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Allosteric regulation of substrate channeling in tryptophan synthase: modulation of the L-serine reaction in stage I of the beta-reaction by alpha-site ligands.
Ngo H, Kimmich N, Harris R, Niks D, Blumenstein L, Kulik V, Barends TR, Schlichting I, Dunn MF. Ngo H, et al. Among authors: harris r. Biochemistry. 2007 Jul 3;46(26):7740-53. doi: 10.1021/bi7003872. Epub 2007 Jun 9. Biochemistry. 2007. PMID: 17559232
To derive a structure-based mechanism for stage I, X-ray structures of both the E(Aex1) and E(A-A) states complexed with the different ASLs were determined and compared with structures of the ASL complexes with the internal aldimine [Ngo, H., Harris, R., Kimmich, N. …
To derive a structure-based mechanism for stage I, X-ray structures of both the E(Aex1) and E(A-A) states complexed with the different ASLs …
Synergistic effects on escape of a ligand from the closed tryptophan synthase bienzyme complex.
Harris RM, Ngo H, Dunn MF. Harris RM, et al. Biochemistry. 2005 Dec 27;44(51):16886-95. doi: 10.1021/bi0516881. Biochemistry. 2005. PMID: 16363802
At the alpha-site, indole is cleaved from 3-indole-D-glycerol 3'-phosphate (IGP) and is channeled to the beta-site via a tunnel. Harris and Dunn [Harris, R. M., and Dunn, M. F. (2002) Biochemistry 41, 9982-9990] showed that when the novel amino acid, dihydroi …
At the alpha-site, indole is cleaved from 3-indole-D-glycerol 3'-phosphate (IGP) and is channeled to the beta-site via a tunnel. Harris …
Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans.
Li Y, Ramírez-Suástegui C, Harris R, Castañeda-Castro FE, Ascui G, Pérez-Jeldres T, Diaz A, Morong C, Giles DA, Chai J, Seumois G, Sanchez-Elsner T, Cummings F, Kronenberg M, Vijayanand P. Li Y, et al. Among authors: harris r. Nat Immunol. 2024 Jun 19. doi: 10.1038/s41590-024-01860-7. Online ahead of print. Nat Immunol. 2024. PMID: 38898157
Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2.
Zhang Y, Bock F, Ferdaus M, Arroyo JP, L Rose K, Patel P, Denton JS, Delpire E, Weinstein AM, Zhang MZ, Harris RC, Terker AS. Zhang Y, et al. Among authors: harris rc. Nat Commun. 2024 Jun 17;15(1):5144. doi: 10.1038/s41467-024-49562-w. Nat Commun. 2024. PMID: 38886379 Free PMC article.
Electron transport chain inhibition increases cellular dependence on purine transport and salvage.
Wu Z, Bezwada D, Cai F, Harris RC, Ko B, Sondhi V, Pan C, Vu HS, Nguyen PT, Faubert B, Cai L, Chen H, Martin-Sandoval M, Do D, Gu W, Zhang Y, Zhang Y, Brooks B, Kelekar S, Zacharias LG, Oaxaca KC, Patricio JS, Mathews TP, Garcia-Bermudez J, Ni M, DeBerardinis RJ. Wu Z, et al. Among authors: harris rc. Cell Metab. 2024 Jun 7:S1550-4131(24)00190-6. doi: 10.1016/j.cmet.2024.05.014. Online ahead of print. Cell Metab. 2024. PMID: 38876105 Free article.
7,832 results