Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2020 4
2021 16
2022 3
2023 7
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

27 results

Results by year

Filters applied: . Clear all
Page 1
Suramin, penciclovir, and anidulafungin exhibit potential in the treatment of COVID-19 via binding to nsp12 of SARS-CoV-2.
Dey SK, Saini M, Dhembla C, Bhatt S, Rajesh AS, Anand V, Das HK, Kundu S. Dey SK, et al. J Biomol Struct Dyn. 2022;40(24):14067-14083. doi: 10.1080/07391102.2021.2000498. Epub 2021 Nov 16. J Biomol Struct Dyn. 2022. PMID: 34784490
COVID-19, for which no confirmed therapeutic agents are available, has claimed over 48,14,000 lives globally. ...In addition, recent experimental evidences indicate that these drugs exhibit antiviral efficacy against SARS-CoV-2. Such evidence, a …
COVID-19, for which no confirmed therapeutic agents are available, has claimed over 48,14,000 lives globally. ...In addition, …
Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function.
Boniardi I, Corona A, Basquin J, Basquin C, Milia J, Nagy I, Tramontano E, Zinzula L. Boniardi I, et al. Virus Res. 2023 Oct 15;336:199221. doi: 10.1016/j.virusres.2023.199221. Epub 2023 Sep 15. Virus Res. 2023. PMID: 37704176 Free PMC article.
The coronavirus disease 2019 (COVID-19) pandemic is fading, however its etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues posing - despite the availability of licensed vaccines - a global health threat, due t …
The coronavirus disease 2019 (COVID-19) pandemic is fading, however its etiologic agent severe acute respiratory syndrome coro …
Suramin Disturbs the Association of the N-Terminal Domain of SARS-CoV-2 Nucleocapsid Protein with RNA.
Guo C, Xu H, Li X, Yu J, Lin D. Guo C, et al. Molecules. 2023 Mar 10;28(6):2534. doi: 10.3390/molecules28062534. Molecules. 2023. PMID: 36985506 Free PMC article.
Suramin was originally used as an antiparasitic drug in clinics. Here, we demonstrate that suramin can bind to the N-terminal domain of SARS-CoV-2 nucleocapsid protein (N-NTD) and disturb its interaction with RNA. ...Our findings not only reveal …
Suramin was originally used as an antiparasitic drug in clinics. Here, we demonstrate that suramin can bind to the N-terminal …
Drug repositioning against COVID-19: a first line treatment.
Bibi N, Farid A, Gul S, Ali J, Amin F, Kalathiya U, Hupp T. Bibi N, et al. J Biomol Struct Dyn. 2022;40(23):12812-12826. doi: 10.1080/07391102.2021.1977698. Epub 2021 Sep 14. J Biomol Struct Dyn. 2022. PMID: 34519259 Free PMC article.
COVID-19 disease caused by the SARS-CoV-2 virus has shaken our health and wealth foundations. ...The present study was designed using knowledge of viral pathogenesis and pharmacodynamics of broad-spectrum antiviral agents (BSAAs). We carried out …
COVID-19 disease caused by the SARS-CoV-2 virus has shaken our health and wealth foundations. ...The pres …
Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions.
Kwon PS, Xu S, Oh H, Kwon SJ, Rodrigues AL, Feroz M, Fraser K, He P, Zhang F, Hong JJ, Linhardt RJ, Dordick JS. Kwon PS, et al. Commun Biol. 2023 Apr 8;6(1):387. doi: 10.1038/s42003-023-04789-z. Commun Biol. 2023. PMID: 37031303 Free PMC article.
SARS-CoV-2 receptor binding domains (RBDs) interact with both the ACE2 receptor and heparan sulfate on the surface of host cells to enhance SARS-CoV-2 infection. ...Specifically, heparan sulfate and suramin had enhanced preferentia …
SARS-CoV-2 receptor binding domains (RBDs) interact with both the ACE2 receptor and heparan sulfate on the surface of h …
Targeted Redesign of Suramin Analogs for Novel Antimicrobial Lead Development.
Dey D, Ramakumar S, Conn GL. Dey D, et al. J Chem Inf Model. 2021 Sep 27;61(9):4442-4454. doi: 10.1021/acs.jcim.1c00578. Epub 2021 Sep 13. J Chem Inf Model. 2021. PMID: 34516120
Using available structures, we investigated suramin's target diversity, confirming that suramin preferentially binds to protein pockets that are both positively charged and enriched in aromatic or leucine residues. ...Use of this new framework to design potentially …
Using available structures, we investigated suramin's target diversity, confirming that suramin preferentially binds to protei …
Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle.
Salgado-Benvindo C, Thaler M, Tas A, Ogando NS, Bredenbeek PJ, Ninaber DK, Wang Y, Hiemstra PS, Snijder EJ, van Hemert MJ. Salgado-Benvindo C, et al. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00900-20. doi: 10.1128/AAC.00900-20. Print 2020 Jul 22. Antimicrob Agents Chemother. 2020. PMID: 32513797 Free PMC article.
Here, we demonstrate that the antiparasitic drug suramin inhibits SARS-CoV-2 replication, protecting Vero E6 cells with a 50% effective concentration (EC(50)) of 20 muM, which is well below the maximum attainable level in human serum. ...In a primary h …
Here, we demonstrate that the antiparasitic drug suramin inhibits SARS-CoV-2 replication, protecting Vero E6 cel …
The Repurposed Drugs Suramin and Quinacrine Cooperatively Inhibit SARS-CoV-2 3CL(pro) In Vitro.
Eberle RJ, Olivier DS, Amaral MS, Gering I, Willbold D, Arni RK, Coronado MA. Eberle RJ, et al. Viruses. 2021 May 10;13(5):873. doi: 10.3390/v13050873. Viruses. 2021. PMID: 34068686 Free PMC article.
Since the first report of a new pneumonia disease in December 2019 (Wuhan, China) the WHO reported more than 148 million confirmed cases and 3.1 million losses globally up to now. The causative agent of COVID-19 (SARS-CoV-2) has spread worldwide …
Since the first report of a new pneumonia disease in December 2019 (Wuhan, China) the WHO reported more than 148 million confirmed cases and …
Biomedical Text Link Prediction for Drug Discovery: A Case Study with COVID-19.
McCoy K, Gudapati S, He L, Horlander E, Kartchner D, Kulkarni S, Mehra N, Prakash J, Thenot H, Vanga SV, Wagner A, White B, Mitchell CS. McCoy K, et al. Pharmaceutics. 2021 May 26;13(6):794. doi: 10.3390/pharmaceutics13060794. Pharmaceutics. 2021. PMID: 34073456 Free PMC article.
The recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as COVID-19, served as a case study to demonstrate the efficacy of link prediction modeling for drug discovery. ...Repurposed drugs included potentia …
The recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as COVID-19 …
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin.
Yin W, Luan X, Li Z, Zhou Z, Wang Q, Gao M, Wang X, Zhou F, Shi J, You E, Liu M, Wang Q, Jiang Y, Jiang H, Xiao G, Zhang L, Yu X, Zhang S, Eric Xu H. Yin W, et al. Nat Struct Mol Biol. 2021 Mar;28(3):319-325. doi: 10.1038/s41594-021-00570-0. Epub 2021 Mar 5. Nat Struct Mol Biol. 2021. PMID: 33674802
The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to ravage many countries worldwide. ...Our results provide a structural mechanism for a nonnucleotide inhibitor of the SARS-CoV-2 RdRp....
The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to ravage many countries w …
27 results