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The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane.
Elstak ED, Neeft M, Nehme NT, Voortman J, Cheung M, Goodarzifard M, Gerritsen HC, van Bergen En Henegouwen PM, Callebaut I, de Saint Basile G, van der Sluijs P. Elstak ED, et al. Among authors: van der sluijs p, van bergen en henegouwen pm. Blood. 2011 Aug 11;118(6):1570-8. doi: 10.1182/blood-2011-02-339523. Epub 2011 Jun 21. Blood. 2011. PMID: 21693760 Free article.
Regulation of membrane transport by rab GTPases.
Deneka M, Neeft M, van der Sluijs P. Deneka M, et al. Among authors: van der sluijs p. Crit Rev Biochem Mol Biol. 2003;38(2):121-42. doi: 10.1080/713609214. Crit Rev Biochem Mol Biol. 2003. PMID: 12749696 Review.
Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex.
de Graaf P, Zwart WT, van Dijken RA, Deneka M, Schulz TK, Geijsen N, Coffer PJ, Gadella BM, Verkleij AJ, van der Sluijs P, van Bergen en Henegouwen PM. de Graaf P, et al. Among authors: van der sluijs p, van dijken ra, van bergen en henegouwen pm. Mol Biol Cell. 2004 Apr;15(4):2038-47. doi: 10.1091/mbc.e03-12-0862. Epub 2004 Feb 6. Mol Biol Cell. 2004. PMID: 14767056 Free PMC article.
Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells.
Neeft M, Wieffer M, de Jong AS, Negroiu G, Metz CH, van Loon A, Griffith J, Krijgsveld J, Wulffraat N, Koch H, Heck AJ, Brose N, Kleijmeer M, van der Sluijs P. Neeft M, et al. Among authors: van der sluijs p, van loon a. Mol Biol Cell. 2005 Feb;16(2):731-41. doi: 10.1091/mbc.e04-10-0923. Epub 2004 Nov 17. Mol Biol Cell. 2005. PMID: 15548590 Free PMC article.
Rab27a is required for human cytomegalovirus assembly.
Fraile-Ramos A, Cepeda V, Elstak E, van der Sluijs P. Fraile-Ramos A, et al. Among authors: van der sluijs p. PLoS One. 2010 Dec 8;5(12):e15318. doi: 10.1371/journal.pone.0015318. PLoS One. 2010. PMID: 21170347 Free PMC article.
A novel Dutch mutation in UNC13D reveals an essential role of the C2B domain in munc13-4 function.
Elstak ED, te Loo M, Tesselaar K, van Kerkhof P, Loeffen J, Grivas D, Hennekam E, Boelens JJ, Hoogerbrugge PM, van der Sluijs P, van Gijn ME, van de Corput L. Elstak ED, et al. Among authors: van der sluijs p, van gijn me, van de corput l, van kerkhof p. Pediatr Blood Cancer. 2012 Apr;58(4):598-605. doi: 10.1002/pbc.23253. Epub 2011 Jul 13. Pediatr Blood Cancer. 2012. PMID: 21755595
125 results