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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 5
1948 5
1949 5
1950 9
1951 25
1952 33
1953 52
1954 58
1955 47
1956 34
1957 29
1958 26
1959 38
1960 23
1961 23
1962 28
1963 79
1964 92
1965 67
1966 61
1967 84
1968 107
1969 119
1970 164
1971 129
1972 116
1973 123
1974 93
1975 132
1976 107
1977 131
1978 127
1979 131
1980 171
1981 171
1982 152
1983 202
1984 219
1985 192
1986 200
1987 210
1988 213
1989 228
1990 220
1991 204
1992 222
1993 232
1994 251
1995 292
1996 305
1997 351
1998 367
1999 413
2000 486
2001 551
2002 596
2003 679
2004 805
2005 889
2006 1058
2007 1059
2008 1164
2009 1244
2010 1330
2011 1340
2012 1329
2013 1330
2014 1290
2015 1277
2016 1132
2017 1187
2018 1268
2019 1290
2020 1308
2021 1325
2022 1173
2023 984
2024 491

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30,498 results

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Page 1
1,3,5-Triazine-azole Hybrids and their Anticancer Activity.
Guo H, Diao QP. Guo H, et al. Curr Top Med Chem. 2020;20(16):1481-1492. doi: 10.2174/1568026620666200310122741. Curr Top Med Chem. 2020. PMID: 32156236 Review.
1,3,5-Triazine and azole can interact with various therapeutic targets, and their derivatives possess promising in vitro and in vivo anticancer activity. ...Substantial efforts have been made to develop azole-containing 1,3,5-triazine hybrids as novel anticancer age …
1,3,5-Triazine and azole can interact with various therapeutic targets, and their derivatives possess promising in vitro and in vivo …
Synthesis and evaluation of anti-yellow fever virus activity of new 6-aryl-3-R-amino-1,2,4-triazin-5(4H)-ones.
Novodvorskyi Y, Lesyk R, Komarov I, Lega D, Zhuravel I, Moskalenko O, Sukhoveev V, Demchenko A. Novodvorskyi Y, et al. Eur J Med Chem. 2023 Feb 15;248:115117. doi: 10.1016/j.ejmech.2023.115117. Epub 2023 Jan 13. Eur J Med Chem. 2023. PMID: 36657300
In this regard, here we describe the synthesis of a series of new 6-aryl-3-R-amino-1,2,4-triazin-5(4H)-ones and evaluation of their in vitro inhibitory activity against yellow fever virus. ...
In this regard, here we describe the synthesis of a series of new 6-aryl-3-R-amino-1,2,4-triazin-5(4H)-ones and evaluation of their i …
5-arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists.
Schmitz WD, Brenner AB, Bronson JJ, Ditta JL, Griffin CR, Li YW, Lodge NJ, Molski TF, Olson RE, Zhuo X, Macor JE. Schmitz WD, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3579-83. doi: 10.1016/j.bmcl.2010.04.121. Epub 2010 May 17. Bioorg Med Chem Lett. 2010. PMID: 20483614
A series of 5-arylamino-1,2,4-triazin-6(1H)-ones was synthesized and evaluated as antagonists at the corticotropin releasing factor receptor. ...
A series of 5-arylamino-1,2,4-triazin-6(1H)-ones was synthesized and evaluated as antagonists at the corticotropin releasing factor r …
Functionalized Triazines and Tetrazines: Synthesis and Applications.
Mondal J, Sivaramakrishna A. Mondal J, et al. Top Curr Chem (Cham). 2022 Jun 23;380(5):34. doi: 10.1007/s41061-022-00385-7. Top Curr Chem (Cham). 2022. PMID: 35737142 Review.
The molecules possessing triazine and tetrazine moieties belong to a special class of heterocyclic compounds. ...Synthetic approaches contain linear, angular, and fused triazine and tetrazine heterocycles through a combinatorial method. ...
The molecules possessing triazine and tetrazine moieties belong to a special class of heterocyclic compounds. ...Synthetic approaches …
(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands.
