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Page 1
Showing results for tigogenin
Search for tigogenone instead (1 results)
Synthesis of tigogenin MeON-Neoglycosides and their antitumor activity.
Li GL, Xu HJ, Xu SH, Wang WW, Yu BY, Zhang J. Li GL, et al. Fitoterapia. 2018 Mar;125:33-40. doi: 10.1016/j.fitote.2017.12.014. Epub 2017 Dec 18. Fitoterapia. 2018. PMID: 29269236
The results revealed a sugar-dependent activity profile of their cytotoxicity, the glycoconjugation converted the non-active tigogenin to the most potential product Tg29 ((3R)-N-methoxyamino-tigogenin-beta-2-deoxy-d-galactoside) with IC(50) value of 2.7muM and 4.6mu …
The results revealed a sugar-dependent activity profile of their cytotoxicity, the glycoconjugation converted the non-active tigogenin …
Synthesis of Demissidine Analogues from Tigogenin via Imine Intermediates.
Wojtkielewicz A, Kiełczewska U, Baj A, Morzycki JW. Wojtkielewicz A, et al. Int J Mol Sci. 2021 Oct 8;22(19):10879. doi: 10.3390/ijms221910879. Int J Mol Sci. 2021. PMID: 34639219 Free PMC article.
A five-step transformation of a spiroketal side chain of tigogenin into an indolizidine system present in solanidane alkaloids such as demissidine and solanidine was elaborated. The key intermediate in the synthesis was spiroimine 3 readily obtained from tigogenin b …
A five-step transformation of a spiroketal side chain of tigogenin into an indolizidine system present in solanidane alkaloids such a …
(23R,231 S,25S)-231,26-Ep-oxy-23-ethyl-furost-20(22)-en-3β-ol.
Guerrero-Luna G, Hernández-Linares MG, Cárdenas García M, Bernès S. Guerrero-Luna G, et al. IUCrdata. 2023 Apr 21;8(Pt 4):x230344. doi: 10.1107/S2414314623003449. eCollection 2023 Apr. IUCrdata. 2023. PMID: 37151203 Free PMC article.
The title compound, C(29)H(46)O(3), is a steroid synthesized through a rearrangement of a sarsasapogenin derivative in acidic medium. The newly formed ring F is a tetra-hydro-2H-pyran heterocycle substituted by two methyl groups placed in equatorial positions. ...
The title compound, C(29)H(46)O(3), is a steroid synthesized through a rearrangement of a sarsasapogenin derivative in acidic medium. …
Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells.
Zhou H, Yang X, Wang N, Zhang Y, Cai G. Zhou H, et al. Mol Cell Endocrinol. 2007 May 30;270(1-2):17-22. doi: 10.1016/j.mce.2007.01.017. Epub 2007 Feb 12. Mol Cell Endocrinol. 2007. PMID: 17363141
We investigated the effect of tigogenin on adipocytic and osteoblastic differentiation in mouse bone marrow stromal cells (BMSCs). Tigogenin enhanced the proliferation of BMSCs significantly. Tigogenin treatment reduced the adipogenic induction of lipid accum …
We investigated the effect of tigogenin on adipocytic and osteoblastic differentiation in mouse bone marrow stromal cells (BMSCs). …
Synthesis and anti-tumour, immunomodulating activity of diosgenin and tigogenin conjugates.
Michalak O, Krzeczyński P, Cieślak M, Cmoch P, Cybulski M, Królewska-Golińska K, Kaźmierczak-Barańska J, Trzaskowski B, Ostrowska K. Michalak O, et al. J Steroid Biochem Mol Biol. 2020 Apr;198:105573. doi: 10.1016/j.jsbmb.2019.105573. Epub 2020 Feb 1. J Steroid Biochem Mol Biol. 2020. PMID: 32017993
A series of novel diosgenin (DSG) and tigogenin (TGG) derivatives with diosgenin or tigogenin steroid aglycons linked to levulinic and 3,4-dihydroxycinnamic acids, dipeptides and various amino acids by an ester bond at the C3-oxygen atom of the steroid skeleton has …
A series of novel diosgenin (DSG) and tigogenin (TGG) derivatives with diosgenin or tigogenin steroid aglycons linked to levul …
Concise synthesis of E/F ring spiroethers from tigogenin. Carbaanalogs of steroidal sapogenins and their biological activity.
Czajkowska-Szczykowska D, Olchowik-Grabarek E, Sękowski S, Żarkowski J, Morzycki JW. Czajkowska-Szczykowska D, et al. J Steroid Biochem Mol Biol. 2022 Nov;224:106174. doi: 10.1016/j.jsbmb.2022.106174. Epub 2022 Aug 30. J Steroid Biochem Mol Biol. 2022. PMID: 36055516 Free article.
A four-step synthesis of five- and six-membered E/F ring spiroethers from tigogenin has been developed. An efficient strategy that features bis-Grignard reaction of dinorcholanic lactone with appropriate bis(bromomagnesio)alkanes followed by acid-mediated spirocyclization …
A four-step synthesis of five- and six-membered E/F ring spiroethers from tigogenin has been developed. An efficient strategy that fe …
A Simple Four-Step Synthesis of the Potato Alkaloid Demissidine from the Common Sapogenin Tigogenin.
Baj A, Kaewnok N, Rivas-Loaiza JA, Szymańska M, Witkowski S, Wojtkielewicz A, Morzycki JW. Baj A, et al. Chemistry. 2023 Apr 6;29(20):e202203314. doi: 10.1002/chem.202203314. Epub 2023 Mar 13. Chemistry. 2023. PMID: 36720039
A simple synthesis method of solanidane alkaloids from common steroidal sapogenins was developed. Previously described multi-step transformations of tigogenin to demissidine (8-12 steps) were shortened to four steps only. ...Thus, the related solanidane alkaloids, 12beta-h …
A simple synthesis method of solanidane alkaloids from common steroidal sapogenins was developed. Previously described multi-step transforma …
(20S,2''S)-20-[4'-(3''-Hydroxy-2''-methyl-prop-yl)-3'-methylisoxazol-5-yl]-5β-preg-nan-3β,16β-diol.
Hernández Linares MG, Sandoval Ramírez J, Meza Reyes S, Montiel Smith S, Bernès S. Hernández Linares MG, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 28;65(Pt 12):o3265-6. doi: 10.1107/S1600536809050478. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21578960 Free PMC article.
The title steroidal compound, C(29)H(47)NO(4), was prepared in a one-pot reaction starting from a sarsasapogenin derivative of known configuration. The isoxazole heterocycle is oriented towards the alpha face of the steroid nucleus and, although fully functionalized on C a …
The title steroidal compound, C(29)H(47)NO(4), was prepared in a one-pot reaction starting from a sarsasapogenin derivative of known …
Efficient one-pot synthesis of tigogenin saponins and their antitumor activities.
Gu G, An L, Fang M, Guo Z. Gu G, et al. Carbohydr Res. 2014 Jan 13;383:21-6. doi: 10.1016/j.carres.2013.10.015. Epub 2013 Oct 30. Carbohydr Res. 2014. PMID: 24239606
An efficient synthesis of naturally occurring tigogenin triglycoside 1a and its three derivatives 1b-d bearing different carbohydrate moieties, as well as their antitumor activities, is described. ...
An efficient synthesis of naturally occurring tigogenin triglycoside 1a and its three derivatives 1b-d bearing different carbohydrate …
251 results