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Effects of hibernation on two important contractile tissues in tibetan frogs, Nanorana parkeri: a perspective from transcriptomics and metabolomics approaches.
Niu Y, Zhang X, Men S, Xu T, Zhang H, Li X, Storey KB, Chen Q. Niu Y, et al. Among authors: storey kb. BMC Genomics. 2024 May 8;25(1):454. doi: 10.1186/s12864-024-10357-4. BMC Genomics. 2024. PMID: 38720264
BACKGROUND: In response to seasonal cold and food shortage, the Xizang plateau frogs, Nanorana parkeri (Anura: Dicroglossidae), enter a reversible hypometabolic state where heart rate and oxygen consumption in skeletal muscle are strongly suppressed. ...
BACKGROUND: In response to seasonal cold and food shortage, the Xizang plateau frogs, Nanorana parkeri (Anura: Dicroglossidae), enter …
Hepatic transcriptome and gut microbiome provide insights into freeze tolerance in the high-altitude frog, Nanorana parkeri.
Niu Y, Li X, Zhang H, Xu T, Wei D, An Z, Storey KB. Niu Y, et al. Among authors: storey kb. Comp Biochem Physiol Part D Genomics Proteomics. 2023 Dec;48:101147. doi: 10.1016/j.cbd.2023.101147. Epub 2023 Oct 1. Comp Biochem Physiol Part D Genomics Proteomics. 2023. PMID: 37797475
Among amphibians, freeze tolerance is a low-temperature survival strategy that has been well studied in several species. One influence on animal health and survival under adverse conditions is the gut microbiome. Gut microbes can be greatly affected by temperature f …
Among amphibians, freeze tolerance is a low-temperature survival strategy that has been well studied in several species. One influenc …
Two-Fold ND5 Genes, Three-Fold Control Regions, lncRNA, and the "Missing" ATP8 Found in the Mitogenomes of Polypedates megacephalus (Rhacophridae: Polypedates).
Cai LN, Zhang LH, Lin YJ, Wang JY, Storey KB, Zhang JY, Yu DN. Cai LN, et al. Among authors: storey kb. Animals (Basel). 2023 Sep 8;13(18):2857. doi: 10.3390/ani13182857. Animals (Basel). 2023. PMID: 37760257 Free PMC article.
However, using the mitogenome, gene expression analysis was performed via RT-qPCR of liver samples and it was thus determined that COIII, ND2, ND4, and ND6 were reduced to 0.64 0.24, 0.55 0.34, 0.44 0.21 and 0.65 0.17, respectively, under low-temperature stress (8 C) as co …
However, using the mitogenome, gene expression analysis was performed via RT-qPCR of liver samples and it was thus determined that COIII, ND …
Histone H3 and H4 Modifications Point to Transcriptional Suppression as a Component of Winter Freeze Tolerance in the Gall Fly Eurosta solidaginis.
Bloskie T, Storey KB. Bloskie T, et al. Among authors: storey kb. Int J Mol Sci. 2023 Jun 15;24(12):10153. doi: 10.3390/ijms241210153. Int J Mol Sci. 2023. PMID: 37373302 Free PMC article.
Elevated nuclear levels of histone H4, but not histone H3, were also observed in response to both cold and freeze acclimation. Together, the present study provides evidence for epigenetic-mediated transcriptional suppression in support of the winter diapause state and free …
Elevated nuclear levels of histone H4, but not histone H3, were also observed in response to both cold and freeze acclimation. Togeth …
Characterization of Two Mitogenomes of Hyla sanchiangensis (Anura: Hylidae), with Phylogenetic Relationships and Selection Pressure Analyses of Hylidae.
Hong YH, Huang HM, Wu L, Storey KB, Zhang JY, Zhang YP, Yu DN. Hong YH, et al. Among authors: storey kb. Animals (Basel). 2023 May 10;13(10):1593. doi: 10.3390/ani13101593. Animals (Basel). 2023. PMID: 37238023 Free PMC article.
Based on the results, we hypothesized that the positive selection of Hyla and Dryophytes was due to their experience of cold stress in historical events, but more evidence is needed to support this conclusion....
