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Skeletal muscle in healthy humans exhibits a day-night rhythm in lipid metabolism.
Held NM, Wefers J, van Weeghel M, Daemen S, Hansen J, Vaz FM, van Moorsel D, Hesselink MKC, Houtkooper RH, Schrauwen P. Held NM, et al. Among authors: van weeghel m, van moorsel d. Mol Metab. 2020 Jul;37:100989. doi: 10.1016/j.molmet.2020.100989. Epub 2020 Apr 6. Mol Metab. 2020. PMID: 32272236 Free PMC article.
Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.
van Weeghel M, Abdurrachim D, Nederlof R, Argmann CA, Houtkooper RH, Hagen J, Nabben M, Denis S, Ciapaite J, Kolwicz SC Jr, Lopaschuk GD, Auwerx J, Nicolay K, Des Rosiers C, Wanders RJ, Zuurbier CJ, Prompers JJ, Houten SM. van Weeghel M, et al. Cardiovasc Res. 2018 Aug 1;114(10):1324-1334. doi: 10.1093/cvr/cvy089. Cardiovasc Res. 2018. PMID: 29635338
Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation.
Held NM, Kuipers EN, van Weeghel M, van Klinken JB, Denis SW, Lombès M, Wanders RJ, Vaz FM, Rensen PCN, Verhoeven AJ, Boon MR, Houtkooper RH. Held NM, et al. Among authors: van weeghel m, van klinken jb. Sci Rep. 2018 Jun 22;8(1):9562. doi: 10.1038/s41598-018-27875-3. Sci Rep. 2018. PMID: 29934543 Free PMC article.
Barth syndrome cells display widespread remodeling of mitochondrial complexes without affecting metabolic flux distribution.
Chatzispyrou IA, Guerrero-Castillo S, Held NM, Ruiter JPN, Denis SW, IJlst L, Wanders RJ, van Weeghel M, Ferdinandusse S, Vaz FM, Brandt U, Houtkooper RH. Chatzispyrou IA, et al. Among authors: van weeghel m. Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3650-3658. doi: 10.1016/j.bbadis.2018.08.041. Epub 2018 Sep 1. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 30251684 Free article.
A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.
Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wüst RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'neill LA, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J. Baardman J, et al. Among authors: van weeghel m, van den bossche j, van der velden s. Cell Rep. 2018 Nov 20;25(8):2044-2052.e5. doi: 10.1016/j.celrep.2018.10.092. Cell Rep. 2018. PMID: 30463003 Free article.
Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism Caenorhabditis elegans.
Witting M, Hastings J, Rodriguez N, Joshi CJ, Hattwell JPN, Ebert PR, van Weeghel M, Gao AW, Wakelam MJO, Houtkooper RH, Mains A, Le Novère N, Sadykoff S, Schroeder F, Lewis NE, Schirra HJ, Kaleta C, Casanueva O. Witting M, et al. Among authors: van weeghel m. Front Mol Biosci. 2018 Nov 14;5:96. doi: 10.3389/fmolb.2018.00096. eCollection 2018. Front Mol Biosci. 2018. PMID: 30488036 Free PMC article.
Right ventricular pressure overload alters cardiac lipid composition.
Koop AMC, Hagdorn QAJ, Bossers GPL, van Leusden T, Gerding A, van Weeghel M, Vaz FM, Koonen DPY, Silljé HHW, Berger RMF, Bartelds B. Koop AMC, et al. Among authors: van weeghel m, van leusden t. Int J Cardiol. 2019 Jul 15;287:96-105. doi: 10.1016/j.ijcard.2019.04.004. Epub 2019 Apr 8. Int J Cardiol. 2019. PMID: 31003793
Mutations in PCYT2 disrupt etherlipid biosynthesis and cause a complex hereditary spastic paraplegia.
Vaz FM, McDermott JH, Alders M, Wortmann SB, Kölker S, Pras-Raves ML, Vervaart MAT, van Lenthe H, Luyf ACM, Elfrink HL, Metcalfe K, Cuvertino S, Clayton PE, Yarwood R, Lowe MP, Lovell S, Rogers RC; Deciphering Developmental Disorders Study; van Kampen AHC, Ruiter JPN, Wanders RJA, Ferdinandusse S, van Weeghel M, Engelen M, Banka S. Vaz FM, et al. Among authors: van weeghel m, van lenthe h, van kampen ahc. Brain. 2019 Nov 1;142(11):3382-3397. doi: 10.1093/brain/awz291. Brain. 2019. PMID: 31637422 Free PMC article.
Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism.
Lezzerini M, Penzo M, O'Donohue MF, Marques Dos Santos Vieira C, Saby M, Elfrink HL, Diets IJ, Hesse AM, Couté Y, Gastou M, Nin-Velez A, Nikkels PGJ, Olson AN, Zonneveld-Huijssoon E, Jongmans MCJ, Zhang G, van Weeghel M, Houtkooper RH, Wlodarski MW, Kuiper RP, Bierings MB, van der Werff Ten Bosch J, Leblanc T, Montanaro L, Dinman JD, Da Costa L, Gleizes PE, MacInnes AW. Lezzerini M, et al. Among authors: van weeghel m, van der werff ten bosch j. Nucleic Acids Res. 2020 Jan 24;48(2):770-787. doi: 10.1093/nar/gkz1042. Nucleic Acids Res. 2020. PMID: 31799629 Free PMC article.
93 results