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Showing results for trimipramine p d
Your search for trimpramine-p-d retrieved no results
Trimipramine--an atypical neuroleptic?
Eikmeier G, Berger M, Lodemann E, Muszynski K, Kaumeier S, Gastpar M. Eikmeier G, et al. Int Clin Psychopharmacol. 1991 Winter;6(3):147-53. doi: 10.1097/00004850-199100630-00003. Int Clin Psychopharmacol. 1991. PMID: 1806621
Since both have the same affinity for the D2 receptor and since the affinity for this receptor correlates closely with the antipsychotic potency of a drug, an antipsychotic efficacy of trimipramine in acute schizophrenia could be expected. Therefore 28 schizophrenic patien …
Since both have the same affinity for the D2 receptor and since the affinity for this receptor correlates closely with the antipsychotic pot …
abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice.
Uhr M, Grauer MT. Uhr M, et al. J Psychiatr Res. 2003 May-Jun;37(3):179-85. doi: 10.1016/s0022-3956(03)00022-0. J Psychiatr Res. 2003. PMID: 12650738
One hour after s.c. injection of the drugs, concentrations of the two drugs and of the metabolite d-trimipramine in brain, spleen, kidney, liver and plasma were measured with HPLC. Significantly higher brain concentrations in knockout mice, showing that these drugs …
One hour after s.c. injection of the drugs, concentrations of the two drugs and of the metabolite d-trimipramine in brain, spl …
Cytochrome P450-mediated inhibition of venlafaxine metabolism by trimipramine.
Kowalewski C, Haen E, Hiemke C, Ridders F, Endres K, Gründer G, Paulzen M, Schoretsanitis G. Kowalewski C, et al. Int Clin Psychopharmacol. 2019 Sep;34(5):241-246. doi: 10.1097/YIC.0000000000000268. Int Clin Psychopharmacol. 2019. PMID: 31094902
For VEN, ODV and active moiety (sum of VEN + ODV) plasma concentrations and dose-adjusted concentrations as well as ODV/VEN ratios were compared between groups using the Mann-Whitney U test with a significance level of 0.05. RESULTS: Patients co-medicated with trimipramine …
For VEN, ODV and active moiety (sum of VEN + ODV) plasma concentrations and dose-adjusted concentrations as well as ODV/VEN ratios were comp …
Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patients.
Eap CB, Bender S, Gastpar M, Fischer W, Haarmann C, Powell K, Jonzier-Perey M, Cochard N, Baumann P. Eap CB, et al. Ther Drug Monit. 2000 Apr;22(2):209-14. doi: 10.1097/00007691-200004000-00012. Ther Drug Monit. 2000. PMID: 10774635
Steady state plasma concentrations of the (L)- and (D)-enantiomers of trimipramine (TRI), desmethyltrimipramine (DTRI), 2-hydroxytrimipramine (TRIOH) and 2-hydroxydesmethyl-trimipramine (DTRIOH) were measured in 27 patients receiving between 300 and 400 mg/da …
Steady state plasma concentrations of the (L)- and (D)-enantiomers of trimipramine (TRI), desmethyltrimipramine (DTRI), 2-hydr …
Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management.
Woolf AD, Erdman AR, Nelson LS, Caravati EM, Cobaugh DJ, Booze LL, Wax PM, Manoguerra AS, Scharman EJ, Olson KR, Chyka PA, Christianson G, Troutman WG. Woolf AD, et al. Clin Toxicol (Phila). 2007;45(3):203-33. doi: 10.1080/15563650701226192. Clin Toxicol (Phila). 2007. PMID: 17453872
For all TCAs except desipramine, nortriptyline, trimipramine, and protriptyline, this dose is >5 mg/kg. For despiramine it is >2.5 mg/kg; for nortriptyline it is >2.5 mg/kg; for trimipramine it is >2.5 mg/kg; and for protriptyline it is >1 mg/kg. ...A …
For all TCAs except desipramine, nortriptyline, trimipramine, and protriptyline, this dose is >5 mg/kg. For despiramine it is > …
