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Page 1
Showing results for tenase
Your search for telnase retrieved no results
SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa.
Childers KC, Peters SC, Lollar P, Spencer HT, Doering CB, Spiegel PC. Childers KC, et al. Blood Adv. 2022 Jun 14;6(11):3240-3254. doi: 10.1182/bloodadvances.2021005874. Blood Adv. 2022. PMID: 35255502 Free PMC article.
The intrinsic tenase (Xase) complex, formed by factors (f) VIIIa and fIXa, forms on activated platelet surfaces and catalyzes the activation of factor X to Xa, stimulating thrombin production in the blood coagulation cascade. ...
The intrinsic tenase (Xase) complex, formed by factors (f) VIIIa and fIXa, forms on activated platelet surfaces and catalyzes the act …
Factor VIII A3 domain residues 1793-1795 represent a factor IXa-interactive site in the tenase complex.
Takeyama M, Furukawa S, Sasai K, Horiuchi K, Nogami K. Takeyama M, et al. Biochim Biophys Acta Gen Subj. 2023 Aug;1867(8):130381. doi: 10.1016/j.bbagen.2023.130381. Epub 2023 May 18. Biochim Biophys Acta Gen Subj. 2023. PMID: 37207906
BACKGROUND: Factor (F)VIII functions as a cofactor in the tenase complex responsible for conversion of FX to FXa by FIXa. Earlier studies indicated that one of the FIXa-binding sites is located in residues 1811-1818 (crucially F1816) of the FVIII A3 domain. ...
BACKGROUND: Factor (F)VIII functions as a cofactor in the tenase complex responsible for conversion of FX to FXa by FIXa. Earlier stu …
Site-specific functional roles of the Factor X activation peptide in the intrinsic tenase-mediated Factor X activation.
Carnbring Bonde A, Rosenørn Hansen S, Johansson E, Rose Bjelke J, Lund J. Carnbring Bonde A, et al. FEBS Lett. 2022 Jun;596(12):1567-1575. doi: 10.1002/1873-3468.14321. Epub 2022 Feb 28. FEBS Lett. 2022. PMID: 35181908 Free article.
Moreover, we identify an essential interaction site for Factor IXa (FIXa) between residues 22 and 30 (AP numbering) and find that the residues between 31 and 41 may provide an important interaction site for the intrinsic tenase complex, composed of Factor IXa (FIXa) and Fa …
Moreover, we identify an essential interaction site for Factor IXa (FIXa) between residues 22 and 30 (AP numbering) and find that the residu …
Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments.
Cai Y, Yang W, Li X, Zhou L, Wang Z, Lin L, Chen D, Zhao L, Li Z, Liu S, Yin R, Zuo Z, Gao N, Zhao J. Cai Y, et al. Carbohydr Polym. 2019 Nov 15;224:115146. doi: 10.1016/j.carbpol.2019.115146. Epub 2019 Aug 2. Carbohydr Polym. 2019. PMID: 31472868
Fucosylated glycosaminoglycan (FG), a glycosaminoglycan derivative containing distinct sulfated fucose (FucS) branches, displays potent anticoagulant activity by inhibiting the intrinsic tenase complex (iXase). Herein, AmFG, SvFG and HaFG from three species of sea cucumber …
Fucosylated glycosaminoglycan (FG), a glycosaminoglycan derivative containing distinct sulfated fucose (FucS) branches, displays potent anti …
Differences in wild-type- and R338L-tenase complex formation are at the root of R338L-factor IX assay discrepancies.
Foley JH, Shehu E, Riddell A, Gray E, Goodale A, Yu IM, Verhoef D, Little J, Shattock D, Kitchen S, Chowdary P, Corbau R, Nathwani AC. Foley JH, et al. Blood Adv. 2023 Feb 14;7(3):458-467. doi: 10.1182/bloodadvances.2022007435. Blood Adv. 2023. PMID: 35839077 Free PMC article.
Supplementing FX into CSA had the effect of dampening FIX-WT activity relative to R338L-FIX activity, suggesting that FX impairs WT tenase formation to a greater extent than R338L-FIX tenase. Our data describe the scale of R338L-FIX assay discrepancies and provide i …
Supplementing FX into CSA had the effect of dampening FIX-WT activity relative to R338L-FIX activity, suggesting that FX impairs WT tenas …
Coagulation factor VIIa binds to herpes simplex virus 1-encoded glycoprotein C forming a factor X-enhanced tenase complex oriented on membranes.
Lin BH, Sutherland MR, Rosell FI, Morrissey JH, Pryzdial ELG. Lin BH, et al. J Thromb Haemost. 2020 Jun;18(6):1370-1380. doi: 10.1111/jth.14790. Epub 2020 Apr 9. J Thromb Haemost. 2020. PMID: 32145149 Free PMC article.
Thus, infection in vivo is enhanced by virus surface TF. HSV1-encoded glycoprotein C (gC) is implicated in this tenase activity by providing viral FX binding sites and increasing FVIIa function in solution. ...RESULTS: IEM confirmed that gC, TF, and aPL are simultaneously …
Thus, infection in vivo is enhanced by virus surface TF. HSV1-encoded glycoprotein C (gC) is implicated in this tenase activity by pr …
Fibrin and cancer.
Costantini V, Zacharski LR. Costantini V, et al. Thromb Haemost. 1993 May 3;69(5):406-14. Thromb Haemost. 1993. PMID: 8322261 Review. No abstract available.
Substrate delivery mechanism and the role of membrane curvature in factor X activation by extrinsic tenase.
Kovalenko TA, Panteleev MA, Sveshnikova AN. Kovalenko TA, et al. J Theor Biol. 2017 Dec 21;435:125-133. doi: 10.1016/j.jtbi.2017.09.015. Epub 2017 Sep 19. J Theor Biol. 2017. PMID: 28935233
Membrane-bound enzyme complex of extrinsic tenase (VIIa/TF) is believed to be the primary activator of blood clotting in vivo. ...Here we construct a mechanism-driven computational model of FX activation by extrinsic tenase on the surface of phospholipid vesicles of …
Membrane-bound enzyme complex of extrinsic tenase (VIIa/TF) is believed to be the primary activator of blood clotting in vivo. ...Her …
Thrombin-activable factor X re-establishes an intrinsic amplification in tenase-deficient plasmas.
Louvain-Quintard VB, Bianchini EP, Calmel-Tareau C, Tagzirt M, Le Bonniec BF. Louvain-Quintard VB, et al. J Biol Chem. 2005 Dec 16;280(50):41352-9. doi: 10.1074/jbc.M507846200. Epub 2005 Oct 5. J Biol Chem. 2005. PMID: 16207719 Free article.
In an attempt to re-establish a cyclic amplification of prothrombin activation in the absence of tenase, we prepared a chimera of FX having fibrinopeptide A for the activation domain (FX(FpA)). ...Nevertheless, FX(FpA) allowed in vitro amplification of thrombin production, …
In an attempt to re-establish a cyclic amplification of prothrombin activation in the absence of tenase, we prepared a chimera of FX …
518 results