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1987 2
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2000 7
2002 1
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51 results

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Page 1
Mildronate: cardioprotective action through carnitine-lowering effect.
Dambrova M, Liepinsh E, Kalvinsh I. Dambrova M, et al. Trends Cardiovasc Med. 2002 Aug;12(6):275-9. doi: 10.1016/s1050-1738(02)00175-5. Trends Cardiovasc Med. 2002. PMID: 12242052 Review.
Mildronate [3-(2,2,2-trimethylhydrazinium)propionate dihydrate] ameliorates cardiac function during ischemia by modulating myocardial energy metabolism. ...
Mildronate [3-(2,2,2-trimethylhydrazinium)propionate dihydrate] ameliorates cardiac function during ischemia by modulating myo …
Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.
Dambrova M, Makrecka-Kuka M, Vilskersts R, Makarova E, Kuka J, Liepinsh E. Dambrova M, et al. Pharmacol Res. 2016 Nov;113(Pt B):771-780. doi: 10.1016/j.phrs.2016.01.019. Epub 2016 Feb 2. Pharmacol Res. 2016. PMID: 26850121 Review.
Meldonium (mildronate; 3-(2,2,2-trimethylhydrazinium)propionate; THP; MET-88) is a clinically used cardioprotective drug, which mechanism of action is based on the regulation of energy metabolism pathways through l-carnitine lowering effect. l-Carnitine biosynthesis …
Meldonium (mildronate; 3-(2,2,2-trimethylhydrazinium)propionate; THP; MET-88) is a clinically used cardioprotective drug, whic …
Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2, 2-trimethylhydrazinium) propionate in mice: inhibition of carnitine transport in kidney.
Kuwajima M, Harashima H, Hayashi M, Ise S, Sei M, Lu Km, Kiwada H, Sugiyama Y, Shima K. Kuwajima M, et al. J Pharmacol Exp Ther. 1999 Apr;289(1):93-102. J Pharmacol Exp Ther. 1999. PMID: 10086992
The site of action of 3-(2,2,2-trimethylhydrazinium) propionate (THP), a new cardioprotective agent, was investigated in mice and rats. ...
The site of action of 3-(2,2,2-trimethylhydrazinium) propionate (THP), a new cardioprotective agent, was investigated in mice …
3-(2,2,2-Trimethylhydrazinium)propionate (THP)--a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties.
Simkhovich BZ, Shutenko ZV, Meirena DV, Khagi KB, Mezapuķe RJ, Molodchina TN, Kalviņs IJ, Lukevics E. Simkhovich BZ, et al. Biochem Pharmacol. 1988 Jan 15;37(2):195-202. doi: 10.1016/0006-2952(88)90717-4. Biochem Pharmacol. 1988. PMID: 3342076
A protein fraction containing gamma-butyrobetaine hydroxylase (sp.act. 1.54 mU/mg) was isolated from the rat liver by differential precipitation with ammonium sulphate. 3-(2,2,2-Trimethylhydrazinium)propionate (THP), a noncompetitive enzyme inhibitor, when administe …
A protein fraction containing gamma-butyrobetaine hydroxylase (sp.act. 1.54 mU/mg) was isolated from the rat liver by differential precipita …
Species specificity profiling of rat and human organic cation/carnitine transporter Slc22a5/SLC22A5 (Octn2/OCTN2).
Szabó K, Nagy Z, Juhász V, Zolnerciks JK, Csorba A, Tímár Z, Molnár É, Pádár P, Johnson W, Beéry E, Krajcsi P. Szabó K, et al. Drug Metab Pharmacokinet. 2017 Jun;32(3):165-171. doi: 10.1016/j.dmpk.2016.08.005. Epub 2016 Aug 26. Drug Metab Pharmacokinet. 2017. PMID: 28365301
The purpose of this study was to characterize the uptake of carnitine, the physiological substrate, and the uptake of 3-(2,2,2-trimethylhydrazinium)propionate, a consensus substrate by rat Octn2 and human OCTN2 transporters as well as to characterize drug-mediated i …
The purpose of this study was to characterize the uptake of carnitine, the physiological substrate, and the uptake of 3-(2,2,2-trimethylh …
Pharmacokinetics and biological fate of 3-(2,2, 2-trimethylhydrazinium)propionate dihydrate (MET-88), a novel cardioprotective agent, in rats.
