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Page 1
Tiadenol-mediated induction of peroxisomal enzymes in cultured C3H/10T1/2CL8 cells and in chemically transformed C3H/10T1/2 MCA16 cells.
Berge RK, Lillehaug JR. Berge RK, et al. Int J Cancer. 1985 Oct 15;36(4):489-94. doi: 10.1002/ijc.2910360413. Int J Cancer. 1985. PMID: 2864317
A reproducible induction of cyanide-insensitive palmitoyl-CoA oxidative activity was observed 5 and 9 days after initiation of tiadenol treatment. Basal activity was 0.16 nmole/min/mg protein compared to 0.95 nmole/min/mg protein in cells treated with 18 microM tiadenol …
A reproducible induction of cyanide-insensitive palmitoyl-CoA oxidative activity was observed 5 and 9 days after initiation of tiadenol …
Antilipolytic activity of tiadenol-nicotinate in isolated fat cells: a comparison with its parent drugs.
Gaion RM, Murari L, Cima L, Valenti P, Da Re P. Gaion RM, et al. Drugs Exp Clin Res. 1985;11(6):407-11. Drugs Exp Clin Res. 1985. PMID: 3836137
Tiadenol-nicotinate is an ester in which two molecules of nicotinic acid are linked to one molecule of tiadenol. ...The possible therapeutic value of tiadenol-nicotinate is discussed....
Tiadenol-nicotinate is an ester in which two molecules of nicotinic acid are linked to one molecule of tiadenol. ...The possib …
Experimental studies on pharmacology, metabolism and toxicology with tiadenol-disulfoxide. Dissociation of lipid lowering effects and the induction of peroxisomal and microsomal drug-metabolizing enzymes.
Maffei Facino R, Carini M, Tofanetti O, Casciarri I, Longoni E. Maffei Facino R, et al. Arzneimittelforschung. 1987 Jun;37(6):682-91. Arzneimittelforschung. 1987. PMID: 3663266
The hypolipidemic activity of tiadenol-disulfoxide, the major metabolite of 1,10-bis(hydroxyethylthio)decane (tiadenol, Eulip) in man and in the rat was assessed in various experimental models versus the corresponding activity of tiadenol. ...Likewise, it is …
The hypolipidemic activity of tiadenol-disulfoxide, the major metabolite of 1,10-bis(hydroxyethylthio)decane (tiadenol, Eulip) …
Pharmacological studies on tiadenol in type IV patients. Evidence for a mechanism of action different from other lipid-lowering drugs.
Franceschini G, Poli A, Catapano AL, Gatti E, Sirtori M, Gianfranceschi G, Sirtori CR. Franceschini G, et al. Atherosclerosis. 1981 Nov-Dec;40(3-4):245-55. doi: 10.1016/0021-9150(81)90134-9. Atherosclerosis. 1981. PMID: 7332603
Tiadenol administration was remarkably effective in inhibiting fructose induced hypertriglyceridemia in diet responsive type IV patients; it was ineffective in patients with stable, diet refractory, hypertriglyceridemia. ...The reported observations are consistent with a d …
Tiadenol administration was remarkably effective in inhibiting fructose induced hypertriglyceridemia in diet responsive type IV patie …
The metabolic fate of 14C or 35S labelled tiadenol in rabbit after i.v. and oral administration.
Desager JP, Costermans J, Sclavons M, Harvengt C. Desager JP, et al. Eur J Drug Metab Pharmacokinet. 1986 Jul-Sep;11(3):225-32. doi: 10.1007/BF03189850. Eur J Drug Metab Pharmacokinet. 1986. PMID: 3816878
Tiadenol is a hypocholesterolemic drug that inhibits the early steps of cholesterol synthesis. ...No statistically significant differences in biotransformation were found between the two differently labelled tiadenol molecules....
Tiadenol is a hypocholesterolemic drug that inhibits the early steps of cholesterol synthesis. ...No statistically significant differ …
[Therapy of hypercholesterolemia and hypertriglyceridemia. Comparison of the lipid-lowering effect of simvastatin and tiadenol].
