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Active site architecture of coproporphyrin ferrochelatase with its physiological substrate coproporphyrin III: Propionate interactions and porphyrin core deformation.
Dali A, Gabler T, Sebastiani F, Destinger A, Furtmüller PG, Pfanzagl V, Becucci M, Smulevich G, Hofbauer S. Dali A, et al. Among authors: hofbauer s. Protein Sci. 2023 Jan;32(1):e4534. doi: 10.1002/pro.4534. Protein Sci. 2023. PMID: 36479958 Free PMC article.
This pathway was identified in 2015 and revealed that the correct substrate for these ferrochelatases is coproporphyrin III (cpIII) instead of protoporphyrin IX, as believed prior the discovery of the CPD pathway. The chemistry of cpIII, which has four propionates, differs …
This pathway was identified in 2015 and revealed that the correct substrate for these ferrochelatases is coproporphyrin III (cpIII) instead …
Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme b.
Milazzo L, Gabler T, Pühringer D, Jandova Z, Maresch D, Michlits H, Pfanzagl V, Djinović-Carugo K, Oostenbrink C, Furtmüller PG, Obinger C, Smulevich G, Hofbauer S. Milazzo L, et al. Among authors: hofbauer s. ACS Catal. 2019 Aug 2;9(8):6766-6782. doi: 10.1021/acscatal.9b00963. Epub 2019 Jun 18. ACS Catal. 2019. PMID: 31423350 Free PMC article.
Redox thermodynamics of B-class dye-decolorizing peroxidases.
Pfanzagl V, Bellei M, Hofbauer S, Laurent CVFP, Furtmüller PG, Oostenbrink C, Battistuzzi G, Obinger C. Pfanzagl V, et al. Among authors: hofbauer s. J Inorg Biochem. 2019 Oct;199:110761. doi: 10.1016/j.jinorgbio.2019.110761. Epub 2019 Jul 11. J Inorg Biochem. 2019. PMID: 31325671 Free article.
Monomeric and homotrimeric solution structures of truncated human peroxidasin 1 variants.
Paumann-Page M, Tscheliessnig R, Sevcnikar B, Katz RS, Schwartz I, Hofbauer S, Pfanzagl V, Furtmüller PG, Obinger C. Paumann-Page M, et al. Among authors: hofbauer s. Biochim Biophys Acta Proteins Proteom. 2020 Jan;1868(1):140249. doi: 10.1016/j.bbapap.2019.07.002. Epub 2019 Jul 8. Biochim Biophys Acta Proteins Proteom. 2020. PMID: 31295557 Free article.
Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions.
Olivé M, Engvall M, Ravenscroft G, Cabrera-Serrano M, Jiao H, Bortolotti CA, Pignataro M, Lambrughi M, Jiang H, Forrest ARR, Benseny-Cases N, Hofbauer S, Obinger C, Battistuzzi G, Bellei M, Borsari M, Di Rocco G, Viola HM, Hool LC, Cladera J, Lagerstedt-Robinson K, Xiang F, Wredenberg A, Miralles F, Baiges JJ, Malfatti E, Romero NB, Streichenberger N, Vial C, Claeys KG, Straathof CSM, Goris A, Freyer C, Lammens M, Bassez G, Kere J, Clemente P, Sejersen T, Udd B, Vidal N, Ferrer I, Edström L, Wedell A, Laing NG. Olivé M, et al. Among authors: hofbauer s. Nat Commun. 2019 Mar 27;10(1):1396. doi: 10.1038/s41467-019-09111-2. Nat Commun. 2019. PMID: 30918256 Free PMC article.
Molecular Mechanism of Enzymatic Chlorite Detoxification: Insights from Structural and Kinetic Studies.
Schaffner I, Mlynek G, Flego N, Pühringer D, Libiseller-Egger J, Coates L, Hofbauer S, Bellei M, Furtmüller PG, Battistuzzi G, Smulevich G, Djinović-Carugo K, Obinger C. Schaffner I, et al. Among authors: hofbauer s. ACS Catal. 2017 Nov 3;7(11):7962-7976. doi: 10.1021/acscatal.7b01749. Epub 2017 Oct 13. ACS Catal. 2017. PMID: 29142780 Free PMC article.
Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation.
Grishkovskaya I, Paumann-Page M, Tscheliessnig R, Stampler J, Hofbauer S, Soudi M, Sevcnikar B, Oostenbrink C, Furtmüller PG, Djinović-Carugo K, Nauseef WM, Obinger C. Grishkovskaya I, et al. Among authors: hofbauer s. J Biol Chem. 2017 May 19;292(20):8244-8261. doi: 10.1074/jbc.M117.775031. Epub 2017 Mar 27. J Biol Chem. 2017. PMID: 28348079 Free PMC article.
Pre-steady-state Kinetics Reveal the Substrate Specificity and Mechanism of Halide Oxidation of Truncated Human Peroxidasin 1.
Paumann-Page M, Katz RS, Bellei M, Schwartz I, Edenhofer E, Sevcnikar B, Soudi M, Hofbauer S, Battistuzzi G, Furtmüller PG, Obinger C. Paumann-Page M, et al. Among authors: hofbauer s. J Biol Chem. 2017 Mar 17;292(11):4583-4592. doi: 10.1074/jbc.M117.775213. Epub 2017 Jan 31. J Biol Chem. 2017. PMID: 28154175 Free PMC article.