Kamińska K, Ziemba J, Ner J, Schwed JS, Łażewska D, Więcek M, Karcz T, Olejarz A, Latacz G, Kuder K, Kottke T, Zygmunt M, Sapa J, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K. Kamińska K, et al. Eur J Med Chem. 2015 Oct 20;103:238-51. doi: 10.1016/j.ejmech.2015.08.014. Epub 2015 Aug 10. Eur J Med Chem. 2015. PMID: 26360048
A series of novel compounds in the group of 4-methylpiperazine-1,3,5-triazine-2-amines were designed and obtained. Considered structures were modified at the triazine 6-position by introduction of variously substituted arylethenyl moieties. ...Pharmacological studie …
A series of novel compounds in the group of 4-methylpiperazine-1,3,5-triazine-2-amines were designed and obtained. Considered structu …
Synthesis, beta -catenin Translocation Capability and ALP Activation Activity of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives.
Hou S, Xu H, Hu J, Hou J, Wang Y, Jin Z, Wan DCC, Hu C. Hou S, et al. Med Chem. 2018;14(1):67-73. doi: 10.2174/1573406413666171002121443. Med Chem. 2018. PMID: 28969571
The target compounds 3,6-diaryl-7H-thiazolo[3,2-b]-1,2,4-triazin-7-ones (3a-3c) were prepared by compound 2 with substituted alkyl chloride by Williamson reaction. As to 6-benzyl-3-aryl-7H-thiazolo[3,2- b]-1,2,4-triazin-7-one derivatives as the target compounds, the …
The target compounds 3,6-diaryl-7H-thiazolo[3,2-b]-1,2,4-triazin-7-ones (3a-3c) were prepared by compound 2 with substituted alkyl ch …
The Suppression of Columnar pi-Stacking in 3-Adamantyl-1-phenyl-1,4-dihydrobenzo[e][1,2,4]triazin-4-yl.
Constantinides CP, Berezin AA, Zissimou GA, Manoli M, Leitus GM, Koutentis PA. Constantinides CP, et al. Molecules. 2016 May 14;21(5):636. doi: 10.3390/molecules21050636. Molecules. 2016. PMID: 27187349 Free PMC article.
3-Adamantyl-1-phenyl-1,4-dihydrobenzo[e][1,2,4]triazin-4-yl (4) crystallizes as chains of radicals where the spin bearing benzotriazinyl moieties are isolated from each other. ...
3-Adamantyl-1-phenyl-1,4-dihydrobenzo[e][1,2,4]triazin-4-yl (4) crystallizes as chains of radicals where the spin bearing benzotriazi …
Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), design, synthesis and biological evaluation of novel PI3Kalpha selective inhibitors.
Wang Y, Liu Y, Ge T, Tang J, Wang S, Gao Z, Chen J, Xu J, Gong P, Zhao Y, Liu J, Hou Y. Wang Y, et al. Bioorg Chem. 2023 Jan;130:106211. doi: 10.1016/j.bioorg.2022.106211. Epub 2022 Oct 27. Bioorg Chem. 2023. PMID: 36343598
Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), three series of novel 1,3,5-triazine or pyrimidine derivatives containing semicarbazones have been designed and synthesized to obtain new potent and selective PI3Kal …
Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), three series of novel 1,3,5-t …
Synthesis and antifungal activity of 3-aryl-1,2,4-triazin-6-one derivatives.
Owen WJ, Sullenberger MT, Loso MR, Meyer KG, Slanec TJ. Owen WJ, et al. Pest Manag Sci. 2015 Jan;71(1):83-90. doi: 10.1002/ps.3765. Epub 2014 Apr 1. Pest Manag Sci. 2015. PMID: 25488592
A fungicide screening program identified 3-phenyl-1-(2,2,2-trifluoroethyl)-1,2,4-triazin-6(1H)-one (5) as a promising new starting point for further activity optimization. ...CONCLUSIONS: The present work demonstrated that the 3-phenyl-1,2,4-triazin-6-ones are a nov …
A fungicide screening program identified 3-phenyl-1-(2,2,2-trifluoroethyl)-1,2,4-triazin-6(1H)-one (5) as a promising new starting po …
1,3,5-Triazine: A versatile pharmacophore with diverse biological activities.
Singh S, Mandal MK, Masih A, Saha A, Ghosh SK, Bhat HR, Singh UP. Singh S, et al. Arch Pharm (Weinheim). 2021 Jun;354(6):e2000363. doi: 10.1002/ardp.202000363. Epub 2021 Mar 24. Arch Pharm (Weinheim). 2021. PMID: 33760298 Review.
1,3,5-Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to their effective biological activities, such as antibacterial, fungicidal, antimalarial, anticancer, antiviral, antimicrobial, anti-inflammatory, antiamoebic, and antitubercular …
1,3,5-Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to their effective biological activities …
30,498 results
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