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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1930 1
1942 1
1947 2
1951 1
1955 1
1957 1
1959 1
1960 2
1964 4
1965 1
1966 7
1967 5
1968 8
1969 14
1970 14
1971 12
1972 27
1973 16
1974 33
1975 120
1976 124
1977 126
1978 137
1979 160
1980 165
1981 204
1982 231
1983 302
1984 373
1985 443
1986 503
1987 614
1988 764
1989 985
1990 1231
1991 1532
1992 1879
1993 2221
1994 2636
1995 2919
1996 2982
1997 2646
1998 2930
1999 3103
2000 3498
2001 3868
2002 3968
2003 4497
2004 5124
2005 5706
2006 6153
2007 6314
2008 6534
2009 7357
2010 8076
2011 8580
2012 9108
2013 9566
2014 9985
2015 10174
2016 9970
2017 10062
2018 10493
2019 11263
2020 12292
2021 13435
2022 13528
2023 13230
2024 6501

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216,981 results

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Page 1
Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution.
Liu Y, Siejka-Zielińska P, Velikova G, Bi Y, Yuan F, Tomkova M, Bai C, Chen L, Schuster-Böckler B, Song CX. Liu Y, et al. Nat Biotechnol. 2019 Apr;37(4):424-429. doi: 10.1038/s41587-019-0041-2. Epub 2019 Feb 25. Nat Biotechnol. 2019. PMID: 30804537
However, this harsh chemical treatment degrades the majority of the DNA and generates sequencing libraries with low complexity(2,5,6). Here, we present a bisulfite-free and base-level-resolution sequencing method, TET-assisted pyridine borane sequencing …
However, this harsh chemical treatment degrades the majority of the DNA and generates sequencing libraries with low complexity(2,5,6) …
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype.
Kim D, Paggi JM, Park C, Bennett C, Salzberg SL. Kim D, et al. Nat Biotechnol. 2019 Aug;37(8):907-915. doi: 10.1038/s41587-019-0201-4. Epub 2019 Aug 2. Nat Biotechnol. 2019. PMID: 31375807 Free PMC article.
We present a method named HISAT2 (hierarchical indexing for spliced alignment of transcripts 2) that can align both DNA and RNA sequences using a graph Ferragina Manzini index. We use HISAT2 to represent and search an expanded model of the human reference genome in which o …
We present a method named HISAT2 (hierarchical indexing for spliced alignment of transcripts 2) that can align both DNA and RNA sequences …
Numerical Characterization of DNA Sequences for Alignment-free Sequence Comparison - A Review.
Ramanathan N, Ramamurthy J, Natarajan G. Ramanathan N, et al. Comb Chem High Throughput Screen. 2022;25(3):365-380. doi: 10.2174/1386207324666210811101437. Comb Chem High Throughput Screen. 2022. PMID: 34382516 Review.
This is usually carried out by Multiple Sequence Algorithms (MSA). Due to certain limitations of MSA, alignment-free sequence comparison methods were developed. The present review is on alignment-free sequence comparison methods carried out using the numerica …
This is usually carried out by Multiple Sequence Algorithms (MSA). Due to certain limitations of MSA, alignment-free sequence …
A specific combination of dual index adaptors decreases the sensitivity of amplicon sequencing with the Illumina platform.
Hirose Y, Shiozaki T, Hamano I, Yoshihara S, Tokumoto H, Eki T, Harada N. Hirose Y, et al. DNA Res. 2020 Aug 1;27(4):dsaa017. doi: 10.1093/dnares/dsaa017. DNA Res. 2020. PMID: 32810209 Free PMC article.
This approach determines the composition of sequence variants of marker genes using high-throughput DNA sequencers. ...Each end of the DNA library with this index combination contains a complementary sequence motif, which potentially inhibits proper cl …
This approach determines the composition of sequence variants of marker genes using high-throughput DNA sequencers. ...Each en …
Sequence confirmation of synthetic phosphorothioate oligodeoxynucleotides using Sanger sequencing reactions in combination with mass spectrometry.
