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Page 1
DNA-DNA interstrand cross-linking by 2,5-bis(1-aziridinyl)-3,6-bis(carbethoxyamino)-1,4-benzoquinone: covalent structure of the dG-to-dG cross-links in calf thymus DNA and a synthetic DNA duplex.
Alley SC, Hopkins PB. Alley SC, et al. Chem Res Toxicol. 1994 Sep-Oct;7(5):666-72. doi: 10.1021/tx00041a012. Chem Res Toxicol. 1994. PMID: 7841346
The products of the alkylation reaction of reduced 2,5-bis(1-aziridinyl)-3,6-bis(carbethoxyamino)-1,4-benzoquinone (AZQ, 1a) with duplex DNA were studied using calf thymus DNA and a synthetic oligodeoxynucleotide. Reaction of calf thymus DNA with a mixture of …
The products of the alkylation reaction of reduced 2,5-bis(1-aziridinyl)-3,6-bis(carbethoxyamino)-1,4-benzoquinone (AZQ, 1a) with duplex DNA …
Yeast Hsl7 (histone synthetic lethal 7) catalyses the in vitro formation of omega-N(G)-monomethylarginine in calf thymus histone H2A.
Miranda TB, Sayegh J, Frankel A, Katz JE, Miranda M, Clarke S. Miranda TB, et al. Biochem J. 2006 May 1;395(3):563-70. doi: 10.1042/BJ20051771. Biochem J. 2006. PMID: 16426232 Free PMC article.
We found that FLAG-tagged Hsl7 effectively catalyses the transfer of methyl groups from S-adenosyl-[methyl-3H]-L-methionine to calf thymus histone H2A. When the acid-hydrolysed radiolabelled protein products were separated by high-resolution cation-exchange chromato …
We found that FLAG-tagged Hsl7 effectively catalyses the transfer of methyl groups from S-adenosyl-[methyl-3H]-L-methionine to calf thymu …
Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA.
Upadhyaya P, Sturla SJ, Tretyakova N, Ziegel R, Villalta PW, Wang M, Hecht SS. Upadhyaya P, et al. Chem Res Toxicol. 2003 Feb;16(2):180-90. doi: 10.1021/tx0256376. Chem Res Toxicol. 2003. PMID: 12588189
Further evidence for the identity of 17 and 19 was obtained by mild acid hydrolysis, which converted them to the corresponding Gua bases 18 and 20, identified by comparison to synthetic standards. Neutral thermal hydrolysis of DNA that had been reacted with NNALCH(2)OAc pr …
Further evidence for the identity of 17 and 19 was obtained by mild acid hydrolysis, which converted them to the corresponding Gua bases 18 …
Specific adducts recognised by a monoclonal antibody against cisplatin-modified DNA.
Meczes EL, Azim-Araghi A, Ottley CJ, Pearson DG, Tilby MJ. Meczes EL, et al. Biochem Pharmacol. 2005 Dec 5;70(12):1717-25. doi: 10.1016/j.bcp.2005.09.025. Epub 2005 Nov 2. Biochem Pharmacol. 2005. PMID: 16259963
The nature of adducts recognised by CP9/19 on polymeric DNA were defined using synthetic deoxynucleotides reacted with cisplatin. Total adduct levels were determined by atomic absorption spectrometry. The nature of adducts formed were confirmed by analysis of enzymatic …
The nature of adducts recognised by CP9/19 on polymeric DNA were defined using synthetic deoxynucleotides reacted with cisplatin. Tot …
Isolation and structure of an intrastrand cross-link adduct of mitomycin C and DNA.
Bizanek R, McGuinness BF, Nakanishi K, Tomasz M. Bizanek R, et al. Biochemistry. 1992 Mar 31;31(12):3084-91. doi: 10.1021/bi00127a008. Biochemistry. 1992. PMID: 1554696
The MC-treated DNA was hydrolyzed enzymatically under certain conditions, and the new adduct was isolated from the hydrolysate by HPLC. Its structure was determined by ultraviolet and circular dichroism spectroscopy and chemical and enzymatic transformations conducted on m …
The MC-treated DNA was hydrolyzed enzymatically under certain conditions, and the new adduct was isolated from the hydrolysate by HPL …
Formation of DNA adducts with cholyl adenylate, a putative intermediate for biosynthesis of cholyl-CoA.
