozhkova D, Katokhin A. Pirozhkova D, et al. Infect Genet Evol. 2020 Mar;78:104132. doi: 10.1016/j.meegid.2019.104132. Epub 2019 Dec 2. Infect Genet Evol. 2020. PMID: 31805380
Saposin B domain-containing or saposin-like proteins (SAPs, SAPLIPs) have been described as lipid/membrane-binding and often show antibacterial and cytolytic activity. ...
Saposin B domain-containing or saposin-like proteins (SAPs, SAPLIPs) have been described as lipid/membrane-binding and often s …
Saposin C, Key Regulator in the Alpha-Synuclein Degradation Mediated by Lysosome.
Ruz C, Barrero FJ, Pelegrina J, Bandrés-Ciga S, Vives F, Duran R. Ruz C, et al. Int J Mol Sci. 2022 Oct 9;23(19):12004. doi: 10.3390/ijms231912004. Int J Mol Sci. 2022. PMID: 36233303 Free PMC article.
PSAP and Saposin C protein levels were significantly lower in PD patients and correlated with increased levels of alpha-synuclein. ...Our findings suggest that lysosomal dysfunction in sporadic PD is due, at least in part, to an alteration in Saposin C derived from …
PSAP and Saposin C protein levels were significantly lower in PD patients and correlated with increased levels of alpha-synuclein. .. …
Stable Picodisc Assemblies from Saposin Proteins and Branched Detergents.
Kurgan KW, Chen B, Brown KA, Falco Cobra P, Ye X, Ge Y, Gellman SH. Kurgan KW, et al. Biochemistry. 2021 Apr 13;60(14):1108-1119. doi: 10.1021/acs.biochem.0c00924. Epub 2021 Mar 23. Biochemistry. 2021. PMID: 33755420 Free PMC article.
In search of new picodisc assemblies, we have explored pairings of saposin A or other saposin proteins with a range of detergents, and we have identified a number of combinations that spontaneously co-assemble at neutral pH. ...The new assemblies are formed by doubl …
In search of new picodisc assemblies, we have explored pairings of saposin A or other saposin proteins with a range of deterge …
1,001 results