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Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood.
Li C, Alemany-Ribes M, Raftery RM, Nwoko U, Warman ML, Craft AM. Li C, et al. Ann Rheum Dis. 2023 Dec;82(12):1547-1557. doi: 10.1136/ard-2023-224304. Epub 2023 Sep 7. Ann Rheum Dis. 2023. PMID: 37679035
Therefore, to gain insights into why precocious articular cartilage failure occurs in this disease, we made in vitro derived articular cartilage using isogenic WISP3-deficient and WISP3-sufficient human pluripotent stem cells (hPSCs). ...RESULTS: WISP3-defici …
Therefore, to gain insights into why precocious articular cartilage failure occurs in this disease, we made in vitro derived articular carti …
Frameshift mutation of WISP3 gene and its regional heterogeneity in gastric and colorectal cancers.
Lee JH, Choi YJ, Je EM, Kim HS, Yoo NJ, Lee SH. Lee JH, et al. Hum Pathol. 2016 Apr;50:146-52. doi: 10.1016/j.humpath.2015.12.009. Epub 2015 Dec 30. Hum Pathol. 2016. PMID: 26997449
The aim of our study was to find whether WISP3 gene was mutated and expressionally altered in gastric (GC) and colorectal cancers (CRCs). WISP3 gene possesses a mononucleotide repeat in the coding sequence that could be mutated in cancers with high mic …
The aim of our study was to find whether WISP3 gene was mutated and expressionally altered in gastric (GC) and colorectal canc …
WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice.
Kutz WE, Gong Y, Warman ML. Kutz WE, et al. Mol Cell Biol. 2005 Jan;25(1):414-21. doi: 10.1128/MCB.25.1.414-421.2005. Mol Cell Biol. 2005. PMID: 15601861 Free PMC article.
To understand the role of WISP3 in the skeleton, we targeted the Wisp3 gene in mice by creating a mutant allele comparable to that which causes human disease. ...Mice that overexpress WISP3 are also normal. We conclude, that in contrast to humans, W …
To understand the role of WISP3 in the skeleton, we targeted the Wisp3 gene in mice by creating a mutant allele compara …
WISP3 is a novel tumor suppressor gene of inflammatory breast cancer.
Kleer CG, Zhang Y, Pan Q, van Golen KL, Wu ZF, Livant D, Merajver SD. Kleer CG, et al. Oncogene. 2002 May 9;21(20):3172-80. doi: 10.1038/sj.onc.1205462. Oncogene. 2002. PMID: 12082632
WISP3 transfection was effective in suppressing in vivo tumor growth in nude mice. ...Our data demonstrate that WISP3 acts as a tumor suppressor gene in the breast. Loss of WISP3 expression contributes to the phenotype of IBC by regulating tumor cell g …
WISP3 transfection was effective in suppressing in vivo tumor growth in nude mice. ...Our data demonstrate that WISP3 acts as …
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3 , the gene responsible for Progressive Pseudorheumatoid Arthropathy of Childhood.
Li C, Ribes MA, Raftery R, Nwoko U, Warman ML, Craft AM. Li C, et al. bioRxiv [Preprint]. 2023 Apr 3:2023.04.01.535214. doi: 10.1101/2023.04.01.535214. bioRxiv. 2023. PMID: 37066225 Free PMC article. Updated. Preprint.
RESULTS: WISP3 -deficient and WISP3 -sufficient hPSCs both differentiated into articular cartilage-like tissues that appeared histologically similar. ...Thus, most functional studies of WISP3 have been performed in vitro using WISP3 over-expressing cel …
RESULTS: WISP3 -deficient and WISP3 -sufficient hPSCs both differentiated into articular cartilage-like tissues that appeared …
WISP3 mutation associated with pseudorheumatoid dysplasia.
