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Latest advances in mechanisms of epileptic activity in Alzheimer's disease and dementia with Lewy Bodies.
Vicente M, Addo-Osafo K, Vossel K. Vicente M, et al. Front Neurol. 2024 Feb 8;15:1277613. doi: 10.3389/fneur.2024.1277613. eCollection 2024. Front Neurol. 2024. PMID: 38390593 Free PMC article. Review.
Patients with AD and DLB exhibit a higher prevalence of epileptic activity compared to those with other forms of dementia. Seizures can accompany AD and DLB in early stages, and the associated epileptic activity can contribute to cognitive symptoms and exacerbate cognitive …
Patients with AD and DLB exhibit a higher prevalence of epileptic activity compared to those with other forms of dementia. Seizures c …
Putting the Brakes on Accelerated Cognitive Decline in Alzheimer's Disease with Epileptic Activity.
Vossel K. Vossel K. J Alzheimers Dis. 2023;94(3):1075-1077. doi: 10.3233/JAD-230613. J Alzheimers Dis. 2023. PMID: 37522212 Free PMC article.
The current study by Hautecloque-Raysz et al. shows that patients with prodromal AD and epilepsy (epAD) fare well with ASD treatment, achieving seizure control in a large majority of cases using low dosage ASDs in monotherapy. Compared to slowly progressing AD patients wit …
The current study by Hautecloque-Raysz et al. shows that patients with prodromal AD and epilepsy (epAD) fare well with ASD treatment, achiev …
Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms.
Hwang K, Vaknalli RN, Addo-Osafo K, Vicente M, Vossel K. Hwang K, et al. Front Aging Neurosci. 2022 Jul 18;14:903973. doi: 10.3389/fnagi.2022.903973. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35923547 Free PMC article. Review.
Furthermore, pharmacological and genetic targeting of tau-based mechanisms can have anti-seizure effects. Suppressing tau phosphorylation decreases seizure activity in acquired epilepsy models while reducing or ablating tau attenuates network hyperexcitability in bo …
Furthermore, pharmacological and genetic targeting of tau-based mechanisms can have anti-seizure effects. Suppressing tau phosphoryla …
Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial.
Vossel K, Ranasinghe KG, Beagle AJ, La A, Ah Pook K, Castro M, Mizuiri D, Honma SM, Venkateswaran N, Koestler M, Zhang W, Mucke L, Howell MJ, Possin KL, Kramer JH, Boxer AL, Miller BL, Nagarajan SS, Kirsch HE. Vossel K, et al. JAMA Neurol. 2021 Nov 1;78(11):1345-1354. doi: 10.1001/jamaneurol.2021.3310. JAMA Neurol. 2021. PMID: 34570177 Free PMC article. Clinical Trial.
Dementia in late-onset epilepsy: The Atherosclerosis Risk in Communities study.
Johnson EL, Krauss GL, Kucharska-Newton A, Albert MS, Brandt J, Walker KA, Yasar S, Knopman DS, Vossel KA, Gottesman RF. Johnson EL, et al. Neurology. 2020 Dec 15;95(24):e3248-e3256. doi: 10.1212/WNL.0000000000011080. Epub 2020 Oct 23. Neurology. 2020. PMID: 33097597 Free PMC article.
METHODS: We used data from the Atherosclerosis Risk in Communities (ARIC) cohort study, which started in 1987 to 1989 with 15,792 mostly Black and White men and women from 4 US communities. We identified late-onset epilepsy (LOE; seizures starting at age 67 or later) from …
METHODS: We used data from the Atherosclerosis Risk in Communities (ARIC) cohort study, which started in 1987 to 1989 with 15,792 mostly Bla …
Ablating Tau Reduces Hyperexcitability and Moderates Electroencephalographic Slowing in Transgenic Mice Expressing A53T Human α-Synuclein.
Peters ST, Fahrenkopf A, Choquette JM, Vermilyea SC, Lee MK, Vossel K. Peters ST, et al. Front Neurol. 2020 Jun 19;11:563. doi: 10.3389/fneur.2020.00563. eCollection 2020. Front Neurol. 2020. PMID: 32636798 Free PMC article.
Significantly, memory deficits were associated with histological signs of network hyperactivity/seizures. Electrophysiological abnormalities are often seen in parkinsonian dementias. Baseline electroencephalogram (EEG) slowing is used as a supportive diagnostic feature in …
Significantly, memory deficits were associated with histological signs of network hyperactivity/seizures. Electrophysiological abnorm …
Relative Incidence of Seizures and Myoclonus in Alzheimer's Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia.
Beagle AJ, Darwish SM, Ranasinghe KG, La AL, Karageorgiou E, Vossel KA. Beagle AJ, et al. J Alzheimers Dis. 2017;60(1):211-223. doi: 10.3233/JAD-170031. J Alzheimers Dis. 2017. PMID: 28826176 Free PMC article.
BACKGROUND: Patients with Alzheimer's disease (AD) are more prone to seizures and myoclonus, but relative risk of these symptoms among other dementia types is unknown. ...Seizures began an average of 3.9 years after the onset of cognitive or motor decline, and myocl …
BACKGROUND: Patients with Alzheimer's disease (AD) are more prone to seizures and myoclonus, but relative risk of these symptoms amon …
Epileptic activity in Alzheimer's disease: causes and clinical relevance.
Vossel KA, Tartaglia MC, Nygaard HB, Zeman AZ, Miller BL. Vossel KA, et al. Lancet Neurol. 2017 Apr;16(4):311-322. doi: 10.1016/S1474-4422(17)30044-3. Lancet Neurol. 2017. PMID: 28327340 Free PMC article. Review.
Epileptic activity is frequently associated with Alzheimer's disease; this association has therapeutic implications, because epileptic activity can occur at early disease stages and might contribute to pathogenesis. In clinical practice, seizures in patients with Alzheimer …
Epileptic activity is frequently associated with Alzheimer's disease; this association has therapeutic implications, because epileptic activ …
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