Based on the results, we hypothesized that the positive selection of Hyla and Dryophytes was due to their experience of cold stress i …
Torpor-responsive microRNAs in the heart of the Monito del monte, Dromiciops gliroides.
Breedon SA, Varma A, Quintero-Galvis JF, Gaitán-Espitia JD, Mejías C, Nespolo RF, Storey KB. Breedon SA, et al. Among authors: storey kb. Biofactors. 2023 Sep-Oct;49(5):1061-1073. doi: 10.1002/biof.1976. Epub 2023 May 23. Biofactors. 2023. PMID: 37219063
The marsupial Monito del monte (Dromiciops gliroides) utilizes both daily and seasonal bouts of torpor to preserve energy and prolong survival during periods of cold and unpredictable food availability. Torpor involves changes in cellular metabolism, including specific cha …
The marsupial Monito del monte (Dromiciops gliroides) utilizes both daily and seasonal bouts of torpor to preserve energy and prolong surviv …
Role of NADP+-dependent isocitrate dehydrogenase from muscle tissue of Rana sylvatica in ROS defense during freeze-tolerance.
Mattice AMS, Varma A, Storey KB. Mattice AMS, et al. Among authors: storey kb. Biochimie. 2023 Jul;210:14-21. doi: 10.1016/j.biochi.2023.03.008. Epub 2023 Mar 21. Biochimie. 2023. PMID: 36958591
The wood frog, Rana sylvatica, employs freeze tolerance as a winter survival strategy in seasonally cold environments. At subzero temperatures, up to 65-70% of total body water can freeze in extracellular spaces, halting vital functions (breathing, heartbeat) and causing i …
The wood frog, Rana sylvatica, employs freeze tolerance as a winter survival strategy in seasonally cold environments. At subzero tem …
The regulation of m6A-related proteins during whole-body freezing of the freeze-tolerant wood frog.
Rehman S, Varma A, Gupta A, Storey KB. Rehman S, et al. Among authors: storey kb. Biochem Cell Biol. 2023 Feb 1;101(1):77-86. doi: 10.1139/bcb-2022-0164. Epub 2022 Dec 3. Biochem Cell Biol. 2023. PMID: 36462217
Survival in extreme conditions requires regulation at transcriptional and translational levels to activate prosurvival pathways. N6-methyladenosine (m(6)A) methylation is one of the most common RNA modifications, regulating transcript processing and translation by executin …
Survival in extreme conditions requires regulation at transcriptional and translational levels to activate prosurvival pathways. N6-methylad …
Hypoxia inducible factor-1α responds to freezing, anoxia and dehydration stresses in a freeze-tolerant frog.
Storey JM, Li Z, Storey KB. Storey JM, et al. Among authors: storey kb. Cryobiology. 2023 Mar;110:79-85. doi: 10.1016/j.cryobiol.2022.11.242. Epub 2022 Nov 26. Cryobiology. 2023. PMID: 36442660
The wood frog, Rana sylvatica (aka Lithobates sylvaticus) is the main model for studies of natural freeze tolerance among amphibians living in seasonally cold climates. During freezing, 65% of total body water can be converted to extracellular ice and this imposes both deh …
The wood frog, Rana sylvatica (aka Lithobates sylvaticus) is the main model for studies of natural freeze tolerance among amphibians living …
Chaperone proteins: universal roles in surviving environmental stress.
Storey JM, Storey KB. Storey JM, et al. Among authors: storey kb. Cell Stress Chaperones. 2023 Sep;28(5):455-466. doi: 10.1007/s12192-022-01312-x. Epub 2022 Nov 28. Cell Stress Chaperones. 2023. PMID: 36441380 Free PMC article. Review.
These highly conserved proteins have particularly important roles to play in dealing with disruptions of the proteome as a result of environmental stress since abiotic factors, including temperature, pressure, oxygen, water availability, and pollutants can readily disrupt …
These highly conserved proteins have particularly important roles to play in dealing with disruptions of the proteome as a result of environ …
Chili pepper extends lifespan in a concentration-dependent manner and confers cold resistance on Drosophila melanogaster cohorts by influencing specific metabolic pathways.
