Brady KD - Search Results

1

Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery.

Talanian RV, Brady KD, Cryns VL. Talanian RV, et al. Among authors: brady kd. J Med Chem. 2000 Sep 7;43(18):3351-71. doi: 10.1021/jm000060f. J Med Chem. 2000. PMID: 10978183 Review. No abstract available.

2

Substrate specificities of caspase family proteases.

Talanian RV, Quinlan C, Trautz S, Hackett MC, Mankovich JA, Banach D, Ghayur T, Brady KD, Wong WW. Talanian RV, et al. Among authors: brady kd. J Biol Chem. 1997 Apr 11;272(15):9677-82. doi: 10.1074/jbc.272.15.9677. J Biol Chem. 1997. PMID: 9092497 Free article.

3

A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones.

Brady KD, Giegel DA, Grinnell C, Lunney E, Talanian RV, Wong W, Walker N. Brady KD, et al. Bioorg Med Chem. 1999 Apr;7(4):621-31. doi: 10.1016/s0968-0896(99)00009-7. Bioorg Med Chem. 1999. PMID: 10353641

4

Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1).

Shahripour AB, Plummer MS, Lunney EA, Albrecht HP, Hays SJ, Kostlan CR, Sawyer TK, Walker NP, Brady KD, Allen HJ, Talanian RV, Wong WW, Humblet C. Shahripour AB, et al. Among authors: brady kd. Bioorg Med Chem. 2002 Jan;10(1):31-40. doi: 10.1016/s0968-0896(01)00250-4. Bioorg Med Chem. 2002. PMID: 11738604

5

Stability and oligomeric equilibria of refolded interleukin-1beta converting enzyme.

Talanian RV, Dang LC, Ferenz CR, Hackett MC, Mankovich JA, Welch JP, Wong WW, Brady KD. Talanian RV, et al. Among authors: brady kd. J Biol Chem. 1996 Sep 6;271(36):21853-8. doi: 10.1074/jbc.271.36.21853. J Biol Chem. 1996. PMID: 8702986 Free article.

6

Preparation of an autolysis-resistant interleukin-1 beta converting enzyme mutant.

Dang LC, Talanian RV, Banach D, Hackett MC, Gilmore JL, Hays SJ, Mankovich JA, Brady KD. Dang LC, et al. Among authors: brady kd. Biochemistry. 1996 Nov 26;35(47):14910-6. doi: 10.1021/bi9617771. Biochemistry. 1996. PMID: 8942655

7

Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide.

Shahripour AB, Plummer MS, Lunney EA, Sawyer TK, Stankovic CJ, Connolly MK, Rubin JR, Walker NP, Brady KD, Allen HJ, Talanian RV, Wong WW, Humblet C. Shahripour AB, et al. Among authors: brady kd. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2779-82. doi: 10.1016/s0960-894x(01)00573-x. Bioorg Med Chem Lett. 2001. PMID: 11591522

8

Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).

Galatsis P, Caprathe B, Gilmore J, Thomas A, Linn K, Sheehan S, Harter W, Kostlan C, Lunney E, Stankovic C, Rubin J, Brady K, Allen H, Talanian R. Galatsis P, et al. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5184-90. doi: 10.1016/j.bmcl.2010.07.004. Epub 2010 Jul 8. Bioorg Med Chem Lett. 2010. PMID: 20656488

9

Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones.

Galatsis P, Caprathe B, Downing D, Gilmore J, Harter W, Hays S, Kostlan C, Linn K, Lunney E, Para K, Thomas A, Warmus J, Allen H, Brady K, Talanian R, Walker N. Galatsis P, et al. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5089-94. doi: 10.1016/j.bmcl.2010.07.031. Epub 2010 Jul 11. Bioorg Med Chem Lett. 2010. PMID: 20674352

10

Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer.

Walker NP, Talanian RV, Brady KD, Dang LC, Bump NJ, Ferenz CR, Franklin S, Ghayur T, Hackett MC, Hammill LD, et al. Walker NP, et al. Among authors: brady kd. Cell. 1994 Jul 29;78(2):343-52. doi: 10.1016/0092-8674(94)90303-4. Cell. 1994. PMID: 8044845

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