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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1974 5
1975 6
1976 4
1977 7
1978 4
1979 8
1980 4
1981 4
1982 4
1983 6
1984 5
1985 5
1986 8
1987 5
1988 5
1989 8
1990 12
1991 11
1992 14
1993 9
1994 11
1995 8
1996 9
1997 14
1998 12
1999 12
2000 16
2001 21
2002 26
2003 34
2004 28
2005 39
2006 52
2007 69
2008 60
2009 77
2010 88
2011 88
2012 105
2013 127
2014 122
2015 134
2016 118
2017 148
2018 150
2019 118
2020 143
2021 134
2022 159
2023 142
2024 61

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2,178 results

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Page 1
Role of silibinin in the management of diabetes mellitus and its complications.
Chu C, Li D, Zhang S, Ikejima T, Jia Y, Wang D, Xu F. Chu C, et al. Arch Pharm Res. 2018 Aug;41(8):785-796. doi: 10.1007/s12272-018-1047-x. Epub 2018 Jul 6. Arch Pharm Res. 2018. PMID: 29978427 Review.
Researches also indicated the effectiveness of silibinin in controlling several diabetic complications including neuropathy, retinopathy, impaired healing, hepatopathy, cardiomyopathy, nephropathy, and osteoporosis. In this review, we summarize the recent anti-diabetes fin …
Researches also indicated the effectiveness of silibinin in controlling several diabetic complications including neuropathy, retinopa …
Nanotherapeutic silibinin: An insight of phytomedicine in healthcare reformation.
Takke A, Shende P. Takke A, et al. Nanomedicine. 2019 Oct;21:102057. doi: 10.1016/j.nano.2019.102057. Epub 2019 Jul 21. Nanomedicine. 2019. PMID: 31340181 Review.
Silymarin is extracted from the seeds and fruits of milk thistle plant Silybum marianum which consists of main biologically active component as silibinin. However, the clinical applications of silibinin show some limitations due to low aqueous solubility, poor penet …
Silymarin is extracted from the seeds and fruits of milk thistle plant Silybum marianum which consists of main biologically active component …
Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model.
Liu P, Chen W, Kang Y, Wang C, Wang X, Liu W, Hayashi T, Qiu Z, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Liu P, et al. Arch Biochem Biophys. 2023 Aug;744:109691. doi: 10.1016/j.abb.2023.109691. Epub 2023 Jul 18. Arch Biochem Biophys. 2023. PMID: 37473980
Results show that silibinin not only promotes survival of STZ-treated HT22 cells, but also ameliorates the cognitive impairment and anxiety/depression-like behavior of ICV-STZ rats. ...These results imply that silibinin exerts neuroprotective effect on an STZ-induce …
Results show that silibinin not only promotes survival of STZ-treated HT22 cells, but also ameliorates the cognitive impairment and a …
Nano-soldiers Ameliorate Silibinin Delivery: A Review Study.
Ashrafizadeh M, Ahmadi Z, Mohammadinejad R, Farkhondeh T, Samarghandian S. Ashrafizadeh M, et al. Curr Drug Deliv. 2020;17(1):15-22. doi: 10.2174/1567201816666191112113031. Curr Drug Deliv. 2020. PMID: 31721702 Review.
Hence, there have been attempts to improve the bioavailability of silibinin and it has been suggested that nano-soldiers are potential candidates for this aim. In the present review, we describe the different drug delivery systems for improving the bioavailability of si …
Hence, there have been attempts to improve the bioavailability of silibinin and it has been suggested that nano-soldiers are potentia …
Silibinin alleviates ferroptosis of rat islet beta cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy.
Du Q, Wu X, Ma K, Liu W, Liu P, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T. Du Q, et al. Arch Biochem Biophys. 2023 Jul 15;743:109644. doi: 10.1016/j.abb.2023.109644. Epub 2023 May 26. Arch Biochem Biophys. 2023. PMID: 37245586