Semaniuk UV, Gospodaryov DV, Strilbytska OM, Kucharska AZ, Sokół-Łętowska A, Burdyliuk NI, Storey KB, Bayliak MM, Lushchak O. Semaniuk UV, et al. Among authors: storey kb. Food Funct. 2022 Aug 1;13(15):8313-8328. doi: 10.1039/d2fo00930g. Food Funct. 2022. PMID: 35842943
A characteristic of both fruit fly sexes that ate chili-supplemented food was an increased resistance to cold shock. Flies of both sexes had lower levels of hemolymph glucose when they ate food supplemented with low concentrations of chili powder, as compared with controls …
A characteristic of both fruit fly sexes that ate chili-supplemented food was an increased resistance to cold shock. Flies of both se …
DNA damage and repair responses to freezing and anoxia stresses in wood frogs, Rana sylvatica.
Lung ZD, Storey KB. Lung ZD, et al. Among authors: storey kb. J Therm Biol. 2022 Jul;107:103274. doi: 10.1016/j.jtherbio.2022.103274. Epub 2022 May 31. J Therm Biol. 2022. PMID: 35701025
Wood frogs, Rana sylvatica, endure the freezing of 65% of total body water while overwintering in cold climates, enduring not only internal ice formation but also long-term anoxia due to cessation of heartbeat and breathing. ...
Wood frogs, Rana sylvatica, endure the freezing of 65% of total body water while overwintering in cold climates, enduring not only in …
Peripheral circadian gene activity is altered during hibernation in the thirteen-lined ground squirrel.
Watts AJ, Storey KB. Watts AJ, et al. Among authors: storey kb. Cryobiology. 2022 Aug;107:48-56. doi: 10.1016/j.cryobiol.2022.05.003. Epub 2022 May 22. Cryobiology. 2022. PMID: 35613673
Many small mammals living in seasonally cold environments rely on hibernation, utilizing strong metabolic rate suppression and a slow consumption of adipose reserves to survive the winter months. ...Using 13-lined ground squirrels (Ictidomys tridecemlineatus) as the model, …
Many small mammals living in seasonally cold environments rely on hibernation, utilizing strong metabolic rate suppression and a slow …
Physiological Ecology of Winter Hibernation by the High-Altitude Frog Nanorana parkeri.
Niu Y, Chen Q, Storey KB, Teng L, Li X, Xu T, Zhang H. Niu Y, et al. Among authors: storey kb. Physiol Biochem Zool. 2022 May-Jun;95(3):201-211. doi: 10.1086/718764. Physiol Biochem Zool. 2022. PMID: 35175907
AbstractThe Xizang plateau frog, Nanorana parkeri (Anura: Dicroglossidae), enters a dormant state in the winter in response to seasonal cold and lack of food. To investigate the physiological and ecological characteristics of overwintering in this species, we measured habi …
AbstractThe Xizang plateau frog, Nanorana parkeri (Anura: Dicroglossidae), enters a dormant state in the winter in response to seasonal c …
Muscles in Winter: The Epigenetics of Metabolic Arrest.
Ingelson-Filpula WA, Storey KB. Ingelson-Filpula WA, et al. Among authors: storey kb. Epigenomes. 2021 Dec 16;5(4):28. doi: 10.3390/epigenomes5040028. Epigenomes. 2021. PMID: 34968252 Free PMC article. Review.
The winter months are challenging for many animal species, which often enter a state of dormancy or hypometabolism to "wait out" the cold weather, food scarcity, reduced daylight, and restricted mobility that can characterize the season. ...
The winter months are challenging for many animal species, which often enter a state of dormancy or hypometabolism to "wait out" the cold …
MicroRNA Cues from Nature: A Roadmap to Decipher and Combat Challenges in Human Health and Disease?
Singh G, Storey KB. Singh G, et al. Among authors: storey kb. Cells. 2021 Nov 30;10(12):3374. doi: 10.3390/cells10123374. Cells. 2021. PMID: 34943882 Free PMC article. Review.
Many animals must endure harsh environmental conditions in nature, including cold/freezing temperatures, oxygen limitation (anoxia/hypoxia), and food or water scarcity, often requiring them to revamp their metabolic organization, frequently on a seasonal or life stage basi …
Many animals must endure harsh environmental conditions in nature, including cold/freezing temperatures, oxygen limitation (anoxia/hy …
Metabolic responses of plasma to extreme environments in overwintering Tibetan frogs Nanorana parkeri: a metabolome integrated analysis.
