New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix.
Murakami N, Ye Y, Kawanishi M, Aoki S, Kudo N, Yoshida M, Nakayama EE, Shioda T, Kobayashi M.
Murakami N, et al.
Bioorg Med Chem Lett. 2002 Oct 21;12(20):2807-10. doi: 10.1016/s0960-894x(02)00624-8.
Bioorg Med Chem Lett. 2002.
PMID: 12270151
Bioassay-guided separation by use of the fission yeast expressing NES of Rev, a HIV-1 viral regulatory protein, resulted in isolation of valtrate (1) as a new Rev-transport inhibitor from the nucleus to cytoplasm from Valerianae Radix. Valtrate (1) also inhibited th …
Bioassay-guided separation by use of the fission yeast expressing NES of Rev, a HIV-1 viral regulatory protein, resulted in isolation of val …