Takamura-Enya T, Mano N, Kawahara N, Goto J, Wakabayashi K. Takamura-Enya T, et al. Chem Res Toxicol. 2005 Nov;18(11):1715-20. doi: 10.1021/tx050159v. Chem Res Toxicol. 2005. PMID: 16300380
Structures of these base modified adducts were confirmed by direct comparison with synthetic compounds obtained from coupling reactions of cholic acid with each nucleoside in the presence of dicyclohexylcarbodiimide in pyridine at 70 degrees C. N4-Cholyl-2'-deoxycytidine w …
Structures of these base modified adducts were confirmed by direct comparison with synthetic compounds obtained from coupling reactio …
Detection of deoxyadenosine-4-aminobiphenyl adduct in DNA of human uroepithelial cells treated with N-hydroxy-4-aminobiphenyl following nuclease P1 enrichment and 32P-postlabeling analysis.
Hatcher JF, Swaminathan S. Hatcher JF, et al. Carcinogenesis. 1995 Feb;16(2):295-301. doi: 10.1093/carcin/16.2.295. Carcinogenesis. 1995. PMID: 7859361
Towards characterization of pdAp-ABP, we postlabeled the synthetic N-(deoxyadenosin-3'-phospho-8-yl)-4-aminobiphenyl (dAp-ABP) adduct to generate pdAp-ABP and determined its chromatographic (TLC and HPLC) properties and sensitivity to nuclease P1 digestion. ...To test whet …
Towards characterization of pdAp-ABP, we postlabeled the synthetic N-(deoxyadenosin-3'-phospho-8-yl)-4-aminobiphenyl (dAp-ABP) adduct …
Identification of N-(deoxyguanosin-8-yl)-4-azobiphenyl by (32)P-postlabeling analyses of DNA in human uroepithelial cells exposed to proximate metabolites of the environmental carcinogen 4-aminobiphenyl.
Hatcher JF, Swaminathan S. Hatcher JF, et al. Environ Mol Mutagen. 2002;39(4):314-22. doi: 10.1002/em.10079. Environ Mol Mutagen. 2002. PMID: 12112383
Based on proton NMR and mass spectroscopic analyses of the synthetic product, the chemical structure of the adduct has been identified as N-(deoxyguanosin-N(2)-yl)-4-azobiphenyl (dG-N==N-ABP). (32)P-Postlabeling analysis of the nuclease P1-enriched DNA hydrolysate o …
Based on proton NMR and mass spectroscopic analyses of the synthetic product, the chemical structure of the adduct has been identifie …
Identification of new DNA adducts in human bladder epithelia exposed to the proximate metabolite of 4-aminobiphenyl using 32P-postlabeling method.
Swaminathan S, Hatcher JF. Swaminathan S, et al. Chem Biol Interact. 2002 Feb 20;139(2):199-213. doi: 10.1016/s0009-2797(01)00300-3. Chem Biol Interact. 2002. PMID: 11823007
Autoradiography of D1 chromatogram of the postlabeled products of calf thymus DNA chemically interacted with N-OH-ABP under acidic conditions revealed two adducts, #1 and #2, with R(f) values of about 0.2 and 0.3, respectively. ...Adduct #2 was also detected in calf thy …
Autoradiography of D1 chromatogram of the postlabeled products of calf thymus DNA chemically interacted with N-OH-ABP under acidic co …
[Influence of enzymatic hydrolyzate of mussel meat on growth and some indicators of general adaptation syndrome in rats].
Sidorova IuS, Seliaskin KE, Zorin SN, Abramova LS, Mazo VK. Sidorova IuS, et al. Vopr Pitan. 2014;83(4):22-8. Vopr Pitan. 2014. PMID: 25549471 Russian.
The animals of control group 1 (n = 8 with initial body weight of 179.4 5.9 g) and experimental group 2 (n = 8, 176.3 4.5 g) received a semi synthetic diet; the animals of the experimental group 3 (n = 8, 177.6 4.0 g) received the same semi synthetic diet in which 5 …
The animals of control group 1 (n = 8 with initial body weight of 179.4 5.9 g) and experimental group 2 (n = 8, 176.3 4.5 g) received a semi …
16 results