Niu Y, Zhang X, Zhang H, Xu T, Zhu L, Storey KB, Chen Q. Niu Y, et al. Among authors: storey kb. Front Zool. 2021 Aug 28;18(1):41. doi: 10.1186/s12983-021-00428-7. Front Zool. 2021. PMID: 34454525 Free PMC article.
Living at high altitude on the Tibetan Plateau where winters are very cold, the frog Nanorana parkeri, survives in one of the most hostile environments on Earth but, to date, relatively little is known about the biochemical and physiological adjustments for overwintering b …
Living at high altitude on the Tibetan Plateau where winters are very cold, the frog Nanorana parkeri, survives in one of the most ho …
Role of MicroRNAs in Extreme Animal Survival Strategies.
Hadj-Moussa H, Hawkins LJ, Storey KB. Hadj-Moussa H, et al. Among authors: storey kb. Methods Mol Biol. 2022;2257:311-347. doi: 10.1007/978-1-0716-1170-8_16. Methods Mol Biol. 2022. PMID: 34432286
Additional topics discussed include transcription factor networks, temperature dependent miRNA-targeting, and novel species-specific and stress-specific miRNAs....
Additional topics discussed include transcription factor networks, temperature dependent miRNA-targeting, and novel species-specific …
The effect of long-term cold acclimation on redox state and antioxidant defense in the high-altitude frog, Nanorana pleskei.
Zhang X, Niu Y, Zhang H, Xu T, Zeng Q, Storey KB, Chen Q. Zhang X, et al. Among authors: storey kb. J Therm Biol. 2021 Jul;99:103008. doi: 10.1016/j.jtherbio.2021.103008. Epub 2021 May 30. J Therm Biol. 2021. PMID: 34420638
However, the effect of cold acclimation on oxidative stress and antioxidant defenses is still not well understood. ...Overall, our present study systematically describes the responses of antioxidant defenses to long-term cold acclimation and these findings contribut …
However, the effect of cold acclimation on oxidative stress and antioxidant defenses is still not well understood. ...Overall, our pr …
Epigenetic underpinnings of freeze avoidance in the goldenrod gall moth, Epiblema scudderiana.
Williamson SM, Ingelson-Filpula WA, Hadj-Moussa H, Storey KB. Williamson SM, et al. Among authors: storey kb. J Insect Physiol. 2021 Oct;134:104298. doi: 10.1016/j.jinsphys.2021.104298. Epub 2021 Aug 17. J Insect Physiol. 2021. PMID: 34411584
The goldenrod gall moth (Epiblema scudderiana) is a cold hardy insect that survives subzero temperatures during the winter by supercooling bodily fluids to approximately -40 C, allowing the insect to remain unfrozen despite the freezing temperatures. ...This study examined …
The goldenrod gall moth (Epiblema scudderiana) is a cold hardy insect that survives subzero temperatures during the winter by superco …
Hypothermia promotes mitochondrial elongation In cardiac cells via inhibition of Drp1.
Taylor D, Germano J, Song Y, Hadj-Moussa H, Marek-Iannucci S, Dhanji R, Sin J, Czer LSC, Storey KB, Gottlieb RA. Taylor D, et al. Among authors: storey kb. Cryobiology. 2021 Oct;102:42-55. doi: 10.1016/j.cryobiol.2021.07.013. Epub 2021 Jul 29. Cryobiology. 2021. PMID: 34331901
Silencing of TRPV1 in H9c2 cardiomyocytes reproduced the morphological and respirometric phenotype of hypothermia. This report demonstrates a novel mechanism of cold-induced inhibition of mitochondrial fission....
Silencing of TRPV1 in H9c2 cardiomyocytes reproduced the morphological and respirometric phenotype of hypothermia. This report demonstrates …
Markers of tissue remodeling and inflammation in the white and brown adipose tissues of a model hibernator.
