Melin P - Search Results

1

Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat.

Norez C, Noel S, Wilke M, Bijvelds M, Jorna H, Melin P, DeJonge H, Becq F. Norez C, et al. Among authors: melin p. FEBS Lett. 2006 Apr 3;580(8):2081-6. doi: 10.1016/j.febslet.2006.03.010. Epub 2006 Mar 10. FEBS Lett. 2006. PMID: 16546175 Free article.

2

The cystic fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein.

Melin P, Thoreau V, Norez C, Bilan F, Kitzis A, Becq F. Melin P, et al. Biochem Pharmacol. 2004 Jun 15;67(12):2187-96. doi: 10.1016/j.bcp.2004.02.022. Biochem Pharmacol. 2004. PMID: 15163550

3

The glycine residues G551 and G1349 within the ATP-binding cassette signature motifs play critical roles in the activation and inhibition of cystic fibrosis transmembrane conductance regulator channels by phloxine B.

Melin P, Norez C, Callebaut I, Becq F. Melin P, et al. J Membr Biol. 2005 Dec;208(3):203-12. doi: 10.1007/s00232-005-7001-0. Epub 2006 Apr 7. J Membr Biol. 2005. PMID: 16604470

4

Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

Vandebrouck C, Melin P, Norez C, Robert R, Guibert C, Mettey Y, Becq F. Vandebrouck C, et al. Among authors: melin p. Respir Res. 2006 Aug 28;7(1):113. doi: 10.1186/1465-9921-7-113. Respir Res. 2006. PMID: 16938132 Free PMC article.

5

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.

Routaboul C, Norez C, Melin P, Molina MC, Boucherle B, Bossard F, Noel S, Robert R, Gauthier C, Becq F, Décout JL. Routaboul C, et al. Among authors: melin p. J Pharmacol Exp Ther. 2007 Sep;322(3):1023-35. doi: 10.1124/jpet.107.123307. Epub 2007 Jun 19. J Pharmacol Exp Ther. 2007. PMID: 17578899

6

CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three.

Melin P, Hosy E, Vivaudou M, Becq F. Melin P, et al. Biochim Biophys Acta. 2007 Oct;1768(10):2438-46. doi: 10.1016/j.bbamem.2007.05.013. Epub 2007 May 21. Biochim Biophys Acta. 2007. PMID: 17582383 Free article.

7

Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells.

Bilan F, Nacfer M, Fresquet F, Norez C, Melin P, Martin-Berge A, Costa de Beauregard MA, Becq F, Kitzis A, Thoreau V. Bilan F, et al. Among authors: melin p. Exp Cell Res. 2008 Jul 1;314(11-12):2199-211. doi: 10.1016/j.yexcr.2008.04.012. Epub 2008 May 4. Exp Cell Res. 2008. PMID: 18570918

8

C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.

Billet A, Melin P, Jollivet M, Mornon JP, Callebaut I, Becq F. Billet A, et al. Among authors: melin p. J Biol Chem. 2010 Jul 16;285(29):22132-40. doi: 10.1074/jbc.M110.120683. Epub 2010 Apr 30. J Biol Chem. 2010. PMID: 20435887 Free PMC article.

9

Orphan missense mutations in the cystic fibrosis transmembrane conductance regulator: A three-step biological approach to establishing a correlation between genotype and phenotype.

Fresquet F, Clement R, Norez C, Sterlin A, Melin P, Becq F, Kitzis A, Thoreau V, Bilan F. Fresquet F, et al. Among authors: melin p. J Mol Diagn. 2011 Sep;13(5):520-7. doi: 10.1016/j.jmoldx.2011.05.004. Epub 2011 Jun 25. J Mol Diagn. 2011. PMID: 21708286 Free PMC article.

10

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

Granio O, Ashbourne Excoffon KJ, Henning P, Melin P, Norez C, Gonzalez G, Karp PH, Magnusson MK, Habib N, Lindholm L, Becq F, Boulanger P, Zabner J, Hong SS. Granio O, et al. Among authors: melin p. Hum Gene Ther. 2010 Mar;21(3):251-69. doi: 10.1089/hum.2009.056. Hum Gene Ther. 2010. PMID: 19788389

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