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Page 1
Mast cells, glia and neuroinflammation: partners in crime?
Skaper SD, Facci L, Giusti P. Skaper SD, et al. Immunology. 2014 Mar;141(3):314-27. doi: 10.1111/imm.12170. Immunology. 2014. PMID: 24032675 Free PMC article. Review.
Microglia respond also to pro-inflammatory signals released from other non-neuronal cells, mainly those of immune origin such as mast cells. The latter are found in most tissues, are CNS resident, and traverse the blood-spinal cord and blood-brain barr …
Microglia respond also to pro-inflammatory signals released from other non-neuronal cells, mainly those of immune origin such …
Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator.
Skaper SD, Facci L, Giusti P. Skaper SD, et al. Mol Neurobiol. 2013 Oct;48(2):340-52. doi: 10.1007/s12035-013-8487-6. Epub 2013 Jun 28. Mol Neurobiol. 2013. PMID: 23813098 Review.
A proposed mast cell-glia communication may open new perspectives for designing therapies to target neuroinflammation by differentially modulating activation of non-neuronal cells normally controlling neuronal sensitization-both peripherally and centra …
A proposed mast cell-glia communication may open new perspectives for designing therapies to target neuroinflammation by differential …
Degenerative Joint Diseases and Neuroinflammation.
Fusco M, Skaper SD, Coaccioli S, Varrassi G, Paladini A. Fusco M, et al. Among authors: skaper sd. Pain Pract. 2017 Apr;17(4):522-532. doi: 10.1111/papr.12551. Epub 2017 Feb 10. Pain Pract. 2017. PMID: 28039964 Review.
The pathogenesis underlying joint diseases remains unclear; however, it is currently believed that cross-talk between cartilage and subchondral bone-and loss of balance between these two structures in joint diseases-is a critical element. This view is amplified by the presence of …
The pathogenesis underlying joint diseases remains unclear; however, it is currently believed that cross-talk between cartilage and subchond …
An Inflammation-Centric View of Neurological Disease: Beyond the Neuron.
Skaper SD, Facci L, Zusso M, Giusti P. Skaper SD, et al. Front Cell Neurosci. 2018 Mar 21;12:72. doi: 10.3389/fncel.2018.00072. eCollection 2018. Front Cell Neurosci. 2018. PMID: 29618972 Free PMC article. Review.
Immune cell-derived inflammatory molecules are critical for regulation of host responses to inflammation. Although these mediators can originate from various non-neuronal cells, important sources in the above neuropathologies appear to be microglia and mast
Immune cell-derived inflammatory molecules are critical for regulation of host responses to inflammation. Although these mediators can origi …
Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide.
Skaper SD, Facci L. Skaper SD, et al. Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3312-25. doi: 10.1098/rstb.2011.0391. Philos Trans R Soc Lond B Biol Sci. 2012. PMID: 23108549 Free PMC article. Review.
In this context, mast cells are of particular relevance. These immune-related cells, while resident in the CNS, are able to cross a compromised blood-spinal cord and blood-brain barrier in cases of CNS pathology. Emerging evidence suggests the possibility of …
In this context, mast cells are of particular relevance. These immune-related cells, while resident in the CNS, are abl …
Impact of Inflammation on the Blood-Neural Barrier and Blood-Nerve Interface: From Review to Therapeutic Preview.
Skaper SD. Skaper SD. Int Rev Neurobiol. 2017;137:29-45. doi: 10.1016/bs.irn.2017.08.004. Epub 2017 Oct 16. Int Rev Neurobiol. 2017. PMID: 29132542 Review.
Being close also to the perivasculature and on the brain side of the BBB, the mast cell is well positioned to disrupt BBB function. Interestingly, tissue damage and/or stress activates homeostatic mechanisms/molecules expressed by mast cells and microglia, an …
Being close also to the perivasculature and on the brain side of the BBB, the mast cell is well positioned to disrupt BBB function. I …
Chronic Pain in the Elderly: The Case for New Therapeutic Strategies.
Paladini A, Fusco M, Coaccioli S, Skaper SD, Varrassi G. Paladini A, et al. Among authors: skaper sd. Pain Physician. 2015 Sep-Oct;18(5):E863-76. Pain Physician. 2015. PMID: 26431140 Free article. Review.
Since these cells are the primary interlocutors for pain neurons, their alterations lead to changes that promote persistent neuroinflammation, thereby impacting pain neuronal cell functionality. ...CONCLUSION: Non-neuronal cells of immune system …
Since these cells are the primary interlocutors for pain neurons, their alterations lead to changes that promote persistent ne …
N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution.
Skaper SD, Facci L, Barbierato M, Zusso M, Bruschetta G, Impellizzeri D, Cuzzocrea S, Giusti P. Skaper SD, et al. Mol Neurobiol. 2015 Oct;52(2):1034-42. doi: 10.1007/s12035-015-9253-8. Epub 2015 Jun 9. Mol Neurobiol. 2015. PMID: 26055231 Review.
Glia, key players in such nervous system disorders, are not only capable of expressing a pro-inflammatory phenotype but respond also to inflammatory signals released from cells of immune origin such as mast cells. Chronic inflammatory processes may be counter …
Glia, key players in such nervous system disorders, are not only capable of expressing a pro-inflammatory phenotype but respond also to infl …
Palmitoylethanolamide, a naturally occurring disease-modifying agent in neuropathic pain.
Skaper SD, Facci L, Fusco M, Della Valle MF, Zusso M, Costa B, Giusti P. Skaper SD, et al. Inflammopharmacology. 2014 Apr;22(2):79-94. doi: 10.1007/s10787-013-0191-7. Epub 2013 Nov 1. Inflammopharmacology. 2014. PMID: 24178954 Review.
This review discusses a novel approach to neuropathic pain management, based on knowledge of: the role of glia and mast cells in pain and neuroinflammation; the body's innate mechanisms to maintain cellular homeostasis when faced with external stressors provoking, f …
This review discusses a novel approach to neuropathic pain management, based on knowledge of: the role of glia and mast cells
Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.
Facci L, Dal Toso R, Romanello S, Buriani A, Skaper SD, Leon A. Facci L, et al. Among authors: skaper sd. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3376-80. doi: 10.1073/pnas.92.8.3376. Proc Natl Acad Sci U S A. 1995. PMID: 7724569 Free PMC article.
Here we report that mast cells express both the gene and a functional CB2 receptor protein with negative regulatory effects on mast cell activation. ...The results suggest that (i) peripheral cannabinoid CB2 receptors control, upon agonist binding, mast
Here we report that mast cells express both the gene and a functional CB2 receptor protein with negative regulatory effects on …
16 results