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Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast. Identification of point mutations that "silence" a constitutively active mutant M3 receptor and greatly impair receptor/G protein coupling.
Schmidt C, Li B, Bloodworth L, Erlenbach I, Zeng FY, Wess J. Schmidt C, et al. Among authors: wess j. J Biol Chem. 2003 Aug 8;278(32):30248-60. doi: 10.1074/jbc.M304991200. Epub 2003 May 15. J Biol Chem. 2003. PMID: 12750375 Free article.
348 results