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Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability.
Chetty M, Rose RH, Abduljalil K, Patel N, Lu G, Cain T, Jamei M, Rostami-Hodjegan A. Chetty M, et al. Front Pharmacol. 2014 Nov 26;5:258. doi: 10.3389/fphar.2014.00258. eCollection 2014. Front Pharmacol. 2014. PMID: 25505415 Free PMC article.
Misuse of the well-stirred model of hepatic drug clearance.
Yang J, Jamei M, Yeo KR, Rostami-Hodjegan A, Tucker GT. Yang J, et al. Drug Metab Dispos. 2007 Mar;35(3):501-2. doi: 10.1124/dmd.106.013359. Drug Metab Dispos. 2007. PMID: 17325025 No abstract available.
Prediction of intestinal first-pass drug metabolism.
Yang J, Jamei M, Yeo KR, Tucker GT, Rostami-Hodjegan A. Yang J, et al. Curr Drug Metab. 2007 Oct;8(7):676-84. doi: 10.2174/138920007782109733. Curr Drug Metab. 2007. PMID: 17979655 Review.
The Simcyp population-based ADME simulator.
Jamei M, Marciniak S, Feng K, Barnett A, Tucker G, Rostami-Hodjegan A. Jamei M, et al. Expert Opin Drug Metab Toxicol. 2009 Feb;5(2):211-23. doi: 10.1517/17425250802691074. Expert Opin Drug Metab Toxicol. 2009. PMID: 19199378 Review.
A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recognition of covariates.
Jamei M, Dickinson GL, Rostami-Hodjegan A. Jamei M, et al. Drug Metab Pharmacokinet. 2009;24(1):53-75. doi: 10.2133/dmpk.24.53. Drug Metab Pharmacokinet. 2009. PMID: 19252336 Free article. Review.
Population-based mechanistic prediction of oral drug absorption.
Jamei M, Turner D, Yang J, Neuhoff S, Polak S, Rostami-Hodjegan A, Tucker G. Jamei M, et al. AAPS J. 2009 Jun;11(2):225-37. doi: 10.1208/s12248-009-9099-y. Epub 2009 Apr 21. AAPS J. 2009. PMID: 19381840 Free PMC article. Review.
321 results