Lu DD, Chen SH, Zhang W, Liang QD, Wang SQ. Lu DD, et al. Anal Biochem. 2005 Oct 1;345(1):81-9. doi: 10.1016/j.ab.2005.06.045. Anal Biochem. 2005. PMID: 16102718
A protocol relying on Sanger sequencing reactions in combination with mass spectrometry (MS) for sequence confirmation of antisense phosphorothioate oligodeoxynucleotides is described. ...The method requires only common reagents and instruments and so is bett …
A protocol relying on Sanger sequencing reactions in combination with mass spectrometry (MS) for sequence confirmation …
Methodological aspects of whole-genome bisulfite sequencing analysis.
Adusumalli S, Mohd Omar MF, Soong R, Benoukraf T. Adusumalli S, et al. Brief Bioinform. 2015 May;16(3):369-79. doi: 10.1093/bib/bbu016. Epub 2014 May 27. Brief Bioinform. 2015. PMID: 24867940 Review.
The combination of DNA bisulfite treatment with high-throughput sequencing technologies has enabled investigation of genome-wide DNA methylation beyond CpG sites and CpG islands. ...However, the processing, managing and mining of this huge volume of data require spe …
The combination of DNA bisulfite treatment with high-throughput sequencing technologies has enabled investigation of genome-wi …
Complete nucleotide sequence characterization of DRB5 alleles reveals a homogeneous allele group that is distinct from other DRB genes.
Barsakis K, Babrzadeh F, Chi A, Mallempati K, Pickle W, Mindrinos M, Fernández-Viña MA. Barsakis K, et al. Hum Immunol. 2019 Jul;80(7):437-448. doi: 10.1016/j.humimm.2019.04.001. Epub 2019 Apr 5. Hum Immunol. 2019. PMID: 30954494 Free PMC article.
A better and comprehensive sequence assessment can be achieved by the inclusion of full gene sequences of all the common alleles at a given locus. ...Methodological approaches including robust and efficient long-range PCR amplification, molecular cloning, nucleotide …
A better and comprehensive sequence assessment can be achieved by the inclusion of full gene sequences of all the common allel …
Sequence-directed mapping of nucleosome positions.
Salih F, Salih B, Trifonov EN. Salih F, et al. J Biomol Struct Dyn. 2007 Apr;24(5):489-93. doi: 10.1080/07391102.2007.10507137. J Biomol Struct Dyn. 2007. PMID: 17313194
A nucleosome DNA sequence probe is designed that combines recently derived RR/YY counter-phase and AA/TT in-phase periodical patterns. A simple nucleosome mapping procedure is introduced for prediction of the nucleosome positions in the sequence of interest, …
A nucleosome DNA sequence probe is designed that combines recently derived RR/YY counter-phase and AA/TT in-phase periodical p …
Massively Parallel Analysis of Regulatory RNA Sequences.
Rabani M. Rabani M. Methods Mol Biol. 2021;2218:355-365. doi: 10.1007/978-1-0716-0970-5_28. Methods Mol Biol. 2021. PMID: 33606245
Recently introduced massively parallel tools for the analysis of regulatory RNA sequences provide the ability to detect functional cis-regulatory sequences of post-transcriptional RNA regulation at a much larger scale and resolution than before. ...It surveys …
Recently introduced massively parallel tools for the analysis of regulatory RNA sequences provide the ability to detect functi …
Evolution Analysis of Simple Sequence Repeats in Plant Genome.
Qin Z, Wang Y, Wang Q, Li A, Hou F, Zhang L. Qin Z, et al. PLoS One. 2015 Dec 2;10(12):e0144108. doi: 10.1371/journal.pone.0144108. eCollection 2015. PLoS One. 2015. PMID: 26630570 Free PMC article.
Simple sequence repeats (SSRs) are widespread units on genome sequences, and play many important roles in plants. In order to reveal the evolution of plant genomes, we investigated the evolutionary regularities of SSRs during the evolution of plant species and the p …
Simple sequence repeats (SSRs) are widespread units on genome sequences, and play many important roles in plants. In order to …
216,981 results
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