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A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk.
Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P, Broomé M, Pragst I, Dickneite G, Wilson MJ, Nash AD, Panousis C, Renné T. Larsson M, et al. Among authors: nolte mw. Sci Transl Med. 2014 Feb 5;6(222):222ra17. doi: 10.1126/scitranslmed.3006804. Sci Transl Med. 2014. PMID: 24500405
Targeting coagulation factor XII as a novel therapeutic option in brain trauma.
Hopp S, Albert-Weissenberger C, Mencl S, Bieber M, Schuhmann MK, Stetter C, Nieswandt B, Schmidt PM, Monoranu CM, Alafuzoff I, Marklund N, Nolte MW, Sirén AL, Kleinschnitz C. Hopp S, et al. Among authors: nolte mw. Ann Neurol. 2016 Jun;79(6):970-82. doi: 10.1002/ana.24655. Epub 2016 Apr 28. Ann Neurol. 2016. PMID: 27043916 Free PMC article.
Tissue distribution of rIX-FP after intravenous application to rodents.
Herrmann S, Doerr B, May F, Kuehnemuth B, Cherpokova D, Herzog E, Dickneite G, Nolte MW. Herrmann S, et al. Among authors: nolte mw. J Thromb Haemost. 2020 Dec;18(12):3194-3202. doi: 10.1111/jth.15069. Epub 2020 Oct 25. J Thromb Haemost. 2020. PMID: 32810892 Free article.
Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation.
Cao H, Biondo M, Lioe H, Busfield S, Rayzman V, Nieswandt B, Bork K, Harrison LC, Auyeung P, Farkas H, Csuka D, Pelzing M, Dower S, Wilson MJ, Nash A, Nolte MW, Panousis C. Cao H, et al. Among authors: nolte mw. J Allergy Clin Immunol. 2018 Oct;142(4):1355-1358. doi: 10.1016/j.jaci.2018.06.014. Epub 2018 Jun 21. J Allergy Clin Immunol. 2018. PMID: 29936101 No abstract available.
42 results