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Page 1
Oxfendazole Induces Apoptosis in Ovarian Cancer Cells by Activating JNK/MAPK Pathway and Inducing Reactive Oxygen Species Generation.
Chen Y, Wen C, Zhong S, Huang L, Xiang Y, Ou Y, Li L, Tang W, Zhou C, Wu Z, Ye W, Wu S, Huang S, Li Z. Chen Y, et al. Biol Pharm Bull. 2023;46(11):1569-1575. doi: 10.1248/bpb.b23-00349. Biol Pharm Bull. 2023. PMID: 37914359 Free article.
Ovarian cancer (OC) is one of the most common and high mortality type of cancer among women worldwide. ...Recent study has shown that one of the benzimidazole anthelmintics oxfendazole inhibited cell growth of non-small cell lung cancer cells, revealin …
Ovarian cancer (OC) is one of the most common and high mortality type of cancer among women worldwide. ...Recent study has sho …
The anthelmintic agent oxfendazole inhibits cell growth in non-small cell lung cancer by suppressing c-Src activation.
Xu D, Tian W, Jiang C, Huang Z, Zheng S. Xu D, et al. Mol Med Rep. 2019 Apr;19(4):2921-2926. doi: 10.3892/mmr.2019.9897. Epub 2019 Jan 28. Mol Med Rep. 2019. PMID: 30720086
Oxfendazole also suppressed the cell growth of non-small cell lung cancer (NSCLC) cells, and overexpression of c-Src decreased the cytotoxicity of oxfendazole against NSCLC cells. ...Furthermore, oxfendazole enhanced the cytotoxicity of cisplatin again …
Oxfendazole also suppressed the cell growth of non-small cell lung cancer (NSCLC) cells, and overexpression of c-Src decreased …
Network pharmacology and molecular docking study-based approach to explore mechanism of benzimidazole-based anthelmintics for the treatment of lung cancer.
Garg A, Karhana S, Bano A, Khan IA, Reeta, Nidhi, Khan MA. Garg A, et al. J Biomol Struct Dyn. 2023 Sep 23:1-22. doi: 10.1080/07391102.2023.2258419. Online ahead of print. J Biomol Struct Dyn. 2023. PMID: 37740654
Emerging studies have reported the potential anticancer activity of benzimidazole-based anthelmintics (BBA) against lung cancer (LC). However, mechanism underlying the anticancer activity of BBA is unclear. ...BBA can be further explored as a therapeutic strategy for the t …
Emerging studies have reported the potential anticancer activity of benzimidazole-based anthelmintics (BBA) against lung cancer (LC). …
Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies.
Codd EE, Ng HH, McFarlane C, Riccio ES, Doppalapudi R, Mirsalis JC, Horton RJ, Gonzalez AE, Garcia HH, Gilman RH; Cysticercosis Working Group in Peru. Codd EE, et al. Int J Toxicol. 2015 Mar-Apr;34(2):129-37. doi: 10.1177/1091581815569582. Epub 2015 Feb 20. Int J Toxicol. 2015. PMID: 25701764 Free PMC article.
A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thymus. Female rats had greater oxfendazole exposure and exhibited toxicities at lower doses than did males. ...
A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thy …
The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs.
Son DS, Lee ES, Adunyah SE. Son DS, et al. Immune Netw. 2020 Aug 4;20(4):e29. doi: 10.4110/in.2020.20.e29. eCollection 2020 Aug. Immune Netw. 2020. PMID: 32895616 Free PMC article. Review.
Above all, these anthelmintics may offer a broad, safe spectrum to treat cancer, as demonstrated by their long history of use as antiparasitic agents. The present review summarizes central literature regarding the anticancer effects of benzimidazole anthelmintics, includin …
Above all, these anthelmintics may offer a broad, safe spectrum to treat cancer, as demonstrated by their long history of use as anti …
A new insight of immunosuppressive microenvironment in osteosarcoma lung metastasis.
