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Table representation of search results timeline featuring number of search results per year.
| Year | Number of Results |
|---|---|
| 1959 | 1 |
| 1962 | 2 |
| 1963 | 2 |
| 1964 | 2 |
| 1965 | 3 |
| 1966 | 2 |
| 1967 | 4 |
| 1968 | 7 |
| 1969 | 3 |
| 1970 | 4 |
| 1971 | 7 |
| 1972 | 5 |
| 1973 | 7 |
| 1974 | 3 |
| 1975 | 11 |
| 1976 | 8 |
| 1977 | 10 |
| 1978 | 6 |
| 1979 | 4 |
| 1980 | 7 |
| 1981 | 10 |
| 1982 | 8 |
| 1983 | 3 |
| 1984 | 16 |
| 1985 | 11 |
| 1986 | 10 |
| 1987 | 13 |
| 1988 | 21 |
| 1989 | 23 |
| 1990 | 12 |
| 1991 | 16 |
| 1992 | 18 |
| 1993 | 19 |
| 1994 | 16 |
| 1995 | 20 |
| 1996 | 21 |
| 1997 | 10 |
| 1998 | 16 |
| 1999 | 17 |
| 2000 | 13 |
| 2001 | 19 |
| 2002 | 15 |
| 2003 | 19 |
| 2004 | 17 |
| 2005 | 19 |
| 2006 | 22 |
| 2007 | 21 |
| 2008 | 14 |
| 2009 | 22 |
| 2010 | 18 |
| 2011 | 18 |
| 2012 | 28 |
| 2013 | 35 |
| 2014 | 24 |
| 2015 | 22 |
| 2016 | 26 |
| 2017 | 31 |
| 2018 | 26 |
| 2019 | 26 |
| 2020 | 33 |
| 2021 | 31 |
| 2022 | 23 |
| 2023 | 17 |
| 2024 | 6 |
Search Results
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Page 1
Calcium and Excitation-Contraction Coupling in the Heart.
Circ Res. 2017 Jul 7;121(2):181-195. doi: 10.1161/CIRCRESAHA.117.310230.
Circ Res. 2017.
PMID: 28684623
Free PMC article.
Review.
We consider 2 aspects: (1) structural coupling: the transporters are organized within the dyad, linking the transverse tubule and sarcoplasmic reticulum and ensuring close proximity of Ca entry to sites of release. (2) Functional coupling: where the fluxes across al …
We consider 2 aspects: (1) structural coupling: the transporters are organized within the dyad, linking the transverse tubule …
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes.
Circ Res. 2023 May 26;132(11):e188-e205. doi: 10.1161/CIRCRESAHA.122.321732. Epub 2023 May 4.
Circ Res. 2023.
PMID: 37139790
Free article.
BACKGROUND: Transverse tubules (t-tubules) form gradually in the developing heart, critically enabling maturation of cardiomyocyte Ca(2+) homeostasis. ...METHODS: We investigated the roles of BIN1, MTM1, and DNM2 in t-tubule formation in developing mou …
BACKGROUND: Transverse tubules (t-tubules) form gradually in the developing heart, critically enabling maturation of ca …
Advanced maturation of human cardiac tissue grown from pluripotent stem cells.
Nature. 2018 Apr;556(7700):239-243. doi: 10.1038/s41586-018-0016-3. Epub 2018 Apr 4.
Nature. 2018.
PMID: 29618819
Free PMC article.
Cardiac tissues generated from human induced pluripotent stem cells (iPSCs) can serve as platforms for patient-specific studies of physiology and disease(1-6). ...After only four weeks of culture, for all iPSC lines studied, such tissues displayed adult-like gene expressio …
Cardiac tissues generated from human induced pluripotent stem cells (iPSCs) can serve as platforms for patient-specific studies of ph …
Role of transverse tubules (T-tubules) in muscle glucose transport.
Adv Exp Med Biol. 1998;441:27-34. doi: 10.1007/978-1-4899-1928-1_3.
