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1997 1
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Page 1
Showing results for evotec
Your search for sefpotec retrieved no results
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, Pilka ES, Aspris D, Leggate D, Hendrick AG, Webster NA, Andrews B, Fosbeary R, Guest P, Irigoyen N, Eleftheriou M, Gozdecka M, Dias JML, Bannister AJ, Vick B, Jeremias I, Vassiliou GS, Rausch O, Tzelepis K, Kouzarides T. Yankova E, et al. Nature. 2021 May;593(7860):597-601. doi: 10.1038/s41586-021-03536-w. Epub 2021 Apr 26. Nature. 2021. PMID: 33902106 Free PMC article.
Increased cell senescence in human metabolic disorders.
Spinelli R, Baboota RK, Gogg S, Beguinot F, Blüher M, Nerstedt A, Smith U. Spinelli R, et al. J Clin Invest. 2023 Jun 15;133(12):e169922. doi: 10.1172/JCI169922. J Clin Invest. 2023. PMID: 37317964 Free PMC article. Review.
Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Zhang J, Lair C, Roubert C, Amaning K, Barrio MB, Benedetti Y, Cui Z, Xing Z, Li X, Franzblau SG, Baurin N, Bordon-Pallier F, Cantalloube C, Sans S, Silve S, Blanc I, Fraisse L, Rak A, Jenner LB, Yusupova G, Yusupov M, Zhang J, Kaneko T, Yang TJ, Fotouhi N, Nuermberger E, Tyagi S, Betoudji F, Upton A, Sacchettini JC, Lagrange S. Zhang J, et al. Cell. 2023 Mar 2;186(5):1013-1025.e24. doi: 10.1016/j.cell.2023.01.043. Epub 2023 Feb 23. Cell. 2023. PMID: 36827973 Free PMC article.
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T. Shi Y, et al. Mol Cell. 2022 May 5;82(9):1643-1659.e10. doi: 10.1016/j.molcel.2022.03.007. Epub 2022 Mar 24. Mol Cell. 2022. PMID: 35334231 Free PMC article.
Dimdazenil: First Approval.
Syed YY. Syed YY. Drugs. 2024 Mar 28. doi: 10.1007/s40265-024-02020-9. Online ahead of print. Drugs. 2024. PMID: 38546956 Review.
Dimdazenil (Junoenil()) is a small-molecule, oral, partial positive allosteric modulator of the gamma-aminobutyric acid (GABA)(A) receptor that is being developed by Zhejiang Jingxin Pharmaceutical in collaboration with Evotec for the treatment of insomnia. Dimdazenil is d …
Dimdazenil (Junoenil()) is a small-molecule, oral, partial positive allosteric modulator of the gamma-aminobutyric acid (GABA)(A) receptor t …
Machine Learning from Omics Data.
Rex R. Rex R. Methods Mol Biol. 2022;2390:421-431. doi: 10.1007/978-1-0716-1787-8_18. Methods Mol Biol. 2022. PMID: 34731480
The code to reproduce the results is available at https://github.com/Evotec-Bioinformatics/ml-from-omics ....
The code to reproduce the results is available at https://github.com/Evotec-Bioinformatics/ml-from-omics ....
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration.
Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T. Figley MD, et al. Neuron. 2021 Apr 7;109(7):1118-1136.e11. doi: 10.1016/j.neuron.2021.02.009. Epub 2021 Mar 2. Neuron. 2021. PMID: 33657413 Free PMC article.
904 results