He M, Jiang X, Miao J, Feng W, Xie T, Liao S, Qin Z, Tang H, Lin C, Li B, Xu J, Liu Y, Mo Z, Wei Q. He M, et al. Exp Biol Med (Maywood). 2023 Jun;248(12):1056-1073. doi: 10.1177/15353702231171900. Epub 2023 Jul 13. Exp Biol Med (Maywood). 2023. PMID: 37439349 Free PMC article.
Finally, we unveiled C1_Therapeutic cluster, a subcluster of malignant cells, was sensitive to oxfendazole and mevastatin, and the potential hydrogen-bond position and binding energy of oxfendazole-KIAA0907 and mevastatin-KIAA0907 were unveiled, respectively. ...
Finally, we unveiled C1_Therapeutic cluster, a subcluster of malignant cells, was sensitive to oxfendazole and mevastatin, and the po …
Immunomodulatory effect of various anti-parasitics: a review.
Sajid MS, Iqbal Z, Muhammad G, Iqbal MU. Sajid MS, et al. Parasitology. 2006 Mar;132(Pt 3):301-13. doi: 10.1017/S0031182005009108. Epub 2005 Dec 7. Parasitology. 2006. PMID: 16332285 Review.
This paper reviews the immunomodulatory effects (immunosuppression or immunoactivation) of various anthelmintics including levamisole, fenvalerate, dieldrin, carbofuran, aminocarb, thiabendazole, fenbendazole, oxfendazole and ivermectin. The induced modulation of immune fu …
This paper reviews the immunomodulatory effects (immunosuppression or immunoactivation) of various anthelmintics including levamisole, fenva …
Liver tumour-promoting effects of oxfendazole in rats.
Mitsumori K, Onodera H, Shoda T, Uneyama C, Imazawa T, Takegawa K, Yasuhara K, Watanabe T, Takahashi M. Mitsumori K, et al. Food Chem Toxicol. 1997 Aug;35(8):799-806. doi: 10.1016/s0278-6915(97)00051-3. Food Chem Toxicol. 1997. PMID: 9350225
To examine whether oxfendazole has tumour-promoting activity, a total of 100 male Fisher 344 rats were initiated with a single ip injection of 100 mg/kg of diethylnitrosamine (DEN) or given saline vehicle alone and starting 1 wk later given diet containing 500, 250, 100, 1 …
To examine whether oxfendazole has tumour-promoting activity, a total of 100 male Fisher 344 rats were initiated with a single ip inj …
Preparation and evaluation of fenbendazole methyl-β-cyclodextrin inclusion complexes.
Ding Y, Zhang Z, Ding C, Xu S, Xu Z. Ding Y, et al. BMC Vet Res. 2024 May 20;20(1):214. doi: 10.1186/s12917-024-04056-1. BMC Vet Res. 2024. PMID: 38769544 Free PMC article.
As an orally effective benzimidazole anthelmintic agent, fenbendazole was not only widely used in agriculture and animal husbandry to prevent and treat parasites, but also shows anti-cancer effects against several types of cancer, exhibits anti-cancer effects …
As an orally effective benzimidazole anthelmintic agent, fenbendazole was not only widely used in agriculture and animal husbandry to preven …
Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats.
Nishimura J, Saegusa Y, Dewa Y, Jin M, Kawai M, Kemmochi S, Harada T, Hayashi SM, Shibutani M, Mitsumori K. Nishimura J, et al. Arch Toxicol. 2010 Feb;84(2):143-53. doi: 10.1007/s00204-009-0497-9. Epub 2009 Dec 22. Arch Toxicol. 2010. PMID: 20033131
To clarify whether enzymatically modified isoquercitrin (EMIQ) or melatonin (MLT) supplementation reduces oxidative stress-mediated hepatocellular tumor-promoting effect of oxfendazole (OX), a benzimidazole anthelmintic, male rats were administered a single intraperitoneal …
To clarify whether enzymatically modified isoquercitrin (EMIQ) or melatonin (MLT) supplementation reduces oxidative stress-mediated hepatoce …
19 results