Drug triggered pruritus, rash, papules, and blisters - is AGEP a clash of an altered sphingolipid-metabolism and lysosomotropism of drugs accumulating in the skin?
Blaess M, Kaiser L, Sommerfeld O, Csuk R, Deigner HP. Blaess M, et al. Lipids Health Dis. 2021 Nov 8;20(1):156. doi: 10.1186/s12944-021-01552-3. Lipids Health Dis. 2021. PMID: 34743684 Free PMC article. Review.
To date, the etiology is not well understood and individual susceptibility still remains unknown. Amiodarone, chlorpromazine, amitriptyline, and trimipramine are classified lysosomotropic as well as photosensitizing, however, they fail to trigger rash and pruritic papules …
To date, the etiology is not well understood and individual susceptibility still remains unknown. Amiodarone, chlorpromazine, amitriptyline, …
Repeated trimipramine induces dopamine D2/D3 and alpha1-adrenergic up-regulation.
Maj J, Rogóz Z, Skuza G, Margas W. Maj J, et al. J Neural Transm (Vienna). 1998;105(2-3):329-42. doi: 10.1007/s007020050062. J Neural Transm (Vienna). 1998. PMID: 9660111
Trimipramine (TRI), which shows a clinical antidepressant activity, is chemically related to imipramine but does not inhibit the reuptake of noradrenaline and 5-hydroxytryptamine, nor does it induce beta-adrenergic down-regulation. ...TRI given repeatedly to rats increases …
Trimipramine (TRI), which shows a clinical antidepressant activity, is chemically related to imipramine but does not inhibit the reup …
Electrocardiographic abnormalities during recovery from ultra-short opiate detoxification.
Allhoff T, Renzing-Köhler K, Kienbaum P, Sack S, Scherbaum N. Allhoff T, et al. Addict Biol. 1999 Jul;4(3):337-44. doi: 10.1080/13556219971551. Addict Biol. 1999. PMID: 20575801
Compared to the initial values, heart rate was significantly lowered in the first two tracings after detoxification (median values 60.0/min. vs. 52,5/min; p=0.0006). The lowest heart rate measured after detoxification was 44/min. ...Serum potassium was significantly lowere …
Compared to the initial values, heart rate was significantly lowered in the first two tracings after detoxification (median values 60.0/min. …
In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned.
Lipponen A, Natunen T, Hujo M, Ciszek R, Hämäläinen E, Tohka J, Hiltunen M, Paananen J, Poulsen D, Kansanen E, Ekolle Ndode-Ekane X, Levonen AL, Pitkänen A. Lipponen A, et al. Int J Mol Sci. 2019 Oct 29;20(21):5395. doi: 10.3390/ijms20215395. Int J Mol Sci. 2019. PMID: 31671916 Free PMC article.

Based on (a) therapeutic time window in silico, (b) blood-brain barrier penetration and water solubility, (c) anti-inflammatory and neuroprotective effects in vitro (p < 0.05) and (d) target engagement of Nrf2 target genes (p < 0.05), desmethylclomipram

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Based on (a) therapeutic time window in silico, (b) blood-brain barrier penetration and water solubility, (c) anti-inflammatory and neuropro …
Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG.
Murck H, Held K, Ziegenbein M, Künzel H, Holsboer F, Steiger A. Murck H, et al. Psychoneuroendocrinology. 2004 Oct;29(9):1205-11. doi: 10.1016/j.psyneuen.2004.02.006. Psychoneuroendocrinology. 2004. PMID: 15219645 Clinical Trial.

METHODS: Galanin was administered to 10 patients with depression, who were on a stable dose of trimipramine. A placebo controlled double blind randomized design was used. ...MANOVA revealed a significant change in sleep-EEG parameters (p < 0.05), mainly due to an

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METHODS: Galanin was administered to 10 patients with depression, who were on a stable dose of trimipramine. A placebo controlled dou …