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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 2
1969 3
1970 4
1971 4
1972 2
1973 1
1974 9
1975 1
1976 1
1977 4
1978 1
1979 3
1980 11
1981 8
1982 41
1983 99
1984 143
1985 249
1986 292
1987 281
1988 302
1989 326
1990 328
1991 296
1992 297
1993 344
1994 333
1995 311
1996 316
1997 336
1998 281
1999 284
2000 264
2001 254
2002 204
2003 206
2004 217
2005 195
2006 196
2007 202
2008 189
2009 143
2010 127
2011 143
2012 169
2013 139
2014 123
2015 115
2016 136
2017 130
2018 115
2019 136
2020 122
2021 88
2022 93
2023 104
2024 41

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8,383 results

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Page 1
Transient Prenyltransferase-Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase.
Faylo JL, van Eeuwen T, Gupta K, Murakami K, Christianson DW. Faylo JL, et al. Biochemistry. 2022 Nov 1;61(21):2417-2430. doi: 10.1021/acs.biochem.2c00509. Epub 2022 Oct 13. Biochemistry. 2022. PMID: 36227241 Free PMC article.
Here, we use cryo-EM to show that proximally configured prenyltransferase-cyclase complexes are observable even in the absence of covalent cross-linking; moreover, such complexes can involve multiple cyclase domains. A conserved basic patch on the prenyltransferase …
Here, we use cryo-EM to show that proximally configured prenyltransferase-cyclase complexes are observable even in the absence of cov …
En route to terpene natural products utilizing supramolecular cyclase mimetics.
Zhang Q, Catti L, Syntrivanis LD, Tiefenbacher K. Zhang Q, et al. Nat Prod Rep. 2019 Dec 11;36(12):1619-1627. doi: 10.1039/c9np00003h. Nat Prod Rep. 2019. PMID: 31021352 Review.
Covering: literature up to 2018 Terpenes are a class of natural products characterized by remarkable structural diversity. Much of this diversity arises biosynthetically from a handful of linear precursors through the so-called tail-to-head terpene cyclization react …
Covering: literature up to 2018 Terpenes are a class of natural products characterized by remarkable structural diversity. Much of th …
Bacterial terpene cyclases.
Dickschat JS. Dickschat JS. Nat Prod Rep. 2016 Jan;33(1):87-110. doi: 10.1039/c5np00102a. Nat Prod Rep. 2016. PMID: 26563452 Review.
This review summarises the accumulated knowledge about characterised bacterial terpene cyclases. The structures of identified products and of crystallised enzymes are included, and the obtained insights into enzyme mechanisms are discussed. After a summary of mono-, …
This review summarises the accumulated knowledge about characterised bacterial terpene cyclases. The structures of identified …
A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds.
Moosmann P, Ecker F, Leopold-Messer S, Cahn JKB, Dieterich CL, Groll M, Piel J. Moosmann P, et al. Nat Chem. 2020 Oct;12(10):968-972. doi: 10.1038/s41557-020-0515-3. Epub 2020 Aug 10. Nat Chem. 2020. PMID: 32778689 Free PMC article.
Class II terpene cyclases, such as oxidosqualene and squalene-hopene cyclases, catalyse some of the most complex polycyclization reactions. ...Although single domain class I terpene cyclases have already been identified, the corresponding class …
Class II terpene cyclases, such as oxidosqualene and squalene-hopene cyclases, catalyse some of the most complex polycy …
Structure of the Repurposed Fungal Terpene Cyclase FlvF Implicated in the C-N Bond-Forming Reaction of Flavunoidine Biosynthesis.
Tararina MA, Yee DA, Tang Y, Christianson DW. Tararina MA, et al. Biochemistry. 2022 Sep 20;61(18):2014-2024. doi: 10.1021/acs.biochem.2c00335. Epub 2022 Aug 29. Biochemistry. 2022. PMID: 36037799 Free PMC article.
The fungal species Aspergillus flavus produces an alkaloid terpenoid, flavunoidine, through a hybrid biosynthetic pathway combining both terpene cyclase and nonribosomal peptide synthetase enzymes. Flavunoidine consists of a tetracyclic, oxygenated sesquiterpene cor …
The fungal species Aspergillus flavus produces an alkaloid terpenoid, flavunoidine, through a hybrid biosynthetic pathway combining both …
Discovery of non-squalene triterpenes.
