Panek RL - Search Results

1

Design of a functional hexapeptide antagonist of endothelin.

Cody WL, Doherty AM, He JX, DePue PL, Rapundalo ST, Hingorani GA, Major TC, Panek RL, Dudley DT, Haleen SJ, et al. Cody WL, et al. Among authors: panek rl. J Med Chem. 1992 Aug 21;35(17):3301-3. doi: 10.1021/jm00095a029. J Med Chem. 1992. PMID: 1324321 No abstract available.

2

Endothelin and structurally related analogs distinguish between endothelin receptor subtypes.

Panek RL, Major TC, Hingorani GP, Doherty AM, Taylor DG, Rapundalo ST. Panek RL, et al. Biochem Biophys Res Commun. 1992 Mar 16;183(2):566-71. doi: 10.1016/0006-291x(92)90519-q. Biochem Biophys Res Commun. 1992. PMID: 1312833

3

Importance of secondary structure for endothelin binding and functional activity.

Panek RL, Major TC, Taylor DG, Hingorani GP, Dunbar JB, Doherty AM, Rapundalo ST. Panek RL, et al. Biochem Biophys Res Commun. 1992 Mar 16;183(2):572-6. doi: 10.1016/0006-291x(92)90520-u. Biochem Biophys Res Commun. 1992. PMID: 1550565

4

Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists.

Sircar I, Winters RT, Quin J 3rd, Lu GH, Major TC, Panek RL. Sircar I, et al. Among authors: panek rl. J Med Chem. 1993 Jun 11;36(12):1735-45. doi: 10.1021/jm00064a007. J Med Chem. 1993. PMID: 8510101

5

Structure-activity studies of phosphorylated peptide inhibitors of the association of phosphatidylinositol 3-kinase with PDGF-beta receptor.

Ramalingam K, Eaton SR, Cody WL, Lu GH, Panek RL, Waite LA, Decker SJ, Keiser JA, Doherty AM. Ramalingam K, et al. Among authors: panek rl. Bioorg Med Chem. 1995 Sep;3(9):1263-72. doi: 10.1016/0968-0896(95)00112-t. Bioorg Med Chem. 1995. PMID: 8564419

6

Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.

Hamby JM, Connolly CJ, Schroeder MC, Winters RT, Showalter HD, Panek RL, Major TC, Olsewski B, Ryan MJ, Dahring T, Lu GH, Keiser J, Amar A, Shen C, Kraker AJ, Slintak V, Nelson JM, Fry DW, Bradford L, Hallak H, Doherty AM. Hamby JM, et al. Among authors: panek rl. J Med Chem. 1997 Jul 18;40(15):2296-303. doi: 10.1021/jm970367n. J Med Chem. 1997. PMID: 9240345

7

Design of peptidomimetics that inhibit the association of phosphatidylinositol 3-kinase with platelet-derived growth factor-beta receptor and possess cellular activity.

Eaton SR, Cody WL, Doherty AM, Holland DR, Panek RL, Lu GH, Dahring TK, Rose DR. Eaton SR, et al. Among authors: panek rl. J Med Chem. 1998 Oct 22;41(22):4329-42. doi: 10.1021/jm9802766. J Med Chem. 1998. PMID: 9784108

8

Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido[2,3-d]pyrimidines: identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitors.

Boschelli DH, Wu Z, Klutchko SR, Showalter HD, Hamby JM, Lu GH, Major TC, Dahring TK, Batley B, Panek RL, Keiser J, Hartl BG, Kraker AJ, Klohs WD, Roberts BJ, Patmore S, Elliott WL, Steinkampf R, Bradford LA, Hallak H, Doherty AM. Boschelli DH, et al. Among authors: panek rl. J Med Chem. 1998 Oct 22;41(22):4365-77. doi: 10.1021/jm980398y. J Med Chem. 1998. PMID: 9784112

9

Subclasses of cyclic GMP-specific phosphodiesterase and their role in regulating the effects of atrial natriuretic factor.

Weishaar RE, Kobylarz-Singer DC, Keiser J, Haleen SJ, Major TC, Rapundalo S, Peterson JT, Panek R. Weishaar RE, et al. Hypertension. 1990 May;15(5):528-40. doi: 10.1161/01.hyp.15.5.528. Hypertension. 1990. PMID: 2158939

10

Structure-activity studies of the C-terminal region of the endothelins and the sarafotoxins.

Doherty AM, Cody WL, Leitz NL, DePue PL, Taylor MD, Rapundalo ST, Hingorani GP, Major TC, Panek RL, Taylor DG. Doherty AM, et al. Among authors: panek rl. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S59-61. doi: 10.1097/00005344-199100177-00016. J Cardiovasc Pharmacol. 1991. PMID: 1725433

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