Serra T, Gavelli MS, Vitaliano E, Santini G, Catalano A, Rossi FG, Tozzi J, Caridis R, Guarini G. Serra T, et al. Clin Ter. 1990 Mar 15;132(5):307-13. Clin Ter. 1990. PMID: 2139833 Clinical Trial. Italian.
A comparative trial was carried out on the effect on lipid metabolism of two drugs which inhibit the enzyme systems involved in cholesterol synthesis: tiadenol and simvastatin. The trial was performed in 40 patients with non familial and non secondary hypercholesterolemia. …
A comparative trial was carried out on the effect on lipid metabolism of two drugs which inhibit the enzyme systems involved in cholesterol …
The effects of tiadenol, clofibrate and clofibride on bile composition in the rat.
Rozé C, Cuchet P, Souchard M, Vaille C, Debray C. Rozé C, et al. Eur J Pharmacol. 1977 May 1;43(1):57-64. doi: 10.1016/0014-2999(77)90160-1. Eur J Pharmacol. 1977. PMID: 862664
Biliary secretion was studied in normolipidemic rats after a 7 day treatment with the hypolipidemic drugs, tiadenol (bis-(hydroxyethylthio)-1,10-decane), clofibrate and clofibride (chloro-4-phenoxy-2-methyl-2-propionate of dimethylcarbamoyl-3-propyl). ...
Biliary secretion was studied in normolipidemic rats after a 7 day treatment with the hypolipidemic drugs, tiadenol (bis-(hydroxyethy …
Sex-related differences in the enhancing effects of perfluoro-octanoic acid on stearoyl-CoA desaturase and its influence on the acyl composition of phospholipid in rat liver. Comparison with clofibric acid and tiadenol.
Kawashima Y, Uy-Yu N, Kozuka H. Kawashima Y, et al. Biochem J. 1989 Nov 1;263(3):897-904. doi: 10.1042/bj2630897. Biochem J. 1989. PMID: 2574572 Free PMC article.
The effects of the peroxisome proliferators clofibric acid (p-chlorophenoxyisobutyric acid), tiadenol [2,2'-(decamethylenedithio)diethanol] and perfluoro-octanoic acid (PFOA) on hepatic stearoyl-CoA desaturation in male and female rats were compared. Treatment of male rats …
The effects of the peroxisome proliferators clofibric acid (p-chlorophenoxyisobutyric acid), tiadenol [2,2'-(decamethylenedithio)diet …
Effects of tiadenol and di-(2-ethylhexyl)phthalate on the metabolism of phosphatidylcholine and phosphatidylethanolamine in the liver of rats: comparison with clofibric acid.
Mizuguchi H, Kudo N, Ohya T, Kawashima Y. Mizuguchi H, et al. Biochem Pharmacol. 1999 Apr 15;57(8):869-76. doi: 10.1016/s0006-2952(98)00365-7. Biochem Pharmacol. 1999. PMID: 10086319
Treatment of rats with either tiadenol or DEHP increased the hepatic contents of PtdCho and PtdEtn, as was observed with clofibric acid treatment. The administration of tiadenol, DEHP, or clofibric acid slightly, but significantly, increased, in common, the activity …
Treatment of rats with either tiadenol or DEHP increased the hepatic contents of PtdCho and PtdEtn, as was observed with clofibric ac …
Carboxylic metabolites of tiadenol as "proximate" inducers of hepatic peroxisomal beta-oxidation activity.
Maffei Facino R, Carini M, Tofanetti O. Maffei Facino R, et al. Pharmacol Res Commun. 1988 Apr;20(4):265-76. doi: 10.1016/s0031-6989(88)80064-x. Pharmacol Res Commun. 1988. PMID: 3387457
Chronic exposure of rats to the hypolipidemic agent tiadenol causes a dramatic dose-dependent increase of peroxisomal beta-oxidation activity. ...No changes in the biodisposition of tiadenol (and tiadenol-disulfoxide) were found following chronic treatment fo …
Chronic exposure of rats to the hypolipidemic agent tiadenol causes a dramatic dose-dependent increase of peroxisomal beta-oxidation …
86 results