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126 results

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The effect of mirabegron, a potent and selective β3-adrenoceptor agonist, on the pharmacokinetics of CYP2D6 substrates desipramine and metoprolol.
Krauwinkel W, Dickinson J, Schaddelee M, Meijer J, Tretter R, van de Wetering J, Strabach G, van Gelderen M. Krauwinkel W, et al. Among authors: van gelderen m, van de wetering j. Eur J Drug Metab Pharmacokinet. 2014 Mar;39(1):43-52. doi: 10.1007/s13318-013-0133-1. Epub 2013 Jun 1. Eur J Drug Metab Pharmacokinet. 2014. PMID: 23728524 Clinical Trial.
Preclinical and Clinical Pharmacokinetics and Bioavailability in Healthy Volunteers of a Novel Formulation of the Selective P2X3 Receptor Antagonist Eliapixant.
Francke K, Chattopadhyay N, Klein S, Rottmann A, Krickau D, van de Wetering J, Friedrich C. Francke K, et al. Among authors: van de wetering j. Eur J Drug Metab Pharmacokinet. 2023 Jan;48(1):75-87. doi: 10.1007/s13318-022-00805-5. Epub 2022 Dec 5. Eur J Drug Metab Pharmacokinet. 2023. PMID: 36469250 Clinical Trial.
First-in-human study with ACT-1014-6470, a novel oral complement factor 5a receptor 1 (C5aR1) antagonist, supported by pharmacokinetic predictions from animals to patients.
Ort M, Dingemanse J, Hsin CH, Richard M, Huehn E, Sabattini G, van de Wetering J, Kornberger R, van den Anker J, Kaufmann P. Ort M, et al. Among authors: van de wetering j, van den anker j. Basic Clin Pharmacol Toxicol. 2022 Aug;131(2):114-128. doi: 10.1111/bcpt.13756. Epub 2022 Jun 8. Basic Clin Pharmacol Toxicol. 2022. PMID: 35596117 Free article. Clinical Trial.
Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy subjects.
Cohen-Barak O, Wildeman J, van de Wetering J, Hettinga J, Schuilenga-Hut P, Gross A, Clark S, Bassan M, Gilgun-Sherki Y, Mendzelevski B, Spiegelstein O. Cohen-Barak O, et al. Among authors: van de wetering j. J Clin Pharmacol. 2015 May;55(5):573-83. doi: 10.1002/jcph.450. Epub 2015 Jan 12. J Clin Pharmacol. 2015. PMID: 25524052 Free PMC article. Clinical Trial.
Randomised clinical trial: anti-viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV.
Bergmann JF, de Bruijne J, Hotho DM, de Knegt RJ, Boonstra A, Weegink CJ, van Vliet AA, van de Wetering J, Fletcher SP, Bauman LA, Rahimy M, Appleman JR, Freddo JL, Janssen HL, Reesink HW. Bergmann JF, et al. Among authors: van vliet aa, van de wetering j, de knegt rj, de bruijne j. Aliment Pharmacol Ther. 2011 Aug;34(4):443-53. doi: 10.1111/j.1365-2036.2011.04745.x. Epub 2011 Jun 26. Aliment Pharmacol Ther. 2011. PMID: 21707679 Free article. Clinical Trial.
Clinical pharmacokinetics of leriglitazone and a translational approach using PBPK modeling to guide the selection of the starting dose in children.
Traver E, Rodríguez-Pascau L, Meya U, Pina G, Pascual S, Poli S, Eckland D, van de Wetering J, Ke A, Lindauer A, Martinell M, Pizcueta P. Traver E, et al. Among authors: van de wetering j. CPT Pharmacometrics Syst Pharmacol. 2024 Mar 29. doi: 10.1002/psp4.13132. Online ahead of print. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38549500 Free article.
From data to a validated score-based LR system: A practitioner's guide.
Leegwater AJ, Vergeer P, Alberink I, van der Ham LV, van de Wetering J, El Harchaoui R, Bosma W, Ypma RJF, Sjerps MJ. Leegwater AJ, et al. Among authors: van de wetering j. Forensic Sci Int. 2024 Apr;357:111994. doi: 10.1016/j.forsciint.2024.111994. Epub 2024 Mar 18. Forensic Sci Int. 2024. PMID: 38522325 Free article.
126 results