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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 3
1991 3
1992 3
1993 1
1994 7
1995 5
1996 8
1997 5
1998 5
1999 3
2000 7
2001 14
2002 8
2003 17
2004 20
2005 17
2006 29
2007 24
2008 54
2009 38
2010 59
2011 69
2012 50
2013 65
2014 77
2015 65
2016 82
2017 75
2018 87
2019 78
2020 89
2021 79
2022 86
2023 100
2024 37

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1,230 results

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Page 1
Simvastatin induced ferroptosis for triple-negative breast cancer therapy.
Yao X, Xie R, Cao Y, Tang J, Men Y, Peng H, Yang W. Yao X, et al. J Nanobiotechnology. 2021 Oct 9;19(1):311. doi: 10.1186/s12951-021-01058-1. J Nanobiotechnology. 2021. PMID: 34627266 Free PMC article.
Triple-negative breast cancer (TNBC), a management of aggressive breast cancer, remains an unmet medical challenge. ...Given that Fe(3)O(4) have proven for clinical applications by the U.S. Food and Drug Administration (FDA) and SIM could induce cancer cell f …
Triple-negative breast cancer (TNBC), a management of aggressive breast cancer, remains an unmet medical challenge. ...Given t …
The potential use of simvastatin for cancer treatment: A review.
Duarte JA, de Barros ALB, Leite EA. Duarte JA, et al. Biomed Pharmacother. 2021 Sep;141:111858. doi: 10.1016/j.biopha.2021.111858. Epub 2021 Jul 10. Biomed Pharmacother. 2021. PMID: 34323700 Free article. Review.
Statins, typically used to reduce lipid levels, have been rediscovered for exhibiting anticancer activities. Among them, especially simvastatin may influence the proliferation, migration, and survival of cancer cells. ...In this review, we present an overview of the …
Statins, typically used to reduce lipid levels, have been rediscovered for exhibiting anticancer activities. Among them, especially simva …
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer.
Xie W, Peng M, Liu Y, Zhang B, Yi L, Long Y. Xie W, et al. Cell Commun Signal. 2023 Nov 16;21(1):329. doi: 10.1186/s12964-023-01359-y. Cell Commun Signal. 2023. PMID: 37974278 Free PMC article.
BACKGROUND: The outcome of patients with colon cancer is still unsatisfied nowadays. Simvastatin is a type of statins with anti-cancer activity, but its effect on colon cancer cells remains unclear. The present study is intended to determine the underl …
BACKGROUND: The outcome of patients with colon cancer is still unsatisfied nowadays. Simvastatin is a type of statins with ant …
Simvastatin Induces Autophagy and Inhibits Proliferation in Prostate Cancer Cells.
Miyazawa Y, Sekine Y, Oka D, Nakazawa S, Tsuji Y, Nakayama H, Suzuki K. Miyazawa Y, et al. Anticancer Res. 2023 Dec;43(12):5377-5386. doi: 10.21873/anticanres.16741. Anticancer Res. 2023. PMID: 38030198
We conducted research on statin as a novel treatment for castration-resistant prostate cancer (CRPC). This study focused on autophagy in prostate cancer cells and assessed the effects of simvastatin. ...CONCLUSION: Simvastatin induced autophagy and inh …
We conducted research on statin as a novel treatment for castration-resistant prostate cancer (CRPC). This study focused on autophagy …
Cytotoxicity of Simvastatin in Human Breast Cancer MCF-7 and MDA-MB-231 Cell Lines.
Rezano A, Ridhayanti F, Rangkuti AR, Gunawan T, Winarno GNA, Wijaya I. Rezano A, et al. Asian Pac J Cancer Prev. 2021 Feb 1;22(S1):33-42. doi: 10.31557/APJCP.2021.22.S1.33. Asian Pac J Cancer Prev. 2021. PMID: 33576210 Free article.
METHODS: The cytotoxic effect of simvastatin against breast cancer cells were evaluated using MTT assay. ...Consistently, we observed antiproliferative effect of Simvastatin was associated with apoptosis on breast cancer cell lines by determination of …
METHODS: The cytotoxic effect of simvastatin against breast cancer cells were evaluated using MTT assay. ...Consistently, we o …
Simvastatin induces breast cancer cell death through oxidative stress up-regulating miR-140-5p.
Bai F, Yu Z, Gao X, Gong J, Fan L, Liu F. Bai F, et al. Aging (Albany NY). 2019 May 28;11(10):3198-3219. doi: 10.18632/aging.101974. Aging (Albany NY). 2019. PMID: 31138773 Free PMC article.
The purpose of this study was to elucidate the effects of statins on proliferation and apoptosis in the ER-negative breast cancer cell line MDA-MB-231. Our results showed that simvastatin increased the expression of miR-140-5p in a dose dependent manner via activati …
The purpose of this study was to elucidate the effects of statins on proliferation and apoptosis in the ER-negative breast cancer cel …
[Simvastatin, an additional drug against breast cancer?].
Li H, Buquet C, Vannier JP, Abdoul-Azize S. Li H, et al. Med Sci (Paris). 2022 Aug-Sep;38(8-9):646-647. doi: 10.1051/medsci/2022095. Epub 2022 Sep 12. Med Sci (Paris). 2022. PMID: 36094232 Free article. French. No abstract available.
Repositioning of simvastatin for diabetic colon cancer: role of CDK4 inhibition and apoptosis.
Gajjar S, Bora V, Patel BM. Gajjar S, et al. Mol Cell Biochem. 2023 Oct;478(10):2337-2349. doi: 10.1007/s11010-023-04663-w. Epub 2023 Jan 27. Mol Cell Biochem. 2023. PMID: 36703094
There is increased risk of colon cancer in both men and women having diabetes. The objective of the study was to evaluate the role of simvastatin in colon cancer associated with type 2 diabetes mellitus. ...Simvastatin controlled diabetes and colon …
There is increased risk of colon cancer in both men and women having diabetes. The objective of the study was to evaluate the role of …
Predictive pharmacogenetic biomarkers for breast cancer recurrence prevention by simvastatin.
Ahern TP, Damkier P, Feddersen S, Kjærsgaard A, Lash TL, Hamilton-Dutoit S, Lythjohan CB, Ejlertsen B, Christiansen PM, Cronin-Fenton DP. Ahern TP, et al. Acta Oncol. 2020 Sep;59(9):1009-1015. doi: 10.1080/0284186X.2020.1759820. Epub 2020 Apr 30. Acta Oncol. 2020. PMID: 32351149 Free PMC article.
Evidence suggests that they also have anti-neoplastic activity. Several studies show a reduced rate of breast cancer recurrence among lipophilic statin users (e.g., simvastatin), motivating calls for clinical trials of statins in breast cancer patients. ...Ca …
Evidence suggests that they also have anti-neoplastic activity. Several studies show a reduced rate of breast cancer recurrence among …
Simvastatin enhances chemotherapy in cervical cancer via inhibition of multiple prenylation-dependent GTPases-regulated pathways.
Pan Q, Xu J, Ma L. Pan Q, et al. Fundam Clin Pharmacol. 2020 Feb;34(1):32-40. doi: 10.1111/fcp.12479. Epub 2019 May 24. Fundam Clin Pharmacol. 2020. PMID: 31058344
In this study, we show that simvastatin selectively inhibits proliferation and induces apoptosis in cervical cancer cells while sparing normal cervical epithelial cells. ...This might explain the selective inhibitory effects of simvastatin in cervical canc …
In this study, we show that simvastatin selectively inhibits proliferation and induces apoptosis in cervical cancer cells whil …
1,230 results