Adv Exp Med Biol. 1998.
PMID: 9781311
Review.
In a subsequent study using an entirely different technique, we labeled cell surface glucose transporters of rat muscle with a cell impermeant photolabel and demonstrated that a majority of the glucose transporters were translocated to T-tubules, not t …
In a subsequent study using an entirely different technique, we labeled cell surface glucose transporters of rat muscle with a …
Role of transverse tubules in insulin stimulated muscle glucose transport.
J Cell Biochem. 1993 May;52(1):1-7. doi: 10.1002/jcb.240520102.
J Cell Biochem. 1993.
PMID: 8320268
Review.
However, the observation that transverse tubule (T-tubule) membranes contain approximately five times more glucose transporter than sarcolemma raised a question as to where glucose transport occurs in muscle. ...Using immunocytochemical techniques we h …
However, the observation that transverse tubule (T-tubule) membranes contain approximately five times more glucose tran …
A fundamental evaluation of the electrical properties and function of cardiac transverse tubules.
Biochim Biophys Acta Mol Cell Res. 2020 Mar;1867(3):118502. doi: 10.1016/j.bbamcr.2019.06.016. Epub 2019 Jun 30.
Biochim Biophys Acta Mol Cell Res. 2020.
PMID: 31269418
Free article.
Review.
This work discusses active and passive electrical properties of transverse (T-)tubules in ventricular cardiomyocytes to understand the physiological roles of T-tubules. ...Higher heart rates correlate with higher T-tubular densities in mammalian ventricular c …
This work discusses active and passive electrical properties of transverse (T-)tubules in ventricular cardiomyocytes to unders …
A mouse model of Huntington's disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers.
J Gen Physiol. 2021 Apr 5;153(4):e202012637. doi: 10.1085/jgp.202012637.
J Gen Physiol. 2021.
PMID: 33683318
Free PMC article.
We recently demonstrated that skeletal muscle fibers from the R6/2 model mouse of HD have a decrease in specific membrane capacitance, suggesting a loss of transverse tubule (t-tubule) membrane in R6/2 muscle. ...We used live-cell imaging …
We recently demonstrated that skeletal muscle fibers from the R6/2 model mouse of HD have a decrease in specific membrane capacitance …
Biogenesis of transverse tubules in skeletal muscle in vitro.
Dev Biol. 1991 May;145(1):77-90. doi: 10.1016/0012-1606(91)90214-n.
Dev Biol. 1991.
PMID: 2019326
The transverse (T) tubules of skeletal muscle are membrane tubules that are continuous with the plasma membrane and penetrate the mature muscle fiber radially to carry surface membrane depolarization to the sites of excitation-contraction coupli …
The transverse (T) tubules of skeletal muscle are membrane tubules that are continuous with the plasma membrane …
Cardiac Transverse Tubules in Physiology and Heart Failure.
Annu Rev Physiol. 2022 Feb 10;84:229-255. doi: 10.1146/annurev-physiol-061121-040148. Epub 2021 Nov 15.
Annu Rev Physiol. 2022.
PMID: 34780259
Review.
In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma but also a network of membrane invaginations called transverse (t-) tubules. These structures carry the action potential deep into the cell interior, allowing efficient trigger …
In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma but also a network of membrane invaginations called tr …
Evolution of the cardiac dyad.
Philos Trans R Soc Lond B Biol Sci. 2022 Nov 21;377(1864):20210329. doi: 10.1098/rstb.2021.0329. Epub 2022 Oct 3.
Philos Trans R Soc Lond B Biol Sci. 2022.
PMID: 36189805
Free PMC article.
Review.
Cardiac dyads are the site of communication between the sarcoplasmic reticulum (SR) and infoldings of the sarcolemma called transverse-tubules (TT). During heart excitation-contraction coupling, Ca(2+)-influx through L-type Ca(2+) channels in the TT is amplified by …
Cardiac dyads are the site of communication between the sarcoplasmic reticulum (SR) and infoldings of the sarcolemma called transverse …
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