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Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Kümmerle AE, Schmitt M, Cardozo SV, Lugnier C, Villa P, Lopes AB, Romeiro NC, Justiniano H, Martins MA, Fraga CA, Bourguignon JJ, Barreiro EJ. Kümmerle AE, et al. J Med Chem. 2012 Sep 13;55(17):7525-45. doi: 10.1021/jm300514y. Epub 2012 Aug 30. J Med Chem. 2012. PMID: 22891752
LASSBio-294, A compound with inotropic and lusitropic activity, decreases cardiac remodeling and improves Ca²(+) influx into sarcoplasmic reticulum after myocardial infarction.
Costa DG, da Silva JS, Kümmerle AE, Sudo RT, Landgraf SS, Caruso-Neves C, Fraga CA, de Lacerda Barreiro EJ, Zapata-Sudo G. Costa DG, et al. Among authors: kummerle ae. Am J Hypertens. 2010 Nov;23(11):1220-7. doi: 10.1038/ajh.2010.157. Epub 2010 Jul 29. Am J Hypertens. 2010. PMID: 20671720
The methylation effect in medicinal chemistry.
Barreiro EJ, Kümmerle AE, Fraga CA. Barreiro EJ, et al. Among authors: kummerle ae. Chem Rev. 2011 Sep 14;111(9):5215-46. doi: 10.1021/cr200060g. Epub 2011 Jun 1. Chem Rev. 2011. PMID: 21631125 Review. No abstract available.
38 results