This in vitro study investigates the effects of silibinin on palmitic acid (PA) and high glucose (HG)-induced cell loss and ferroptosis of rat insulinoma INS-1 cells. ...By using the pharmacological stimulator and inhibitor of mitophagy, and si-RNA transfection to silence …
This in vitro study investigates the effects of silibinin on palmitic acid (PA) and high glucose (HG)-induced cell loss and ferroptos …
Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulator.
Jahanafrooz Z, Motamed N, Rinner B, Mokhtarzadeh A, Baradaran B. Jahanafrooz Z, et al. Life Sci. 2018 Nov 15;213:236-247. doi: 10.1016/j.lfs.2018.10.009. Epub 2018 Oct 9. Life Sci. 2018. PMID: 30308184 Review.
Silibinin also regulates aberrant miRNAs expression linked to many aspects of cell biology in cancer. ...In this review, we introduce the salient features of silibinin therapy to optimize clinical outcomes for oncology patients. ...
Silibinin also regulates aberrant miRNAs expression linked to many aspects of cell biology in cancer. ...In this review, we introduce …
Study on the Interaction between Silibinin and Neuraminidase.
Fang H, Ding Y, Lu Y, Niu B, Lu H, Chen Q. Fang H, et al. Curr Pharm Des. 2023;29(16):1266-1273. doi: 10.2174/1381612829666230515165041. Curr Pharm Des. 2023. PMID: 37190805
BACKGROUND: Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the potential to inhibit neuraminidase activity. OBJECTIVE: This study aims to explore the interaction between silibinin and neuraminidase …
BACKGROUND: Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the po …
Silibinin: a toxicologist's herbal medicine?
Horowitz BZ. Horowitz BZ. Clin Toxicol (Phila). 2022 Nov;60(11):1194-1197. doi: 10.1080/15563650.2022.2128815. Epub 2022 Oct 12. Clin Toxicol (Phila). 2022. PMID: 36222816
To date toxicologists have relied on animal studies, human case series, or retrospective reviews to decide on its use. In the U.S. the ability to use IV silibinin, its pharmacologically active purified flavonolignan, is hindered by its lack of availability as a Food and Dr …
To date toxicologists have relied on animal studies, human case series, or retrospective reviews to decide on its use. In the U.S. the abili …
Cosmeceuticals and silibinin.
Singh RP, Agarwal R. Singh RP, et al. Clin Dermatol. 2009 Sep-Oct;27(5):479-84. doi: 10.1016/j.clindermatol.2009.05.012. Clin Dermatol. 2009. PMID: 19695480 Free PMC article. Review.
Silibinin is a flavonolignan compound from Silybum marianum (milk thistle plant) that possesses strong antioxidant activity and also modulates many molecular changes caused by xenobiotics and ultraviolet radiation to protect the skin. This contribution reviews the evidence …
Silibinin is a flavonolignan compound from Silybum marianum (milk thistle plant) that possesses strong antioxidant activity and also …
Silibinin Prevents TGFbeta-Induced EMT of RPE in Proliferative Vitreoretinopathy by Inhibiting Stat3 and Smad3 Phosphorylation.
Ma X, Xie Y, Gong Y, Hu C, Qiu K, Yang Y, Shen H, Zhou X, Long C, Lin X. Ma X, et al. Invest Ophthalmol Vis Sci. 2023 Oct 3;64(13):47. doi: 10.1167/iovs.64.13.47. Invest Ophthalmol Vis Sci. 2023. PMID: 37906058 Free PMC article.
An intravitreally injected RPE-induced rat PVR model was used to assess the effect of silibinin on PVR in vivo. RNA-seq was applied to study the molecular mechanism of silibinin-mediated PVR prevention. ...These findings suggest that silibinin may serve as a …
An intravitreally injected RPE-induced rat PVR model was used to assess the effect of silibinin on PVR in vivo. RNA-seq was applied t …
2,178 results

Searches related to "silibinin"