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Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.
Nucleic Acids Res. 2010 May;38(9):2944-54. doi: 10.1093/nar/gkp1252. Epub 2010 Feb 4.
Nucleic Acids Res. 2010.
PMID: 20139091
Free PMC article.
Rag mutations reveal robust alternative end joining.
Corneo B, Wendland RL, Deriano L, Cui X, Klein IA, Wong SY, Arnal S, Holub AJ, Weller GR, Pancake BA, Shah S, Brandt VL, Meek K, Roth DB.
Corneo B, et al.
Nature. 2007 Sep 27;449(7161):483-6. doi: 10.1038/nature06168.
Nature. 2007.
PMID: 17898768
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RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.
Coussens MA, Wendland RL, Deriano L, Lindsay CR, Arnal SM, Roth DB.
Coussens MA, et al. Among authors: arnal sm.
Cell Rep. 2013 Sep 12;4(5):870-8. doi: 10.1016/j.celrep.2013.07.041. Epub 2013 Aug 29.
Cell Rep. 2013.
PMID: 23994475
Free PMC article.
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Excised V(D)J recombination byproducts threaten genomic integrity.
Arnal SM, Roth DB.
Arnal SM, et al.
Trends Immunol. 2007 Jul;28(7):289-92. doi: 10.1016/j.it.2007.05.006. Epub 2007 Jun 4.
Trends Immunol. 2007.
PMID: 17544847
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The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect.
Hewitt SL, Wong JB, Lee JH, Nishana M, Chen H, Coussens M, Arnal SM, Blumenberg LM, Roth DB, Paull TT, Skok JA.
Hewitt SL, et al. Among authors: arnal sm.
Cell Rep. 2017 Oct 24;21(4):979-993. doi: 10.1016/j.celrep.2017.09.084.
Cell Rep. 2017.
PMID: 29069605
Free PMC article.
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MOZ increases p53 acetylation and premature senescence through its complex formation with PML.
Rokudai S, Laptenko O, Arnal SM, Taya Y, Kitabayashi I, Prives C.
Rokudai S, et al. Among authors: arnal sm.
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3895-900. doi: 10.1073/pnas.1300490110. Epub 2013 Feb 19.
Proc Natl Acad Sci U S A. 2013.
PMID: 23431171
Free PMC article.
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Genetic dissection of p23, an Hsp90 cochaperone, reveals a distinct surface involved in estrogen receptor signaling.
Oxelmark E, Knoblauch R, Arnal S, Su LF, Schapira M, Garabedian MJ.
Oxelmark E, et al.
J Biol Chem. 2003 Sep 19;278(38):36547-55. doi: 10.1074/jbc.M305960200. Epub 2003 Jun 30.
J Biol Chem. 2003.
PMID: 12835317
Free article.
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Analytical Validation and Performance of a 7-Gene Next-Generation Sequencing Panel in Uveal Melanoma.
Alsina KM, Sholl LM, Covington KR, Arnal SM, Durante MA, Decatur CL, Stone JF, Oelschlager KM, Harbour JW, Monzon FA, Cook RW, Borman S.
Alsina KM, et al. Among authors: arnal sm.
Ocul Oncol Pathol. 2021 Dec;7(6):428-436. doi: 10.1159/000518829. Epub 2021 Aug 4.
Ocul Oncol Pathol. 2021.
PMID: 35083209
Free PMC article.
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