Logan SM, Storey KB. Logan SM, et al. Among authors: storey kb. Cell Signal. 2021 Jun;82:109975. doi: 10.1016/j.cellsig.2021.109975. Epub 2021 Mar 9. Cell Signal. 2021. PMID: 33711429
Hibernator brown and white adipose tissue (BAT, WAT) are important to study in terms of their inflammatory profile and tissue remodeling mechanisms since controlled and natural regulation of these processes could inform new pharmacological interventions that limit oxidative stres …
Hibernator brown and white adipose tissue (BAT, WAT) are important to study in terms of their inflammatory profile and tissue remodeling mec …
Regulation of an important glycolytic enzyme, pyruvate kinase, through phosphorylation in the larvae of a species of freeze-tolerant insect, Eurosta solidaginis.
Abboud J, Green SR, Smolinski MB, Storey KB. Abboud J, et al. Among authors: storey kb. Insect Mol Biol. 2021 Apr;30(2):176-187. doi: 10.1111/imb.12687. Epub 2020 Dec 23. Insect Mol Biol. 2021. PMID: 33280175
The K(m) phosphoenolpyruvate (PEP) of frozen PK was 20% higher than that of control PK, whereas the V(max) of frozen PK was up to 50% lower than that of control PK at the lowest assay temperature, suggesting inhibition of the enzyme during the winter. ...
The K(m) phosphoenolpyruvate (PEP) of frozen PK was 20% higher than that of control PK, whereas the V(max) of frozen PK was up to 50% lower …
Proteomics of intracellular freezing survival.
Thorne MAS, Britovšek NK, Hawkins L, Lilley KS, Storey KB. Thorne MAS, et al. Among authors: storey kb. PLoS One. 2020 May 26;15(5):e0233048. doi: 10.1371/journal.pone.0233048. eCollection 2020. PLoS One. 2020. PMID: 32453791 Free PMC article.
Cold-inducible RNA-binding protein Cirp, but not Rbm3, may regulate transcript processing and protection in tissues of the hibernating ground squirrel.
Logan SM, Storey KB. Logan SM, et al. Among authors: storey kb. Cell Stress Chaperones. 2020 Nov;25(6):857-868. doi: 10.1007/s12192-020-01110-3. Epub 2020 Apr 19. Cell Stress Chaperones. 2020. PMID: 32307648 Free PMC article.
RNA-binding proteins (RBPs) have important roles in transcription, pre-mRNA processing/transport, mRNA degradation, translation, and non-coding RNA processing, among others. RBPs that are expressed in response to cold stress, such as Cirp and Rbm3, could regulate RNA stabi …
RNA-binding proteins (RBPs) have important roles in transcription, pre-mRNA processing/transport, mRNA degradation, translation, and non-cod …
Metabolic characteristics of overwintering by the high-altitude dwelling Xizang plateau frog, Nanorana parkeri.
Niu Y, Cao W, Storey KB, He J, Wang J, Zhang T, Tang X, Chen Q. Niu Y, et al. Among authors: storey kb. J Comp Physiol B. 2020 Jul;190(4):433-444. doi: 10.1007/s00360-020-01275-4. Epub 2020 Apr 9. J Comp Physiol B. 2020. PMID: 32274534
The Xizang plateau frog, Nanorana parkeri, has the highest altitudinal distribution of all frogs in the world and survives the cold of winter without feeding by entering into a hibernating state. ...We conclude that overwintering N. parkeri exhibit a seasonal, temperatu …
The Xizang plateau frog, Nanorana parkeri, has the highest altitudinal distribution of all frogs in the world and survives the cold o …
Angiogenic signaling in the lungs of a metabolically suppressed hibernating mammal (Ictidomys tridecemlineatus).
Logan SM, Storey KB. Logan SM, et al. Among authors: storey kb. PeerJ. 2019 Nov 18;7:e8116. doi: 10.7717/peerj.8116. eCollection 2019. PeerJ. 2019. PMID: 31763078 Free PMC article.
To conserve energy in times of limited resource availability, particularly during cold winters, hibernators suppress even the most basic of physiologic processes. Breathing rates decrease from 40 breaths/minute to less than 1 breath/min as they decrease body temperature …
To conserve energy in times of limited resource availability, particularly during cold winters, hibernators suppress even the most ba …
228 results