Sailani MR, Chappell J, Jingga I, Narasimha A, Zia A, Lynch JL, Mazrouei S, Bernstein JA, Aryani O, Snyder MP. Sailani MR, et al. Cold Spring Harb Mol Case Stud. 2018 Feb 1;4(1):a001990. doi: 10.1101/mcs.a001990. Print 2018 Feb. Cold Spring Harb Mol Case Stud. 2018. PMID: 29092958 Free PMC article.
Whole-exome sequencing of four affected siblings and their parents identified a loss-of-function homozygous mutation in the WISP3 gene, leading to diagnosis of PPD in the affected individuals. The identified variant (Chr6: 112382301; WISP3:c.156C>A p.Cys52 …
Whole-exome sequencing of four affected siblings and their parents identified a loss-of-function homozygous mutation in the WISP3 …
WISP3 suppresses ESCC progression by inhibiting the IGF-2-IGF1R-AKT signaling cascade.
Yu X, Mao R, Feng W, Zhao Y, Qin J, Yang Y, Wang A, Shi Z. Yu X, et al. Exp Cell Res. 2021 Dec 1;409(1):112871. doi: 10.1016/j.yexcr.2021.112871. Epub 2021 Oct 19. Exp Cell Res. 2021. PMID: 34672999
On the contrary, WISP3 depletion strongly promoted the tumorigenicity of ESCC cells. Mechanistically, we found that WISP3 negates the activity of AKT via inhibiting the IGF-2-IGF1R signaling cascade, which mediates the tumor-suppressive function of WISP3 in e …
On the contrary, WISP3 depletion strongly promoted the tumorigenicity of ESCC cells. Mechanistically, we found that WISP3 nega …
Association analysis on polymorphisms in WISP3 gene and developmental dysplasia of the hip in Han Chinese population: A case-control study.
Zhang J, Yan M, Zhang Y, Yang H, Sun Y. Zhang J, et al. Gene. 2018 Jul 20;664:192-195. doi: 10.1016/j.gene.2018.04.020. Epub 2018 Apr 20. Gene. 2018. PMID: 29680248
WISP3 gene was found to be a causative gene for progressive pseudorheumatoid dysplasia (PPD). Reports of WISP3 gene in association with DDH are lacking. We conducted a case-control candidate gene association study enrolling three hundred …
WISP3 gene was found to be a causative gene for progressive pseudorheumatoid dysplasia (PPD). Reports of WISP3 …
Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1alpha axis and activating wnt signaling pathway.
Zhou F, Sun J, Ye L, Jiang T, Li W, Su C, Ren S, Wu F, Zhou C, Gao G. Zhou F, et al. Exp Hematol Oncol. 2023 Jul 19;12(1):61. doi: 10.1186/s40164-023-00419-w. Exp Hematol Oncol. 2023. PMID: 37468964 Free PMC article.
As expected, fibronectin activated FAK and its downstream MAPK/ERK signaling pathway. WISP3 was screened as a potential target gene of fibronectin. Interestingly, WISP3 effectively activated Wnt signaling pathway, and knockdown of WISP3 effectively blo …
As expected, fibronectin activated FAK and its downstream MAPK/ERK signaling pathway. WISP3 was screened as a potential target gen …
WISP3 is highly expressed in a subset of colorectal carcinomas with a better prognosis.
Lu Y, Wang X, Sun X, Feng W, Guo H, Tang C, Deng A, Bao Y. Lu Y, et al. Onco Targets Ther. 2016 Jan 12;9:287-93. doi: 10.2147/OTT.S97025. eCollection 2016. Onco Targets Ther. 2016. PMID: 26834488 Free PMC article.
Outlier genes with marked overexpression in subsets of cancers like ERBB2 have potential for the identification of gene classifiers and therapeutic targets for the appropriate subpopulation. ...In summary, in this study, we identified an outlier gene WISP3 …
Outlier genes with marked overexpression in subsets of cancers like ERBB2 have potential for the identification of gene classi …
125 results