A prefrontal-paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice.
Yamamuro K, Bicks LK, Leventhal MB, Kato D, Im S, Flanigan ME, Garkun Y, Norman KJ, Caro K, Sadahiro M, Kullander K, Akbarian S, Russo SJ, Morishita H.
Yamamuro K, et al.
Nat Neurosci. 2020 Oct;23(10):1240-1252. doi: 10.1038/s41593-020-0695-6. Epub 2020 Aug 31.
Nat Neurosci. 2020.
PMID: 32868932
Free PMC article.
Juvenile isolation led to both reduced excitability of mPFCpPVT neurons and increased inhibitory input drive from low-threshold-spiking somatostatin interneurons in adulthood, suggesting a circuit mechanism underlying sociability deficits. ...
Juvenile isolation led to both reduced excitability of mPFCpPVT neurons and increased inhibitory input drive from low-threshold-spiking s …