Tao H, Lauterbach L, Bian G, Chen R, Hou A, Mori T, Cheng S, Hu B, Lu L, Mu X, Li M, Adachi N, Kawasaki M, Moriya T, Senda T, Wang X, Deng Z, Abe I, Dickschat JS, Liu T. Tao H, et al. Nature. 2022 Jun;606(7913):414-419. doi: 10.1038/s41586-022-04773-3. Epub 2022 Jun 1. Nature. 2022. PMID: 35650436 Free PMC article.
The cyclization mechanisms of TvTS and MpMS and the absolute configurations of their products were investigated in isotopic labelling experiments. Structural analyses of the terpene cyclase domain of TvTS and full-length MpMS provide detailed insights into their cat …
The cyclization mechanisms of TvTS and MpMS and the absolute configurations of their products were investigated in isotopic labelling experi …
A Cryptic Plant Terpene Cyclase Producing Unconventional 18- and 14-Membered Macrocyclic C(25) and C(20) Terpenoids with Immunosuppressive Activity.
Chen YG, Li DS, Ling Y, Liu YC, Zuo ZL, Gan LS, Luo SH, Hua J, Chen DY, Xu F, Li M, Guo K, Liu Y, Gershenzon J, Li SH. Chen YG, et al. Angew Chem Int Ed Engl. 2021 Nov 22;60(48):25468-25476. doi: 10.1002/anie.202110842. Epub 2021 Oct 28. Angew Chem Int Ed Engl. 2021. PMID: 34580976
A versatile terpene synthase (LcTPS2) producing unconventional macrocyclic terpenoids was characterized from Leucosceptrum canum. ...
A versatile terpene synthase (LcTPS2) producing unconventional macrocyclic terpenoids was characterized from Leucosceptrum canum. ...
Squalene-hopene cyclases.
Siedenburg G, Jendrossek D. Siedenburg G, et al. Appl Environ Microbiol. 2011 Jun;77(12):3905-15. doi: 10.1128/AEM.00300-11. Epub 2011 Apr 29. Appl Environ Microbiol. 2011. PMID: 21531832 Free PMC article. Review.
They are biochemically synthesized from linear precursors (squalene, 2,3-oxidosqualene) in only one enzymatic step that is catalyzed by squalene-hopene cyclase (SHC) or oxidosqualene cyclase (OSC). SHCs and OSCs are related in amino acid sequences and probably are d …
They are biochemically synthesized from linear precursors (squalene, 2,3-oxidosqualene) in only one enzymatic step that is catalyzed by squa …
Silent catalytic promiscuity in the high-fidelity terpene cyclase delta-cadinene synthase.
Loizzi M, Miller DJ, Allemann RK. Loizzi M, et al. Org Biomol Chem. 2019 Jan 31;17(5):1206-1214. doi: 10.1039/c8ob02821d. Org Biomol Chem. 2019. PMID: 30652178 Free PMC article.
These compounds were also shown to be potent inhibitors of the 1,6-cyclase amorpha-4,11-diene synthase but not of the 1,10-cyclase aristolochene synthase from Penicillium roquefortii, demonstrating that the 1,6-cyclase activity of DCS is most likely an inhere …
These compounds were also shown to be potent inhibitors of the 1,6-cyclase amorpha-4,11-diene synthase but not of the 1,10-cyclase …
Ancient plant-like terpene biosynthesis in corals.
Burkhardt I, de Rond T, Chen PY, Moore BS. Burkhardt I, et al. Nat Chem Biol. 2022 Jun;18(6):664-669. doi: 10.1038/s41589-022-01026-2. Epub 2022 May 23. Nat Chem Biol. 2022. PMID: 35606558 Free PMC article.
Here, we challenge this long-standing paradigm by describing a monophyletic lineage of animal-encoded terpene cyclases (TCs) ubiquitous in octocorals. We characterized 15 TC enzymes from nine genera, several of which produce precursors of iconic coral-specific terpe …
Here, we challenge this long-standing paradigm by describing a monophyletic lineage of animal-encoded terpene cyclases (TCs) u …
8,383 results