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The marine compound spongistatin 1 targets pancreatic tumor progression and metastasis.
Int J Cancer. 2010 Sep 1;127(5):1096-105. doi: 10.1002/ijc.25241.
Int J Cancer. 2010.
PMID: 20143389
The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Wiedmann RM, von Schwarzenberg K, Palamidessi A, Schreiner L, Kubisch R, Liebl J, Schempp C, Trauner D, Vereb G, Zahler S, Wagner E, Müller R, Scita G, Vollmar AM.
Wiedmann RM, et al.
Cancer Res. 2012 Nov 15;72(22):5976-87. doi: 10.1158/0008-5472.CAN-12-1772. Epub 2012 Sep 17.
Cancer Res. 2012.
PMID: 22986742
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Pretubulysin: a new option for the treatment of metastatic cancer.
Braig S, Wiedmann RM, Liebl J, Singer M, Kubisch R, Schreiner L, Abhari BA, Wagner E, Kazmaier U, Fulda S, Vollmar AM.
Braig S, et al. Among authors: wiedmann rm.
Cell Death Dis. 2014 Jan 16;5(1):e1001. doi: 10.1038/cddis.2013.510.
Cell Death Dis. 2014.
PMID: 24434509
Free PMC article.
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Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition.
von Schwarzenberg K, Wiedmann RM, Oak P, Schulz S, Zischka H, Wanner G, Efferth T, Trauner D, Vollmar AM.
von Schwarzenberg K, et al. Among authors: wiedmann rm.
J Biol Chem. 2013 Jan 11;288(2):1385-96. doi: 10.1074/jbc.M112.412007. Epub 2012 Nov 20.
J Biol Chem. 2013.
PMID: 23168408
Free PMC article.
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Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy.
Herrmann J, Elnakady YA, Wiedmann RM, Ullrich A, Rohde M, Kazmaier U, Vollmar AM, Müller R.
Herrmann J, et al. Among authors: wiedmann rm.
PLoS One. 2012;7(5):e37416. doi: 10.1371/journal.pone.0037416. Epub 2012 May 17.
PLoS One. 2012.
PMID: 22616003
Free PMC article.
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Cotargeting stress-activated Hsp27 and autophagy as a combinatorial strategy to amplify endoplasmic reticular stress in prostate cancer.
Kumano M, Furukawa J, Shiota M, Zardan A, Zhang F, Beraldi E, Wiedmann RM, Fazli L, Zoubeidi A, Gleave ME.
Kumano M, et al. Among authors: wiedmann rm.
Mol Cancer Ther. 2012 Aug;11(8):1661-71. doi: 10.1158/1535-7163.MCT-12-0072. Epub 2012 Jun 6.
Mol Cancer Ther. 2012.
PMID: 22675041
Free PMC article.
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Hsp27 promotes insulin-like growth factor-I survival signaling in prostate cancer via p90Rsk-dependent phosphorylation and inactivation of BAD.
Zoubeidi A, Zardan A, Wiedmann RM, Locke J, Beraldi E, Fazli L, Gleave ME.
Zoubeidi A, et al. Among authors: wiedmann rm.
Cancer Res. 2010 Mar 15;70(6):2307-17. doi: 10.1158/0008-5472.CAN-09-3252. Epub 2010 Mar 2.
Cancer Res. 2010.
PMID: 20197463
Free PMC article.
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