D-serine-induced nephrotoxicity: possible interaction with tyrosine metabolism.
Williams RE, Lock EA.
Williams RE, et al.
Toxicology. 2004 Sep 1;201(1-3):231-8. doi: 10.1016/j.tox.2004.05.001.
Toxicology. 2004.
PMID: 15297036
NTBC alone caused a marked increase in the excretion of 4-hydroxyphenylpyruvate (HPPA) and 4-hydroxyphenyllactate (HPLA); however, HPPA and HPLA excretion was minimal following NTBC + D-serine. Instead marked tyrosinuria was observed suggesting that D-serine-induced renal …
NTBC alone caused a marked increase in the excretion of 4-hydroxyphenylpyruvate (HPPA) and 4-hydroxyphenyllactate (HPLA); however, HPPA and …