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19 results

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Page 1
Oxfendazole Induces Apoptosis in Ovarian Cancer Cells by Activating JNK/MAPK Pathway and Inducing Reactive Oxygen Species Generation.
Chen Y, Wen C, Zhong S, Huang L, Xiang Y, Ou Y, Li L, Tang W, Zhou C, Wu Z, Ye W, Wu S, Huang S, Li Z. Chen Y, et al. Biol Pharm Bull. 2023;46(11):1569-1575. doi: 10.1248/bpb.b23-00349. Biol Pharm Bull. 2023. PMID: 37914359 Free article.
Ovarian cancer (OC) is one of the most common and high mortality type of cancer among women worldwide. ...Benzimidazole anthelmintics might have the promising efficacy for cancer therapy as their selectively binding activity to beta-tubulin. Recent study has …
Ovarian cancer (OC) is one of the most common and high mortality type of cancer among women worldwide. ...Benzimidazole anthel …
The anthelmintic agent oxfendazole inhibits cell growth in non-small cell lung cancer by suppressing c-Src activation.
Xu D, Tian W, Jiang C, Huang Z, Zheng S. Xu D, et al. Mol Med Rep. 2019 Apr;19(4):2921-2926. doi: 10.3892/mmr.2019.9897. Epub 2019 Jan 28. Mol Med Rep. 2019. PMID: 30720086
Oxfendazole also suppressed the cell growth of non-small cell lung cancer (NSCLC) cells, and overexpression of c-Src decreased the cytotoxicity of oxfendazole against NSCLC cells. ...Furthermore, oxfendazole enhanced the cytotoxicity of cisplatin again
Oxfendazole also suppressed the cell growth of non-small cell lung cancer (NSCLC) cells, and overexpression of c-Src decreased
Network pharmacology and molecular docking study-based approach to explore mechanism of benzimidazole-based anthelmintics for the treatment of lung cancer.
Garg A, Karhana S, Bano A, Khan IA, Reeta, Nidhi, Khan MA. Garg A, et al. J Biomol Struct Dyn. 2023 Sep 23:1-22. doi: 10.1080/07391102.2023.2258419. Online ahead of print. J Biomol Struct Dyn. 2023. PMID: 37740654
Emerging studies have reported the potential anticancer activity of benzimidazole-based anthelmintics (BBA) against lung cancer (LC). However, mechanism underlying the anticancer activity of BBA is unclear. Therefore, in the current study, network pharmacology and molecula …
Emerging studies have reported the potential anticancer activity of benzimidazole-based anthelmintics (BBA) against lung cancer (LC). …
The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs.
Son DS, Lee ES, Adunyah SE. Son DS, et al. Immune Netw. 2020 Aug 4;20(4):e29. doi: 10.4110/in.2020.20.e29. eCollection 2020 Aug. Immune Netw. 2020. PMID: 32895616 Free PMC article. Review.
The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival. ...Above all, these anthelmintics may offer a broad, safe spectrum to treat cance
The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular prolif …
A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut-supporting/immune enhancing molecules.
Iragavarapu-Charyulu V, Shakya R, Robinson P, Guzmán E, Tyulmenkova A, Pino JL, Isgor C. Iragavarapu-Charyulu V, et al. Oncol Rep. 2024 Feb;51(2):31. doi: 10.3892/or.2023.8690. Epub 2023 Dec 22. Oncol Rep. 2024. PMID: 38131223
At the primary tumor, SCFA receptor FFAR2 expression was increased in combination treatment compared with untreated mice, suggestive of a non-invasive cancer phenotype. The superior cytotoxic effects of OFZ/PBZ were confirmed as opposed to single treatment with OFZ or PBZ …
At the primary tumor, SCFA receptor FFAR2 expression was increased in combination treatment compared with untreated mice, suggestive of a no …
A new insight of immunosuppressive microenvironment in osteosarcoma lung metastasis.
