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Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma.
Lokhorst HM, Plesner T, Laubach JP, Nahi H, Gimsing P, Hansson M, Minnema MC, Lassen U, Krejcik J, Palumbo A, van de Donk NW, Ahmadi T, Khan I, Uhlar CM, Wang J, Sasser AK, Losic N, Lisby S, Basse L, Brun N, Richardson PG. Lokhorst HM, et al. Among authors: van de donk nw. N Engl J Med. 2015 Sep 24;373(13):1207-19. doi: 10.1056/NEJMoa1506348. Epub 2015 Aug 26. N Engl J Med. 2015. PMID: 26308596 Free article. Clinical Trial.
Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma.
Krejcik J, Casneuf T, Nijhof IS, Verbist B, Bald J, Plesner T, Syed K, Liu K, van de Donk NW, Weiss BM, Ahmadi T, Lokhorst HM, Mutis T, Sasser AK. Krejcik J, et al. Among authors: van de donk nw. Blood. 2016 Jul 21;128(3):384-94. doi: 10.1182/blood-2015-12-687749. Epub 2016 May 24. Blood. 2016. PMID: 27222480 Free PMC article. Clinical Trial.
CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma.
Nijhof IS, Casneuf T, van Velzen J, van Kessel B, Axel AE, Syed K, Groen RW, van Duin M, Sonneveld P, Minnema MC, Zweegman S, Chiu C, Bloem AC, Mutis T, Lokhorst HM, Sasser AK, van de Donk NW. Nijhof IS, et al. Among authors: van velzen j, van de donk nw, van duin m, van kessel b. Blood. 2016 Aug 18;128(7):959-70. doi: 10.1182/blood-2016-03-703439. Epub 2016 Jun 15. Blood. 2016. PMID: 27307294 Free article. Clinical Trial.
Response to: Interference of daratumumab on the serum protein electrophoresis.
McCudden C, Axel AE, Slaets D, Dejoie T, Clemens P, Frans S, Bald J, Plesner T, Jacobs JF, van de Donk NW, Moreau P, Schecter JM, Ahmadi T, Sasser AK. McCudden C, et al. Among authors: van de donk nw. Clin Chem Lab Med. 2017 Feb 1;55(2):e29-e30. doi: 10.1515/cclm-2016-1026. Clin Chem Lab Med. 2017. PMID: 27930366 Free article. No abstract available.
Could daratumumab be used to treat severe allergy?
Blankestijn MA, van de Donk NWCJ, Sasser K, Knulst AC, Otten HG. Blankestijn MA, et al. J Allergy Clin Immunol. 2017 May;139(5):1677-1678.e3. doi: 10.1016/j.jaci.2016.12.955. Epub 2017 Jan 19. J Allergy Clin Immunol. 2017. PMID: 28109726 No abstract available.
Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab.
Krejcik J, Frerichs KA, Nijhof IS, van Kessel B, van Velzen JF, Bloem AC, Broekmans MEC, Zweegman S, van Meerloo J, Musters RJP, Poddighe PJ, Groen RWJ, Chiu C, Plesner T, Lokhorst HM, Sasser AK, Mutis T, van de Donk NWCJ. Krejcik J, et al. Clin Cancer Res. 2017 Dec 15;23(24):7498-7511. doi: 10.1158/1078-0432.CCR-17-2027. Epub 2017 Oct 12. Clin Cancer Res. 2017. PMID: 29025767 Free PMC article. Clinical Trial.
204 results