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Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.
Uhmann A, Niemann H, Lammering B, Henkel C, Hess I, Nitzki F, Fritsch A, Prüfer N, Rosenberger A, Dullin C, Schraepler A, Reifenberger J, Schweyer S, Pietsch T, Strutz F, Schulz-Schaeffer W, Hahn H. Uhmann A, et al. Mol Cancer Ther. 2011 Nov;10(11):2179-88. doi: 10.1158/1535-7163.MCT-11-0422. Epub 2011 Aug 30. Mol Cancer Ther. 2011. PMID: 21878656
The Hedgehog receptor Patched controls lymphoid lineage commitment.
Uhmann A, Dittmann K, Nitzki F, Dressel R, Koleva M, Frommhold A, Zibat A, Binder C, Adham I, Nitsche M, Heller T, Armstrong V, Schulz-Schaeffer W, Wienands J, Hahn H. Uhmann A, et al. Blood. 2007 Sep 15;110(6):1814-23. doi: 10.1182/blood-2007-02-075648. Epub 2007 May 29. Blood. 2007. PMID: 17536012 Free article.
Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice.
Ecke I, Petry F, Rosenberger A, Tauber S, Mönkemeyer S, Hess I, Dullin C, Kimmina S, Pirngruber J, Johnsen SA, Uhmann A, Nitzki F, Wojnowski L, Schulz-Schaeffer W, Witt O, Hahn H. Ecke I, et al. Cancer Res. 2009 Feb 1;69(3):887-95. doi: 10.1158/0008-5472.CAN-08-0946. Epub 2009 Jan 20. Cancer Res. 2009. PMID: 19155313
Patched knockout mouse models of Basal cell carcinoma.
Nitzki F, Becker M, Frommhold A, Schulz-Schaeffer W, Hahn H. Nitzki F, et al. J Skin Cancer. 2012;2012:907543. doi: 10.1155/2012/907543. Epub 2012 Sep 13. J Skin Cancer. 2012. PMID: 23024864 Free PMC article.
Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.
Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K, Wienands J, Dressel R, Wojnowski L, Binder C, Taguchi T, Beissbarth T, Hogendoorn PC, Antonescu CR, Rubin BP, Schulz-Schaeffer W, Aberger F, van den Brink GR, Hahn H. Pelczar P, et al. Gastroenterology. 2013 Jan;144(1):134-144.e6. doi: 10.1053/j.gastro.2012.09.061. Epub 2012 Oct 3. Gastroenterology. 2013. PMID: 23041331 Free PMC article.
232 results