He M, Jiang X, Miao J, Feng W, Xie T, Liao S, Qin Z, Tang H, Lin C, Li B, Xu J, Liu Y, Mo Z, Wei Q. He M, et al. Exp Biol Med (Maywood). 2023 Jun;248(12):1056-1073. doi: 10.1177/15353702231171900. Epub 2023 Jul 13. Exp Biol Med (Maywood). 2023. PMID: 37439349 Free PMC article.
Finally, we unveiled C1_Therapeutic cluster, a subcluster of malignant cells, was sensitive to oxfendazole and mevastatin, and the potential hydrogen-bond position and binding energy of oxfendazole-KIAA0907 and mevastatin-KIAA0907 were unveiled, respectively. ...
Finally, we unveiled C1_Therapeutic cluster, a subcluster of malignant cells, was sensitive to oxfendazole and mevastatin, and the po …
Understanding the pathogenic mechanisms and therapeutic effects in neurocysticercosis.
Castillo G, Fustamante L, Delgado-Kamiche AD, Camen-Orozco RP, Clark T, Bernal E, Morales-Alvarez J, Ferrufino M, Mamani-Palomino J, Bustos JA, Garcia HH, Gavidia CM, Gilman RH, Verastegui M; Cysticercosis Working Group in Peru. Castillo G, et al. Brain Pathol. 2024 Sep;34(5):e13237. doi: 10.1111/bpa.13237. Epub 2024 Jan 11. Brain Pathol. 2024. PMID: 38212958 Free PMC article.
Rats were intracranially infected with Taenia solium oncospheres and treated with albendazole + praziquantel (ABZ), oxfendazole + praziquantel (OXF), or untreated placebo (UT) for 7 days. Following the last dose of treatment, brain tissues were evaluated at 24 h and 2 mont …
Rats were intracranially infected with Taenia solium oncospheres and treated with albendazole + praziquantel (ABZ), oxfendazole + pra …
Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies.
Codd EE, Ng HH, McFarlane C, Riccio ES, Doppalapudi R, Mirsalis JC, Horton RJ, Gonzalez AE, Garcia HH, Gilman RH; Cysticercosis Working Group in Peru. Codd EE, et al. Int J Toxicol. 2015 Mar-Apr;34(2):129-37. doi: 10.1177/1091581815569582. Epub 2015 Feb 20. Int J Toxicol. 2015. PMID: 25701764 Free PMC article.
A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thymus. Female rats had greater oxfendazole exposure and exhibited toxicities at lower doses than did males. ...These results support th …
A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thy …
Immunomodulatory effect of various anti-parasitics: a review.
Sajid MS, Iqbal Z, Muhammad G, Iqbal MU. Sajid MS, et al. Parasitology. 2006 Mar;132(Pt 3):301-13. doi: 10.1017/S0031182005009108. Epub 2005 Dec 7. Parasitology. 2006. PMID: 16332285 Review.
This paper reviews the immunomodulatory effects (immunosuppression or immunoactivation) of various anthelmintics including levamisole, fenvalerate, dieldrin, carbofuran, aminocarb, thiabendazole, fenbendazole, oxfendazole and ivermectin. The induced modulation of immune fu …
This paper reviews the immunomodulatory effects (immunosuppression or immunoactivation) of various anthelmintics including levamisole, fenva …
Preparation and evaluation of fenbendazole methyl-β-cyclodextrin inclusion complexes.
Ding Y, Zhang Z, Ding C, Xu S, Xu Z. Ding Y, et al. BMC Vet Res. 2024 May 20;20(1):214. doi: 10.1186/s12917-024-04056-1. BMC Vet Res. 2024. PMID: 38769544 Free PMC article.
As an orally effective benzimidazole anthelmintic agent, fenbendazole was not only widely used in agriculture and animal husbandry to prevent and treat parasites, but also shows anti-cancer effects against several types of cancer, exhibits anti-cancer effects …
As an orally effective benzimidazole anthelmintic agent, fenbendazole was not only widely used in agriculture and animal husbandry to preven …
19 results