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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1800 1
1900 1
1903 1
1909 1
1913 1
1914 1
1920 1
1921 1
1922 4
1923 4
1924 2
1925 1
1926 2
1927 1
1928 3
1930 2
1933 1
1935 1
1938 1
1939 1
1942 1
1944 3
1945 5
1946 3
1947 2
1948 6
1949 2
1950 11
1951 6
1952 2
1953 11
1954 15
1955 6
1956 7
1957 5
1958 10
1959 7
1960 3
1961 5
1962 7
1963 11
1964 8
1965 12
1966 8
1967 20
1968 9
1969 17
1970 13
1971 10
1972 10
1973 15
1974 13
1975 80
1976 70
1977 73
1978 77
1979 57
1980 69
1981 68
1982 99
1983 91
1984 108
1985 111
1986 119
1987 118
1988 107
1989 190
1990 174
1991 173
1992 158
1993 203
1994 195
1995 199
1996 223
1997 237
1998 237
1999 248
2000 239
2001 267
2002 270
2003 296
2004 341
2005 399
2006 410
2007 419
2008 492
2009 447
2010 529
2011 526
2012 571
2013 604
2014 696
2015 684
2016 705
2017 748
2018 754
2019 821
2020 943
2021 1042
2022 1016
2023 902
2024 305

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16,677 results

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Page 1
Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery.
Wang X, Liu S, Sun Y, Yu X, Lee SM, Cheng Q, Wei T, Gong J, Robinson J, Zhang D, Lian X, Basak P, Siegwart DJ. Wang X, et al. Nat Protoc. 2023 Jan;18(1):265-291. doi: 10.1038/s41596-022-00755-x. Epub 2022 Oct 31. Nat Protoc. 2023. PMID: 36316378 Free PMC article. Review.
A new methodology termed selective organ targeting (SORT) was recently developed that enables controllable delivery of nucleic acids to target tissues. SORT lipid nanoparticles (LNPs) involve the inclusion of SORT molecules that accurately tune delivery to th …
A new methodology termed selective organ targeting (SORT) was recently developed that enables controllable delivery of nucleic acids …
Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing.
Cheng Q, Wei T, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ. Cheng Q, et al. Nat Nanotechnol. 2020 Apr;15(4):313-320. doi: 10.1038/s41565-020-0669-6. Epub 2020 Apr 6. Nat Nanotechnol. 2020. PMID: 32251383 Free PMC article.
Here, we report a strategy termed selective organ targeting (SORT) wherein multiple classes of lipid nanoparticles are systematically engineered to exclusively edit extrahepatic tissues via addition of a supplemental SORT molecule. Lung-, spleen- and liver-targeted …
Here, we report a strategy termed selective organ targeting (SORT) wherein multiple classes of lipid nanoparticles are systematically …
Spleen SORT LNP Generated in situ CAR T Cells Extend Survival in a Mouse Model of Lymphoreplete B Cell Lymphoma.
Álvarez-Benedicto E, Tian Z, Chatterjee S, Orlando D, Kim M, Guerrero ED, Wang X, Siegwart DJ. Álvarez-Benedicto E, et al. Angew Chem Int Ed Engl. 2023 Oct 26;62(44):e202310395. doi: 10.1002/anie.202310395. Epub 2023 Sep 18. Angew Chem Int Ed Engl. 2023. PMID: 37651468
Optimized Spleen SORT LNPs containing 10 % 18 : 1 PA transfected CD3+, CD8+, and CD4+ T cells in wild-type mice. Spleen SORT LNPs delivered Cre recombinase mRNA and CAR encoding mRNA to T cells in reporter mice and in a lymphoreplete B cell lymphoma model (respectiv …
Optimized Spleen SORT LNPs containing 10 % 18 : 1 PA transfected CD3+, CD8+, and CD4+ T cells in wild-type mice. Spleen SORT L …
The interplay of quaternary ammonium lipid structure and protein corona on lung-specific mRNA delivery by selective organ targeting (SORT) nanoparticles.
