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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia); Netherlands Brain Bank (NBB); Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L,… See abstract for full author list ➔ van der Lee SJ, et al. Among authors: van eijk kr, van den akker e, van schoor nm, van berckel bnm, van der flier wm, van gerpen ja. Acta Neuropathol. 2019 Aug;138(2):237-250. doi: 10.1007/s00401-019-02026-8. Epub 2019 May 27. Acta Neuropathol. 2019. PMID: 31131421 Free PMC article.
Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET.
Tolboom N, Yaqub M, van der Flier WM, Boellaard R, Luurtsema G, Windhorst AD, Barkhof F, Scheltens P, Lammertsma AA, van Berckel BN. Tolboom N, et al. J Nucl Med. 2009 Feb;50(2):191-7. doi: 10.2967/jnumed.108.056499. Epub 2009 Jan 21. J Nucl Med. 2009. PMID: 19164243 Free article.
Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease.
Tolboom N, Yaqub M, Boellaard R, Luurtsema G, Windhorst AD, Scheltens P, Lammertsma AA, van Berckel BN. Tolboom N, et al. Eur J Nucl Med Mol Imaging. 2009 Oct;36(10):1629-38. doi: 10.1007/s00259-009-1129-6. Epub 2009 Apr 22. Eur J Nucl Med Mol Imaging. 2009. PMID: 19384547 Free PMC article.
Simplified parametric methods for [18F]FDDNP studies.
Yaqub M, Tolboom N, van Berckel BN, Scheltens P, Lammertsma AA, Boellaard R. Yaqub M, et al. Neuroimage. 2010 Jan 1;49(1):433-41. doi: 10.1016/j.neuroimage.2009.07.046. Epub 2009 Jul 28. Neuroimage. 2010. PMID: 19643186
Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding.
Tolboom N, van der Flier WM, Yaqub M, Boellaard R, Verwey NA, Blankenstein MA, Windhorst AD, Scheltens P, Lammertsma AA, van Berckel BN. Tolboom N, et al. J Nucl Med. 2009 Sep;50(9):1464-70. doi: 10.2967/jnumed.109.064360. Epub 2009 Aug 18. J Nucl Med. 2009. PMID: 19690025 Free article.
270 results