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Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis.
Wouters K, van Gorp PJ, Bieghs V, Gijbels MJ, Duimel H, Lütjohann D, Kerksiek A, van Kruchten R, Maeda N, Staels B, van Bilsen M, Shiri-Sverdlov R, Hofker MH. Wouters K, et al. Among authors: van gorp pj, van bilsen m, van kruchten r. Hepatology. 2008 Aug;48(2):474-86. doi: 10.1002/hep.22363. Hepatology. 2008. PMID: 18666236
Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism.
Gilde AJ, van der Lee KA, Willemsen PH, Chinetti G, van der Leij FR, van der Vusse GJ, Staels B, van Bilsen M. Gilde AJ, et al. Among authors: van der lee ka, van bilsen m, van der leij fr, van der vusse gj. Circ Res. 2003 Mar 21;92(5):518-24. doi: 10.1161/01.RES.0000060700.55247.7C. Epub 2003 Feb 6. Circ Res. 2003. PMID: 12600885
Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice.
Bieghs V, Wouters K, van Gorp PJ, Gijbels MJ, de Winther MP, Binder CJ, Lütjohann D, Febbraio M, Moore KJ, van Bilsen M, Hofker MH, Shiri-Sverdlov R. Bieghs V, et al. Among authors: van gorp pj, van bilsen m. Gastroenterology. 2010 Jun;138(7):2477-86, 2486.e1-3. doi: 10.1053/j.gastro.2010.02.051. Epub 2010 Mar 2. Gastroenterology. 2010. PMID: 20206177 Free PMC article.
LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease.
Bieghs V, Van Gorp PJ, Wouters K, Hendrikx T, Gijbels MJ, van Bilsen M, Bakker J, Binder CJ, Lütjohann D, Staels B, Hofker MH, Shiri-Sverdlov R. Bieghs V, et al. Among authors: van gorp pj, van bilsen m. PLoS One. 2012;7(1):e30668. doi: 10.1371/journal.pone.0030668. Epub 2012 Jan 25. PLoS One. 2012. PMID: 22295101 Free PMC article.
Macrophage microRNA-155 promotes cardiac hypertrophy and failure.
Heymans S, Corsten MF, Verhesen W, Carai P, van Leeuwen RE, Custers K, Peters T, Hazebroek M, Stöger L, Wijnands E, Janssen BJ, Creemers EE, Pinto YM, Grimm D, Schürmann N, Vigorito E, Thum T, Stassen F, Yin X, Mayr M, de Windt LJ, Lutgens E, Wouters K, de Winther MP, Zacchigna S, Giacca M, van Bilsen M, Papageorgiou AP, Schroen B. Heymans S, et al. Among authors: van leeuwen re, van bilsen m. Circulation. 2013 Sep 24;128(13):1420-32. doi: 10.1161/CIRCULATIONAHA.112.001357. Epub 2013 Aug 16. Circulation. 2013. PMID: 23956210
Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARalpha and PPARdelta.
Smeets PJ, Teunissen BE, Planavila A, de Vogel-van den Bosch H, Willemsen PH, van der Vusse GJ, van Bilsen M. Smeets PJ, et al. Among authors: van bilsen m, van der vusse gj. J Biol Chem. 2008 Oct 24;283(43):29109-18. doi: 10.1074/jbc.M802143200. Epub 2008 Aug 12. J Biol Chem. 2008. PMID: 18701451 Free PMC article.
142 results