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Steady-state nevirapine, lamivudine and stavudine levels in Malawian HIV-infected children on antiretroviral therapy using split Triomune 30 tablets.
Poerksen G, Pollock L, Moons P, Chesshyre E, Burger D, Khoo S, Molyneux E. Poerksen G, et al. Antivir Ther. 2010;15(3):343-50. doi: 10.3851/IMP1544. Antivir Ther. 2010. PMID: 20516554 Free PMC article.
In 2006, the national paediatric ART regime was changed from Triomune 40 (T40) to Triomune 30 (T30). METHODS: This was a cross-sectional study conducted at the paediatric ART clinic in Blantyre (Malawi) from September 2006 to July 2007. ...
In 2006, the national paediatric ART regime was changed from Triomune 40 (T40) to Triomune 30 (T30). METHODS: This was a cross …
Pharmacokinetics of generic and trade formulations of lamivudine, stavudine and nevirapine in HIV-infected Malawian children.
Corbett AH, Hosseinipour MC, Nyirenda J, Kanyama C, Rezk NL, Mkupani P, Sichali D, Tien H, Kashuba AD, Mwansambo C, Weigel R, Kazembe P. Corbett AH, et al. Antivir Ther. 2010;15(1):83-90. doi: 10.3851/IMP1488. Antivir Ther. 2010. PMID: 20167994 Free PMC article. Clinical Trial.
BACKGROUND: The aim of this study was to evaluate the pharmacokinetics of lamivudine (3TC), stavudine (d4T) and nevirapine (NVP) in HIV-infected Malawian children receiving quartered tablet multiples of Triomune 40 (generic tablet [GT]) compared with individual gene …
BACKGROUND: The aim of this study was to evaluate the pharmacokinetics of lamivudine (3TC), stavudine (d4T) and nevirapine (NVP) in HIV-infe …
Steady-state pharmacokinetic comparison of generic and branded formulations of stavudine, lamivudine and nevirapine in HIV-infected Ugandan adults.
Byakika-Kibwika P, Lamorde M, Kalemeera F, D'Avolio A, Mauro S, Di Perri G, Ryan M, Mayanja-Kizza H, Khoo S, Back D, Boffito M, Merry C. Byakika-Kibwika P, et al. J Antimicrob Chemother. 2008 Nov;62(5):1113-7. doi: 10.1093/jac/dkn290. Epub 2008 Jul 18. J Antimicrob Chemother. 2008. PMID: 18641036 Free PMC article. Clinical Trial.
BACKGROUND: We aimed to compare the steady-state pharmacokinetic parameters and tolerability of Triomune 40 (stavudine 40 mg, lamivudine 150 mg and nevirapine 200 mg) and branded formulations of these drugs in HIV-infected Ugandans. ...
BACKGROUND: We aimed to compare the steady-state pharmacokinetic parameters and tolerability of Triomune 40 (stavudine 40 mg, …
Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults.
Byakika-Tusiime J, Chinn LW, Oyugi JH, Obua C, Bangsberg DR, Kroetz DL. Byakika-Tusiime J, et al. PLoS One. 2008;3(12):e3981. doi: 10.1371/journal.pone.0003981. Epub 2008 Dec 19. PLoS One. 2008. PMID: 19096711 Free PMC article. Clinical Trial.
METHODOLOGY/PRINCIPAL FINDINGS: An open-label, randomized, crossover study was carried out in 18 HIV-infected Ugandan subjects stabilized on Triomune-40. Subjects received lamivudine (150 mg), stavudine (40 mg), and nevirapine (200 mg) in either the generic or brand …
METHODOLOGY/PRINCIPAL FINDINGS: An open-label, randomized, crossover study was carried out in 18 HIV-infected Ugandan subjects stabilized on …
Pharmacokinetic comparison of generic and trade formulations of lamivudine, stavudine and nevirapine in HIV-infected Malawian adults.
Hosseinipour MC, Corbett AH, Kanyama C, Mshali I, Phakati S, Rezk NL, van der Horst C, Kashuba AD. Hosseinipour MC, et al. AIDS. 2007 Jan 2;21(1):59-64. doi: 10.1097/QAD.0b013e3280117ca0. AIDS. 2007. PMID: 17148968 Clinical Trial.
METHODS: This randomized, open label, cross-over study comprised of six men and six women currently receiving Triomune-40 TM who were randomized to the generic or trade formulation of stavudine (40 mg twice daily), lamivudine (150 mg twice daily) and nevirapine (200 …
METHODS: This randomized, open label, cross-over study comprised of six men and six women currently receiving Triomune-40 TM w …
Nevirapine concentrations in HIV-infected children treated with divided fixed-dose combination antiretroviral tablets in Malawi and Zambia.
Ellis JC, L'homme RF, Ewings FM, Mulenga V, Bell F, Chileshe R, Molyneux E, Abernethy J, van Oosterhout JJ, Chintu C, Walker AS, Gibb DM, Burger DM. Ellis JC, et al. Antivir Ther. 2007;12(2):253-60. Antivir Ther. 2007. PMID: 17503667
CONCLUSIONS: Currently available adult fixed-dose combination tablets are not well suited to children, particularly at younger ages: Triomune 30 is preferable to Triomune 40 because of the higher dose of nevirapine relative to stavudine. ...
CONCLUSIONS: Currently available adult fixed-dose combination tablets are not well suited to children, particularly at younger ages: Triomun …