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5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids.
Sapieha P, Stahl A, Chen J, Seaward MR, Willett KL, Krah NM, Dennison RJ, Connor KM, Aderman CM, Liclican E, Carughi A, Perelman D, Kanaoka Y, Sangiovanni JP, Gronert K, Smith LE. Sapieha P, et al. Among authors: sangiovanni jp. Sci Transl Med. 2011 Feb 9;3(69):69ra12. doi: 10.1126/scitranslmed.3001571. Sci Transl Med. 2011. PMID: 21307302 Free PMC article.
Dietary ω-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin.
Fu Z, Lofqvist CA, Shao Z, Sun Y, Joyal JS, Hurst CG, Cui RZ, Evans LP, Tian K, SanGiovanni JP, Chen J, Ley D, Hansen Pupp I, Hellstrom A, Smith LE. Fu Z, et al. Among authors: sangiovanni jp. Am J Clin Nutr. 2015 Apr;101(4):879-88. doi: 10.3945/ajcn.114.099291. Epub 2015 Feb 4. Am J Clin Nutr. 2015. PMID: 25833984 Free PMC article.
The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23.
SanGiovanni JP, Chew EY, Agrón E, Clemons TE, Ferris FL 3rd, Gensler G, Lindblad AS, Milton RC, Seddon JM, Klein R, Sperduto RD; Age-Related Eye Disease Study Research Group. SanGiovanni JP, et al. Arch Ophthalmol. 2008 Sep;126(9):1274-9. doi: 10.1001/archopht.126.9.1274. Arch Ophthalmol. 2008. PMID: 18779490 Free PMC article. Clinical Trial.
DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ω-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways.
SanGiovanni JP, Chen J, Sapieha P, Aderman CM, Stahl A, Clemons TE, Chew EY, Smith LE. SanGiovanni JP, et al. PLoS One. 2013;8(1):e53155. doi: 10.1371/journal.pone.0053155. Epub 2013 Jan 15. PLoS One. 2013. PMID: 23335958 Free PMC article.
Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization.
Gong Y, Fu Z, Edin ML, Liu CH, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Lee KS, Moran EP, SanGiovanni JP, Hellström A, Hammock BD, Zeldin DC, Smith LE. Gong Y, et al. Among authors: sangiovanni jp. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1919-27. doi: 10.1161/ATVBAHA.116.307558. Epub 2016 Jul 14. Arterioscler Thromb Vasc Biol. 2016. PMID: 27417579 Free PMC article.
70 results