Chemistry and Molecular Dynamics Simulations of Heme b-HemQ and Coproheme-HemQ.
Hofbauer S, Dalla Sega M, Scheiblbrandner S, Jandova Z, Schaffner I, Mlynek G, Djinović-Carugo K, Battistuzzi G, Furtmüller PG, Oostenbrink C, Obinger C. Hofbauer S, et al. Biochemistry. 2016 Sep 27;55(38):5398-412. doi: 10.1021/acs.biochem.6b00701. Epub 2016 Sep 15. Biochemistry. 2016. PMID: 27599156 Free PMC article.
Clickable 4-Oxo-β-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes.
Ruivo EF, Gonçalves LM, Carvalho LA, Guedes RC, Hofbauer S, Brito JA, Archer M, Moreira R, Lucas SD. Ruivo EF, et al. Among authors: hofbauer s. ChemMedChem. 2016 Sep 20;11(18):2037-42. doi: 10.1002/cmdc.201600258. Epub 2016 Jul 28. ChemMedChem. 2016. PMID: 27465595
Herein we report a copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC, or 'click' chemistry) approach based on the 4-oxo-beta-lactam warhead that yielded potent HNE inhibitors containing a triazole moiety. ...
Herein we report a copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC, or 'click' chemistry) approach based on the 4-oxo- …
Eukaryotic Catalase-Peroxidase: The Role of the Trp-Tyr-Met Adduct in Protein Stability, Substrate Accessibility, and Catalysis of Hydrogen Peroxide Dismutation.
Gasselhuber B, Carpena X, Graf MM, Pirker KF, Nicolussi A, Sündermann A, Hofbauer S, Zamocky M, Furtmüller PG, Jakopitsch C, Oostenbrink C, Fita I, Obinger C. Gasselhuber B, et al. Among authors: hofbauer s. Biochemistry. 2015 Sep 8;54(35):5425-38. doi: 10.1021/acs.biochem.5b00831. Epub 2015 Aug 25. Biochemistry. 2015. PMID: 26290940
Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM.
Chromikova V, Mader A, Hofbauer S, Göbl C, Madl T, Gach JS, Bauernfried S, Furtmüller PG, Forthal DN, Mach L, Obinger C, Kunert R. Chromikova V, et al. Among authors: hofbauer s. Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1536-44. doi: 10.1016/j.bbapap.2015.02.018. Epub 2015 Mar 5. Biochim Biophys Acta. 2015. PMID: 25748881 Free PMC article.
Dimeric chlorite dismutase from the nitrogen-fixing cyanobacterium Cyanothece sp. PCC7425.
Schaffner I, Hofbauer S, Krutzler M, Pirker KF, Bellei M, Stadlmayr G, Mlynek G, Djinovic-Carugo K, Battistuzzi G, Furtmüller PG, Daims H, Obinger C. Schaffner I, et al. Among authors: hofbauer s. Mol Microbiol. 2015 Jun;96(5):1053-68. doi: 10.1111/mmi.12989. Epub 2015 Apr 6. Mol Microbiol. 2015. PMID: 25732258 Free PMC article.
Independent evolution of four heme peroxidase superfamilies.
Zámocký M, Hofbauer S, Schaffner I, Gasselhuber B, Nicolussi A, Soudi M, Pirker KF, Furtmüller PG, Obinger C. Zámocký M, et al. Among authors: hofbauer s. Arch Biochem Biophys. 2015 May 15;574:108-19. doi: 10.1016/j.abb.2014.12.025. Epub 2015 Jan 7. Arch Biochem Biophys. 2015. PMID: 25575902 Free PMC article.
Biochemical characterization of the major N-acetylmuramidase from Lactobacillus buchneri.
Anzengruber J, Courtin P, Claes IJJ, Debreczeny M, Hofbauer S, Obinger C, Chapot-Chartier MP, Vanderleyden J, Messner P, Schäffer C. Anzengruber J, et al. Among authors: hofbauer s. Microbiology (Reading). 2014 Aug;160(Pt 8):1807-1819. doi: 10.1099/mic.0.078162-0. Epub 2014 May 24. Microbiology (Reading). 2014. PMID: 24858286 Free PMC article.
Mechanism of reaction of chlorite with mammalian heme peroxidases.
Jakopitsch C, Pirker KF, Flemmig J, Hofbauer S, Schlorke D, Furtmüller PG, Arnhold J, Obinger C. Jakopitsch C, et al. Among authors: hofbauer s. J Inorg Biochem. 2014 Jun;135(100):10-9. doi: 10.1016/j.jinorgbio.2014.02.010. Epub 2014 Feb 28. J Inorg Biochem. 2014. PMID: 24632343 Free PMC article.
Inactivation of human myeloperoxidase by hydrogen peroxide.
Paumann-Page M, Furtmüller PG, Hofbauer S, Paton LN, Obinger C, Kettle AJ. Paumann-Page M, et al. Among authors: hofbauer s. Arch Biochem Biophys. 2013 Nov 1;539(1):51-62. doi: 10.1016/j.abb.2013.09.004. Epub 2013 Sep 11. Arch Biochem Biophys. 2013. PMID: 24035742 Free PMC article.