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Page 1
Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator.
Skaper SD, Facci L, Giusti P. Skaper SD, et al. Mol Neurobiol. 2013 Oct;48(2):340-52. doi: 10.1007/s12035-013-8487-6. Epub 2013 Jun 28. Mol Neurobiol. 2013. PMID: 23813098 Review.
A proposed mast cell-glia communication may open new perspectives for designing therapies to target neuroinflammation by differentially modulating activation of non-neuronal cells normally controlling neuronal sensitization-both peripherally and centra …
A proposed mast cell-glia communication may open new perspectives for designing therapies to target neuroinflammation by differential …
Mast cells, glia and neuroinflammation: partners in crime?
Skaper SD, Facci L, Giusti P. Skaper SD, et al. Immunology. 2014 Mar;141(3):314-27. doi: 10.1111/imm.12170. Immunology. 2014. PMID: 24032675 Free PMC article. Review.
Microglia respond also to pro-inflammatory signals released from other non-neuronal cells, mainly those of immune origin such as mast cells. The latter are found in most tissues, are CNS resident, and traverse the blood-spinal cord and blood-brain barr …
Microglia respond also to pro-inflammatory signals released from other non-neuronal cells, mainly those of immune origin such …
Degenerative Joint Diseases and Neuroinflammation.
Fusco M, Skaper SD, Coaccioli S, Varrassi G, Paladini A. Fusco M, et al. Among authors: skaper sd. Pain Pract. 2017 Apr;17(4):522-532. doi: 10.1111/papr.12551. Epub 2017 Feb 10. Pain Pract. 2017. PMID: 28039964 Review.
This view is amplified by the presence of mast cells, whose dysregulation is associated with alterations of junction structures (cartilage, bone, synovia, matrix, nerve endings, and blood vessels). In addition, persistent activation of mast cells facil …
This view is amplified by the presence of mast cells, whose dysregulation is associated with alterations of junction structure …
An Inflammation-Centric View of Neurological Disease: Beyond the Neuron.
Skaper SD, Facci L, Zusso M, Giusti P. Skaper SD, et al. Front Cell Neurosci. 2018 Mar 21;12:72. doi: 10.3389/fncel.2018.00072. eCollection 2018. Front Cell Neurosci. 2018. PMID: 29618972 Free PMC article. Review.
Although these mediators can originate from various non-neuronal cells, important sources in the above neuropathologies appear to be microglia and mast cells, together with astrocytes and possibly also oligodendrocytes. Understanding neuroinflam …
Although these mediators can originate from various non-neuronal cells, important sources in the above neuropathologies appear …
Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide.
Skaper SD, Facci L. Skaper SD, et al. Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3312-25. doi: 10.1098/rstb.2011.0391. Philos Trans R Soc Lond B Biol Sci. 2012. PMID: 23108549 Free PMC article. Review.
Both astroglia and microglia, in particular, constitute an important source of inflammatory mediators and may have fundamental roles in central nervous system (CNS) disorders from neuropathic pain and epilepsy to neurodegenerative diseases. Glial cells respond also to pro- …
Both astroglia and microglia, in particular, constitute an important source of inflammatory mediators and may have fundamental roles in cent …
Chronic Pain in the Elderly: The Case for New Therapeutic Strategies.
Paladini A, Fusco M, Coaccioli S, Skaper SD, Varrassi G. Paladini A, et al. Among authors: skaper sd. Pain Physician. 2015 Sep-Oct;18(5):E863-76. Pain Physician. 2015. PMID: 26431140 Free article. Review.
Furthermore, different changes concern immune system cells, such as mast cells and microglia, that with age show an increase in their sensitivity to noxious stimuli and a decreased capability to be regulated by homeostatic endogenous systems. ...CONCLUSION: N …
Furthermore, different changes concern immune system cells, such as mast cells and microglia, that with age show an inc …
N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution.
Skaper SD, Facci L, Barbierato M, Zusso M, Bruschetta G, Impellizzeri D, Cuzzocrea S, Giusti P. Skaper SD, et al. Mol Neurobiol. 2015 Oct;52(2):1034-42. doi: 10.1007/s12035-015-9253-8. Epub 2015 Jun 9. Mol Neurobiol. 2015. PMID: 26055231 Review.
Glia, key players in such nervous system disorders, are not only capable of expressing a pro-inflammatory phenotype but respond also to inflammatory signals released from cells of immune origin such as mast cells. Chronic inflammatory processes may be counter …
Glia, key players in such nervous system disorders, are not only capable of expressing a pro-inflammatory phenotype but respond also to infl …
Impact of Inflammation on the Blood-Neural Barrier and Blood-Nerve Interface: From Review to Therapeutic Preview.
Skaper SD. Skaper SD. Int Rev Neurobiol. 2017;137:29-45. doi: 10.1016/bs.irn.2017.08.004. Epub 2017 Oct 16. Int Rev Neurobiol. 2017. PMID: 29132542 Review.
Being close also to the perivasculature and on the brain side of the BBB, the mast cell is well positioned to disrupt BBB function. Interestingly, tissue damage and/or stress activates homeostatic mechanisms/molecules expressed by mast cells and microglia, an …
Being close also to the perivasculature and on the brain side of the BBB, the mast cell is well positioned to disrupt BBB function. I …
Palmitoylethanolamide, a naturally occurring disease-modifying agent in neuropathic pain.
Skaper SD, Facci L, Fusco M, Della Valle MF, Zusso M, Costa B, Giusti P. Skaper SD, et al. Inflammopharmacology. 2014 Apr;22(2):79-94. doi: 10.1007/s10787-013-0191-7. Epub 2013 Nov 1. Inflammopharmacology. 2014. PMID: 24178954 Review.
This review discusses a novel approach to neuropathic pain management, based on knowledge of: the role of glia and mast cells in pain and neuroinflammation; the body's innate mechanisms to maintain cellular homeostasis when faced with external stressors provoking, f …
This review discusses a novel approach to neuropathic pain management, based on knowledge of: the role of glia and mast cells …
Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.
Facci L, Dal Toso R, Romanello S, Buriani A, Skaper SD, Leon A. Facci L, et al. Among authors: skaper sd. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3376-80. doi: 10.1073/pnas.92.8.3376. Proc Natl Acad Sci U S A. 1995. PMID: 7724569 Free PMC article.
As a second cannabinoid receptor (CB2) has been found in peripheral tissues, the possible presence of CB2 receptors on mast cells and their interaction with N-acylamides was investigated. Here we report that mast cells express both the gene and a funct …
As a second cannabinoid receptor (CB2) has been found in peripheral tissues, the possible presence of CB2 receptors on mast cells …
16 results