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Year Number of Results
1995 1
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1998 2
1999 7
2000 6
2001 15
2002 15
2003 16
2004 25
2005 66
2006 92
2007 129
2008 222
2009 304
2010 407
2011 514
2012 626
2013 795
2014 862
2015 1011
2016 994
2017 1109
2018 1265
2019 1353
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2024 747

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15,081 results

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Page 1
Regulation of SIRT1 and Its Roles in Inflammation.
Yang Y, Liu Y, Wang Y, Chao Y, Zhang J, Jia Y, Tie J, Hu D. Yang Y, et al. Front Immunol. 2022 Mar 11;13:831168. doi: 10.3389/fimmu.2022.831168. eCollection 2022. Front Immunol. 2022. PMID: 35359990 Free PMC article. Review.
The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD(+)-dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that plays a role in modulating inflammation. ...We also summarize factors that infl …
The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD(+)-dependent deacetylase belonging t …
SIRT1 and aging related signaling pathways.
Chen C, Zhou M, Ge Y, Wang X. Chen C, et al. Mech Ageing Dev. 2020 Apr;187:111215. doi: 10.1016/j.mad.2020.111215. Epub 2020 Feb 19. Mech Ageing Dev. 2020. PMID: 32084459 Review.
The expression of SIRT1 is diminished with aging in mice. By contrast, increased expression of SIRT1 is sufficient to extend lifespan in yeast, caenorhabditis elegans and mice. ...Meanwhile, the potential therapeutic strategies of targeting SIRT1 to anti-agin …
The expression of SIRT1 is diminished with aging in mice. By contrast, increased expression of SIRT1 is sufficient to extend l …
Sirt1 and the Mitochondria.
Tang BL. Tang BL. Mol Cells. 2016 Feb;39(2):87-95. doi: 10.14348/molcells.2016.2318. Epub 2016 Feb 2. Mol Cells. 2016. PMID: 26831453 Free PMC article. Review.
Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1alpha (PGC-1alpha) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially underli …
Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1a …
SIRT1: A Potential Therapeutic Target in Autoimmune Diseases.
Shen P, Deng X, Chen Z, Ba X, Qin K, Huang Y, Huang Y, Li T, Yan J, Tu S. Shen P, et al. Front Immunol. 2021 Nov 23;12:779177. doi: 10.3389/fimmu.2021.779177. eCollection 2021. Front Immunol. 2021. PMID: 34887866 Free PMC article. Review.
The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide, and the identification of novel therapeutic strategies for prevention and treatment is urgently needed. Sirtuin 1 (SIRT1), a member of the class III family of nicotinamid …
The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide, and the identification of novel therapeutic strateg …
Nutraceutical activation of Sirt1: a review.
DiNicolantonio JJ, McCarty MF, O'Keefe JH. DiNicolantonio JJ, et al. Open Heart. 2022 Dec;9(2):e002171. doi: 10.1136/openhrt-2022-002171. Open Heart. 2022. PMID: 36522127 Free PMC article. Review.
The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several complementary effects on cellular function that are favourable to healthspan; it is often thought of as an 'anti-aging' enzyme. ...Since oxidative stress can reduc …
The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several complementary effects o …
SIRT1 and SIRT6: The role in aging-related diseases.
You Y, Liang W. You Y, et al. Biochim Biophys Acta Mol Basis Dis. 2023 Oct;1869(7):166815. doi: 10.1016/j.bbadis.2023.166815. Epub 2023 Jul 26. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 37499928 Free article. Review.
Sirtuins (SIRTs) are a family of NAD(+)-dependent enzymes that regulate fundamental biological functions from genomic stability and lifespan to energy metabolism and tumorigenesis. Of the seven mammalian SIRT isotypes (SIRT1-7), SIRT1 and SIRT6 are well-recognized f …
Sirtuins (SIRTs) are a family of NAD(+)-dependent enzymes that regulate fundamental biological functions from genomic stability and lifespan …
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer.
Alves-Fernandes DK, Jasiulionis MG. Alves-Fernandes DK, et al. Int J Mol Sci. 2019 Jun 28;20(13):3153. doi: 10.3390/ijms20133153. Int J Mol Sci. 2019. PMID: 31261609 Free PMC article. Review.
Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy, senescence, proliferation, aging, and tumorigenesis. ...SIRT1 upregulation has …
Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme deeply involved in gene regulatio …
SIRT1 Modulators in Experimentally Induced Liver Injury.
Farghali H, Kemelo MK, Canová NK. Farghali H, et al. Oxid Med Cell Longev. 2019 Jun 2;2019:8765954. doi: 10.1155/2019/8765954. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31281594 Free PMC article. Review.
A combination of D-galactosamine and lipopolysaccharide (D-GalN/LPS) downregulated SIRT1 expression, while SIRT1 activators, SRT1720, resveratrol, and quercetin, upregulated SIRT1 and alleviated D-GalN/LPS-induced acute hepatotoxicity. ...Together, all these …
A combination of D-galactosamine and lipopolysaccharide (D-GalN/LPS) downregulated SIRT1 expression, while SIRT1 activators, S …
Targeting SIRT1-regulated autophagic cell death as a novel therapeutic avenue for cancer prevention.
Patra S, Praharaj PP, Singh A, Bhutia SK. Patra S, et al. Drug Discov Today. 2023 Sep;28(9):103692. doi: 10.1016/j.drudis.2023.103692. Epub 2023 Jun 26. Drug Discov Today. 2023. PMID: 37379905 Review.
Cellular localization and deacetylation activity of sirtuin 1 (SIRT1) has a significant role in cancer regulation. The multifactorial role of SIRT1 in autophagy regulates several cancer-associated cellular phenotypes, aiding cellular survival and cell …
Cellular localization and deacetylation activity of sirtuin 1 (SIRT1) has a significant role in cancer regulation. The …
SIRT1: a potential tumour biomarker and therapeutic target.
Zhao B, Li X, Zhou L, Wang Y, Shang P. Zhao B, et al. J Drug Target. 2019 Dec;27(10):1046-1052. doi: 10.1080/1061186X.2019.1605519. Epub 2019 May 6. J Drug Target. 2019. PMID: 31056963 Review.
Numerous studies have found that SIRT1 is highly expressed in a broad range of tumours compared with the paracancerous tissue. ...Herein, we focus on the roles of SIRT1 in cancers and summarise the potential use of SIRT1 as a promising tumour biomarker or the …
Numerous studies have found that SIRT1 is highly expressed in a broad range of tumours compared with the paracancerous tissue. ...Her …
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