Dilliard SA, Sun Y, Brown MO, Sung YC, Chatterjee S, Farbiak L, Vaidya A, Lian X, Wang X, Lemoff A, Siegwart DJ. Dilliard SA, et al. J Control Release. 2023 Sep;361:361-372. doi: 10.1016/j.jconrel.2023.07.058. Epub 2023 Aug 10. J Control Release. 2023. PMID: 37536547
Mechanistic work revealed that the biophysical class of SORT molecule added to the LNP forms a distinct protein corona that helps determine where in the body mRNA is delivered. To better understand which plasma proteins could drive tissue-specific mRNA delivery, we charact …
Mechanistic work revealed that the biophysical class of SORT molecule added to the LNP forms a distinct protein corona that helps det …
On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles.
Dilliard SA, Cheng Q, Siegwart DJ. Dilliard SA, et al. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2109256118. doi: 10.1073/pnas.2109256118. Proc Natl Acad Sci U S A. 2021. PMID: 34933999 Free PMC article.
SORT nanoparticles include a supplemental SORT molecule whose chemical structure determines the LNP's tissue-specific activity. ...We discovered that the chemical nature of the added SORT molecule controlled biodistribution, global/apparent pK(a), and serum p …
SORT nanoparticles include a supplemental SORT molecule whose chemical structure determines the LNP's tissue-specific activity …
Intelligent sort-timing prediction for image-activated cell sorting.
Zhao Y, Isozaki A, Herbig M, Hayashi M, Hiramatsu K, Yamazaki S, Kondo N, Ohnuki S, Ohya Y, Nitta N, Goda K. Zhao Y, et al. Cytometry A. 2023 Jan;103(1):88-97. doi: 10.1002/cyto.a.24664. Epub 2022 Jun 29. Cytometry A. 2023. PMID: 35766305 Free article.
This AI-on-a-chip technology combines fluorescence microscopy, AI-based image processing, sort-timing prediction, and cell sorting. Sort-timing prediction is particularly essential due to the latency on the order of milliseconds between image acquisition and sort …
This AI-on-a-chip technology combines fluorescence microscopy, AI-based image processing, sort-timing prediction, and cell sorting. …
DNA nanotechnology: DNA robots that sort cargoes.
Sun W. Sun W. Nat Nanotechnol. 2017 Dec;12(12):1120. doi: 10.1038/nnano.2017.236. Epub 2017 Dec 6. Nat Nanotechnol. 2017. PMID: 29209013 Review. No abstract available.
A Review of the Efficacy and Role of the Card Sort Exercise in the Treatment of Bipolar Disorder.
Tern PJW, Abdaal A, Tobin J, Macfarland K, Hunt M, Agius M. Tern PJW, et al. Psychiatr Danub. 2017 Sep;29(Suppl 3):183-193. Psychiatr Danub. 2017. PMID: 28953761 Review.
Few studies involve the card sort exercise, and those that do paired it with other early therapeutic interventions, such that it was difficult to assess the true contribution of the card sort exercise alone to outcome measures such as time-to-relapse or hospitalisat …
Few studies involve the card sort exercise, and those that do paired it with other early therapeutic interventions, such that it was …
The Science of Comedy (Sort of).
Libera A. Libera A. AMA J Ethics. 2020 Jul 1;22(7):E602-607. doi: 10.1001/amajethics.2020.602. AMA J Ethics. 2020. PMID: 32744229 Free article.
Evaluation of Sort Recovery via Rmax.
Perez-Gonzalez A, Lopes T, Martinez L, Bispo C, Gardner R, Riddell A. Perez-Gonzalez A, et al. Curr Protoc. 2024 Feb;4(2):e986. doi: 10.1002/cpz1.986. Curr Protoc. 2024. PMID: 38363042
The purity provides checks on sample quality, acquisition settings, gating strategy, and the sort decisions made by the instrument, but alone it is not sufficient to evaluate sorting performance. ...Because the sorted fraction is not perturbed, we can calculate Rmax during …
The purity provides checks on sample quality, acquisition settings, gating strategy, and the sort decisions made by the instrument, b …
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