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A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk.
Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P, Broomé M, Pragst I, Dickneite G, Wilson MJ, Nash AD, Panousis C, Renné T. Larsson M, et al. Among authors: panousis c. Sci Transl Med. 2014 Feb 5;6(222):222ra17. doi: 10.1126/scitranslmed.3006804. Sci Transl Med. 2014. PMID: 24500405
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.
Göbel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG. Göbel K, et al. Among authors: panousis c. Nat Commun. 2016 May 18;7:11626. doi: 10.1038/ncomms11626. Nat Commun. 2016. PMID: 27188843 Free PMC article.
Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.
Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P. Wygrecka M, et al. Among authors: panousis c. Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199. doi: 10.1164/rccm.201604-0712OC. Am J Respir Crit Care Med. 2017. PMID: 28005404
Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation.
Cao H, Biondo M, Lioe H, Busfield S, Rayzman V, Nieswandt B, Bork K, Harrison LC, Auyeung P, Farkas H, Csuka D, Pelzing M, Dower S, Wilson MJ, Nash A, Nolte MW, Panousis C. Cao H, et al. Among authors: panousis c. J Allergy Clin Immunol. 2018 Oct;142(4):1355-1358. doi: 10.1016/j.jaci.2018.06.014. Epub 2018 Jun 21. J Allergy Clin Immunol. 2018. PMID: 29936101 No abstract available.
Increased potency of recombinant VWF D'D3 albumin fusion proteins engineered for enhanced affinity for coagulation factor VIII.
Chia J, Pestel S, Glauser I, Emmrich K, Hardy MP, Mischnik M, Raquet E, Tomasetig V, Claar P, Zalewski A, Bass GT, Turnbull V, Chen CG, Wilson MJ, Panousis C, Weimer T, Andrews A, Verhagen AM, Dower SK. Chia J, et al. Among authors: panousis c. J Thromb Haemost. 2021 Nov;19(11):2710-2725. doi: 10.1111/jth.15480. Epub 2021 Aug 17. J Thromb Haemost. 2021. PMID: 34333849 Free article.
Pharmacological Inhibition of Factor XIIa Attenuates Abdominal Aortic Aneurysm, Reduces Atherosclerosis, and Stabilizes Atherosclerotic Plaques.
Searle AK, Chen YC, Wallert M, McFadyen JD, Maluenda AC, Noonan J, Kanellakis P, Zaldivia MTK, Huang A, Lioe H, Biondo M, Nolte MW, Rossato P, Bobik A, Panousis C, Wang X, Hosseini H, Peter K. Searle AK, et al. Among authors: panousis c. Thromb Haemost. 2022 Feb;122(2):196-207. doi: 10.1055/a-1663-8208. Epub 2022 Jan 21. Thromb Haemost. 2022. PMID: 34619795 Free PMC article.
Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III.
Björkqvist J, de Maat S, Lewandrowski U, Di Gennaro A, Oschatz C, Schönig K, Nöthen MM, Drouet C, Braley H, Nolte MW, Sickmann A, Panousis C, Maas C, Renné T. Björkqvist J, et al. Among authors: panousis c. J Clin Invest. 2015 Aug 3;125(8):3132-46. doi: 10.1172/JCI77139. Epub 2015 Jul 20. J Clin Invest. 2015. PMID: 26193639 Free PMC article.
48 results