Yoshisue K, Yamamoto Y, Yoshida K, Saeki M, Minami Y, Esumi Y, Kawaguchi Y. Yoshisue K, et al. Drug Metab Dispos. 2000 Jun;28(6):687-94. Drug Metab Dispos. 2000. PMID: 10820142
In this study, we examined the disposition, metabolism, and excretion of a novel cardioprotective agent, 3-(2,2, 2-trimethylhydrazinium)propionate dihydrate (MET-88), in rats. The disposition of MET-88 after oral and i.v. administration of 2, 20, and 60 mg/kg indica …
In this study, we examined the disposition, metabolism, and excretion of a novel cardioprotective agent, 3-(2,2, 2-trimethylhydrazinium …
Mildronate: an antiischemic drug for neurological indications.
Sjakste N, Gutcaits A, Kalvinsh I. Sjakste N, et al. CNS Drug Rev. 2005 Summer;11(2):151-68. doi: 10.1111/j.1527-3458.2005.tb00267.x. CNS Drug Rev. 2005. PMID: 16007237 Free PMC article. Review.
Mildronate (3-(2,2,2-trimethylhydrazinium)propionate; MET-88; meldonium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. ...
Mildronate (3-(2,2,2-trimethylhydrazinium)propionate; MET-88; meldonium, quaterine) is an antiischemic drug developed at the L …
Effect of 3-(2,2,2-trimethylhydrazinium) propionate, gamma-butyrobetaine hydroxylase inhibitor, on isoproterenol-induced mitochondrial dysfunction.
Hanaki Y, Sugiyama S, Ozawa T. Hanaki Y, et al. Res Commun Chem Pathol Pharmacol. 1989 Apr;64(1):157-60. Res Commun Chem Pathol Pharmacol. 1989. PMID: 2546223
The present study was designed to investigate whether or not reduction of carnitine content could protect isoproterenol (ISP)-induced myocardial injury using 3-(2,2,2-trimethylhydrazinium) propionate (TMHP), gamma-butyrobetaine hydroxylase inhibitor. ...
The present study was designed to investigate whether or not reduction of carnitine content could protect isoproterenol (ISP)-induced myocar …
[New opportunities for neuroprotective therapy of patients in the acute and early recovery period of ischemic stroke].
Tanashyan MM, Raskurazhev AA, Zaslavskaya KI, Kuznetsova PI, Merkulova IY. Tanashyan MM, et al. Ter Arkh. 2022 Aug 4;94(6):748-755. doi: 10.26442/00403660.2022.06.201743. Ter Arkh. 2022. PMID: 36286852 Clinical Trial. Russian.
AIM: To evaluate the efficacy and safety of Brainmax in comparison with ethylmethylhydroxypyridine succinate and trimethylhydrazinium propionate in patients with ischemic stroke in the acute and early recovery period. ...Patients were randomized to receive Brainmax, …
AIM: To evaluate the efficacy and safety of Brainmax in comparison with ethylmethylhydroxypyridine succinate and trimethylhydrazinium …
γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement.
Henry L, Leung IK, Claridge TD, Schofield CJ. Henry L, et al. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4975-8. doi: 10.1016/j.bmcl.2012.06.024. Epub 2012 Jun 16. Bioorg Med Chem Lett. 2012. PMID: 22765904
gamma-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II)-dependent oxygenase that catalyses the final step of L-carnitine biosynthesis in animals. BBOX catalyses the oxidation of 3-(2,2,2-trimethylhydrazinium)propionate (THP), a clinically used BBOX inh …
gamma-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II)-dependent oxygenase that catalyses the final step of L-carnitine biosy …
51 results